中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

5 records (took 0.013 seconds)

    Polymer/copolymer nanoparticles conjugated to gambogic acid
    1.
    发明授权
    Polymer/copolymer nanoparticles conjugated to gambogic acid 有权

    公开(公告)号：US10786465B2

    公开(公告)日：2020-09-29

    申请号：US15748327

    申请日：2016-07-27

    Applicant: The Texas A&M University System

    Inventor： Naga Venkata Ravi Kumar Majeti ,  Raghu Ganugula ,  Meenakshi Arora ,  Prabhjot Saini

    IPC: A61K9/51 ,  B82Y30/00 ,  A61K47/69 ,  A61K47/54 ,  B82Y5/00

    Abstract: A composition comprising a nanoparticle, wherein the nanoparticle comprises a polymer/copolymer conjugated to a moiety is disclosed. A method of forming a nanostructure includes stirring poly(lactide-co-glycolide (PLGA) and 11-Ethyl-3-(dimethylaminopropyl) carbodiimide (EDC) in CH2Cl2 to create a PLGA mixture, n-boc-ethyelenediamine and N,N-Diisopropylethylamine (DIEA) are added to the PLGA mixture to create a reaction mixture. The reaction mixture is then precipitated in cold diethyl ether to form a purified polymer, which is then dried. The dried and purified polymer is then reconstituted in CH2Cl2:TFA solution and stirred under inert conditions. The product of the reconstituting step is evaporated to form a clear viscous residue that is dissolved in CH2Cl2 and then precipitated in cold ether to form a polymer. These functional polymers can encapsulate a variety of bioactives forming nanosystems improving the performance of bioactives.

    SURFACE ACTIVE NANOSYSTEMS
    3.
    发明申请
    SURFACE ACTIVE NANOSYSTEMS 审中-公开

    公开(公告)号：US20180214386A1

    公开(公告)日：2018-08-02

    申请号：US15748327

    申请日：2016-07-27

    Applicant: The Texas A&M University System

    Inventor： Naga Venkata Ravi Kumar Majeti ,  Prabhjot Saini ,  Raghu Ganugula ,  Meenakshi Arora

    IPC: A61K9/51 ,  A61K47/69 ,  A61K47/54

    CPC classification number: A61K9/5192 ,  A61K9/5153 ,  A61K47/549 ,  A61K47/6937 ,  B82Y5/00 ,  B82Y30/00

    Abstract: A composition comprising a nanoparticle, wherein the nanoparticle comprises a polymer/copolymer conjugated to a moiety is disclosed. A method of forming a nanostructure includes stirring poly(lactide-co-glycolide (PLGA) and 11-Ethyl-3-(dimethylaminopropyl) carbodiimide (EDC) in CH2Cl2 to create a PLGA mixture, n-boc-ethyelenediamine and N,N-Diisopropylethylamine (DIEA) are added to the PLGA mixture to create a reaction mixture. The reaction mixture is then precipitated in cold diethyl ether to form a purified polymer, which is then dried. The dried and purified polymer is then reconstituted in CH2Cl2:TFA solution and stirred under inert conditions. The product of the reconstituting step is evaporated to form a clear viscous residue that is dissolved in CH2Cl2 and then precipitated in cold ether to form a polymer. These functional polymers can encapsulate a variety of bioactives forming nanosystems improving the performance of bioactives.

Patent Agency Ranking