公开(公告)号：US20190307697A1

公开(公告)日：2019-10-10

申请号：US16335947

申请日：2017-09-21

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Peter X. Ma ,  Ming Dang ,  Laurie K. McCauley

IPC: A61K9/20 ,  A61K38/29 ,  A61K9/70 ,  A61K47/34

Abstract: In an example of a method for making a pulsatile delivery device, one type of charges are generated on a polymeric layer, and charges opposite the one type of charges are generated on a delivery layer including a film forming material and a predetermined substance dispersed throughout the film forming material. The charged polymeric and delivery layers are placed into contact to form a bi-layer structure. A stack with at least two bi-layer structures is formed so that the polymeric layers and the delivery layers are alternating throughout the stack. The stack is sealed so that one of the polymeric layers remains exposed.

公开(公告)号：US20200230159A1

公开(公告)日：2020-07-23

申请号：US16637219

申请日：2018-08-07

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Peter X. Ma ,  Laurie K. McCauley ,  Ming Dang

IPC: A61K31/685 ,  A61K9/16 ,  A61K33/06 ,  A61K47/64 ,  A61K47/54 ,  A61K45/06

Abstract: An apoptosis-mimicking structure includes a polymeric core. The polymeric core includes a polymer backbone. The polymer backbone includes or is modified with a functional group to directly or indirectly bond to an eat me signaling molecule. An eat me signaling molecule is bonded directly or indirectly to the functional group. Other structures include a scaffold and the apoptosis-mimicking structure immobilized on or incorporated into the scaffold.

公开(公告)号：US20230285305A1

公开(公告)日：2023-09-14

申请号：US18199939

申请日：2023-05-20

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Peter X. Ma ,  Ming Dang ,  Laurie K. McCauley

IPC: A61K9/20 ,  A61K9/70 ,  A61K38/29 ,  A61K47/34 ,  A61K9/00

CPC classification number: A61K9/2031 ,  A61K9/204 ,  A61K9/205 ,  A61K9/7007 ,  A61K38/29 ,  A61K47/34 ,  A61K9/0024 ,  A61K9/5031

Abstract: In an example of a method for making a pulsatile delivery device, one type of charges are generated on a polymeric layer, and charges opposite the one type of charges are generated on a delivery layer including a film forming material and a predetermined substance dispersed throughout the film forming material. The charged polymeric and delivery layers are placed into contact to form a bi-layer structure. A stack with at least two bi-layer structures is formed so that the polymeric layers and the delivery layers are alternating throughout the stack. The stack is sealed so that one of the polymeric layers remains exposed.

公开(公告)号：US20230157961A1

公开(公告)日：2023-05-25

申请号：US18099810

申请日：2023-01-20

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Peter X. Ma ,  Ming Dang ,  Laurie K. McCauley

IPC: A61K9/20 ,  A61K9/70 ,  A61K38/29 ,  A61K47/34 ,  A61K9/00

CPC classification number: A61K9/2031 ,  A61K9/204 ,  A61K9/205 ,  A61K9/7007 ,  A61K38/29 ,  A61K47/34 ,  A61K9/0024 ,  A61K9/5031

Abstract: In an example of a method for making a pulsatile delivery device, one type of charges are generated on a polymeric layer, and charges opposite the one type of charges are generated on a delivery layer including a film forming material and a predetermined substance dispersed throughout the film forming material. The charged polymeric and delivery layers are placed into contact to form a bi-layer structure. A stack with at least two bi-layer structures is formed so that the polymeric layers and the delivery layers are alternating throughout the stack. The stack is sealed so that one of the polymeric layers remains exposed.

公开(公告)号：US11571389B2

公开(公告)日：2023-02-07

申请号：US16335947

申请日：2017-09-21

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Peter X. Ma ,  Ming Dang ,  Laurie K. McCauley

IPC: A61K9/20 ,  A61K9/70 ,  A61K38/29 ,  A61K9/00 ,  A61K9/50 ,  A61K47/34

Abstract: In an example of a method for making a pulsatile delivery device, one type of charges are generated on a polymeric layer, and charges opposite the one type of charges are generated on a delivery layer including a film forming material and a predetermined substance dispersed throughout the film forming material. The charged polymeric and delivery layers are placed into contact to form a bi-layer structure. A stack with at least two bi-layer structures is formed so that the polymeric layers and the delivery layers are alternating throughout the stack. The stack is sealed so that one of the polymeric layers remains exposed.