公开(公告)号：US20180326141A1

公开(公告)日：2018-11-15

申请号：US15774800

申请日：2016-11-11

Applicant: TORAY INDUSTRIES, INC.

Inventor： Aishan Han ,  Sari Iwakawa ,  Yoshiyuki Ueno

IPC: A61M1/36 ,  B01D15/12 ,  B01J20/28 ,  B01J20/06

CPC classification number: A61M1/3624 ,  A61M1/36 ,  B01D15/08 ,  B01D15/12 ,  B01J20/02 ,  B01J20/06 ,  B01J20/28 ,  B01J20/28004 ,  B01J20/28057 ,  B01J20/3204 ,  C01F17/00 ,  C01F17/005 ,  C01G23/047 ,  C01G23/0475

Abstract: A phosphorus adsorbent, which is used for adsorbing phosphorus in extracorporeal circulation, is a powder comprising a carbonate of a rare earth metal or an oxide of a Group 4 element and having a solubility in 100 g of water at 20° C. of 10 mg or less. The porous fiber, which comprises the phosphorus adsorbent carried therein, shows a change in pH value of from −1.0 to +1.0 inclusive before and after stirring in physiological saline for 4 hours. The phosphorus adsorption columns respectively comprise the phosphorus adsorbent and the porous fiber each disposed therein.

公开(公告)号：US20240173692A1

公开(公告)日：2024-05-30

申请号：US18283231

申请日：2022-03-17

Applicant: Toray Industries, Inc.

Inventor： Yuka Sakaguchi ,  Akihiro Hayashi ,  Aishan Han ,  Hirokazu Sakaguchi

IPC: B01J20/26 ,  B01J20/28

CPC classification number: B01J20/262 ,  B01J20/28038 ,  B01J20/2808 ,  B01J2220/445

Abstract: A porous adsorption material is used to adsorb and remove an impurity from a solution containing a raw biopharmaceutical compound while suppressing clogging and is high in separation selectivity. The porous adsorption material used to adsorb and remove an impurity from a solution containing a raw biopharmaceutical compound includes a layer containing a nonionic polymer on at least one surface of the porous adsorption material.

公开(公告)号：US20250001399A1

公开(公告)日：2025-01-02

申请号：US18706366

申请日：2022-10-26

Applicant: Toray Industries, Inc.

Inventor： Mariko Yamashita ,  Aishan Han ,  Hirokazu Sakaguchi ,  Yoshiyuki Ueno

IPC: B01J20/289 ,  A61M1/36 ,  B01J20/26 ,  B01J20/28

Abstract: A cell adsorption material includes fibers or particles of a water-insoluble carrier with at least one bound nitrogen-containing compound. The nitrogen-containing compound is selected from polyamines and aliphatic amines. The fibers or particles have a region A within 1.0 μm from an outermost surface of a cross-sectional surface of the fibers or the particles, and a region B within 0.5 μm radius from a center of gravity of the cross-sectional surface of the fibers or the particles, a spectral intensity of 26CN− satisfies formulae (1) and (2) when a spectral intensity of 25C2H− in each of the regions measured by Time of Flight Secondary Ion Mass Spectrometry is set to be 1:0.5≤the spectral intensity of 26CN− in the region A≤3.0 . . . (1); 3.0≤ the spectral intensity of 26CN− in the region A/the spectral intensity of 26CN− in the region B≤20.0 . . . (2).

公开(公告)号：US11135566B2

公开(公告)日：2021-10-05

申请号：US16496633

申请日：2018-03-23

Applicant: Toray Industries, Inc.

Inventor： Aishan Han ,  Hiroaki Fujieda ,  Yoshiyuki Ueno

IPC: A61M1/16 ,  B01D15/18 ,  B01J20/20 ,  B01J20/28 ,  B01J20/285 ,  D01F1/10 ,  D01F6/16 ,  D01F8/10 ,  B01J20/02 ,  B01J20/06 ,  B01J20/26

Abstract: The present invention provides: a porous fiber that exhibits both improved adsorption capacity, and suppressed exposure and detachment of particulates; an adsorption column filled with said porous fiber; and a blood purification system in which an adsorption column is connected to a water removal column. The porous fiber according to the present invention has a three-dimensional pore structure formed by a solid fiber, and satisfies all of the following conditions. (1) The porous fiber has particulates having a diameter of not more than 200 μm, and the percentage of area occupied by said particulates having a diameter of not more than 200 μm in a horizontal cross section of the three-dimensional pore structure is at least 3.0%. (2) The porous fiber does not contain said particulates having a diameter of not more than 200 μm in the region within 1.0 μm in the depth direction from the outermost surface.

公开(公告)号：US20200376465A1

公开(公告)日：2020-12-03

申请号：US16496633

申请日：2018-03-23

Applicant: Toray Industries, Inc.

Inventor： Aishan Han ,  Hiroaki Fujieda ,  Yoshiyuki Ueno

IPC: B01J20/285 ,  A61M1/16 ,  B01J20/26 ,  B01J20/06 ,  B01J20/02 ,  B01J20/20 ,  B01J20/28 ,  B01D15/18 ,  D01F6/16 ,  D01F8/10 ,  D01F1/10

Abstract: The present invention provides: a porous fiber that exhibits both improved adsorption capacity, and suppressed exposure and detachment of particulates; an adsorption column filled with said porous fiber; and a blood purification system in which an adsorption column is connected to a water removal column. The porous fiber according to the present invention has a three-dimensional pore structure formed by a solid fiber, and satisfies all of the following conditions. (1) The porous fiber has particulates having a diameter of not more than 200 μm, and the percentage of area occupied by said particulates having a diameter of not more than 200 μm in a horizontal cross section of the three-dimensional pore structure is at least 3.0%. (2) The porous fiber does not contain said particulates having a diameter of not more than 200 μm in the region within 1.0 μm in the depth direction from the outermost surface.