-
公开(公告)号：US20150198603A1
公开(公告)日：2015-07-16
申请号：US14415520
申请日：2013-07-19
Applicant: TORAY INDUSTRIES, INC.
Inventor： Takayoshi Ido , Fumiyoshi Okano
IPC: G01N33/574
CPC classification number: G01N33/57496 , G01N33/57415 , G01N33/57484 , G01N2800/52
Abstract: This invention provides: a method for detecting a cancer, comprising measuring the expression of a polypeptide having binding reactivity through antigen-antibody reaction with an antibody against CAPRIN-1 having an amino acid sequence shown in any even-numbered SEQ ID NO shown in SEQ ID NOs: 2 to 30 in the Sequence Listing in a biological sample; a method for detecting a cancer which involves determining the presence and the amount of CAPRIN-1 in a sample of a cancer patient in order to determine the administration of a therapeutic drug targeting CAPRIN-1 to the cancer patient; and a drug and a kit for the diagnosis of a cancer, comprising an anti-CAPRIN-1 antibody.
Abstract translation: 本发明提供：一种检测癌症的方法，包括通过抗体 - 抗体反应与具有SEQ ID NO所示SEQ ID NO所示氨基酸序列的抗体的CAPRIN-1的抗体的表达测定 编号NO：生物样品中序列表中的2〜30; 用于检测癌症的方法，其涉及确定癌症患者样品中CAPRIN-1的存在和量的量，以确定靶向CAPRIN-1的治疗药物给予癌症患者; 以及用于诊断癌症的药物和试剂盒，其包含抗CAPRIN-1抗体。
-
公开(公告)号：US11993650B2
公开(公告)日：2024-05-28
申请号：US16800852
申请日：2020-02-25
Applicant: TORAY INDUSTRIES, INC.
Inventor： Fumiyoshi Okano , Takanori Saito , Takayoshi Ido , Masaki Shimizu
IPC: A61K39/00 , C07K16/28 , C07K16/30 , A61K39/395
CPC classification number: C07K16/2803 , C07K16/3015 , C07K16/3061 , A61K39/39558 , A61K2039/505 , C07K2317/732 , C07K2317/734
Abstract: An antibody or a fragment thereof having immunoreactivity to a polypeptide comprising not less than 7 continuous amino acids in the CD179b protein, which was identified as a cancer antigen protein specifically expressed on the surfaces of cancer cells, can be used as a pharmaceutical composition for therapy and/or prophylaxis of cancer.
-
公开(公告)号：US09862774B2
公开(公告)日：2018-01-09
申请号：US14910878
申请日：2014-08-08
Applicant: TORAY INDUSTRIES, INC.
Inventor： Fumiyoshi Okano , Takanori Saito , Yoshitaka Minamida , Takayoshi Ido
CPC classification number: C07K16/30 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K2039/505 , C07K16/28 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3053 , C07K16/3061 , C07K16/3069 , C07K2317/24 , C07K2317/41 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/732
Abstract: It is intended to provide a CAPRIN-1-targeting antibody superior in antitumor activity to conventional antibodies, and use thereof as a therapeutic and/or preventive agent for a cancer. The present invention provides an antibody targeting a CAPRIN-1 polypeptide specifically expressed on the surface of cancer cells, and use of the antibody as a therapeutic and/or preventive agent for a cancer. The present invention provides an antibody which comprises a heavy chain variable region comprising complementarity-determining regions of SEQ ID NOs: 1, 2, and 3 and a light chain variable region comprising complementarity-determining regions of SEQ ID NOs: 4, 5, and 6 and has immunological reactivity with a CAPRIN-1 protein, or a fragment thereof, and a pharmaceutical composition for the treatment and/or prevention of a cancer, comprising this antibody or fragment as an active ingredient.
-
4.发明授权Pharmaceutical composition for treatment of cancer comprising an anti-CAPRIN-1 peptide antibody 有权用于治疗癌症的药物组合物，其包含抗CAPRIN-1肽抗体公开(公告)号：US09573993B2
公开(公告)日：2017-02-21
申请号：US14379872
申请日：2013-02-21
Applicant: TORAY INDUSTRIES, INC.
Inventor： Fumiyoshi Okano , Takanori Saito , Takayoshi Ido , Yoshitaka Minamida
CPC classification number: C07K16/18 , A61K47/6825 , A61K47/6849 , A61K47/6851 , C07K16/28 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/732
Abstract: The invention provides an antibody targeting a cancer antigenic protein specifically expressed on the surface of cancer cells and use thereof in a therapeutic and/or preventive agent for cancer. Specifically, this invention provides an antibody or a fragment thereof which has immunological reactivity with a partial CAPRIN-1 polypeptide consisting of the amino acid sequence shown in SEQ ID NO: 5 or an amino acid sequence having 80% or higher sequence identity to the amino acid sequence, and a pharmaceutical composition for treatment and/or prevention of cancer, comprising the antibody or fragment thereof as an active ingredient.
Abstract translation: 本发明提供靶向癌细胞表面特异性表达的癌抗原蛋白的抗体及其在癌症治疗和/或预防剂中的用途。 具体地，本发明提供了与由SEQ ID NO：5所示的氨基酸序列组成的部分CAPRIN-1多肽或与氨基的序列同一性为80％以上的氨基酸序列具有免疫学反应性的抗体或其片段 酸序列和用于治疗和/或预防癌症的药物组合物，其包含抗体或其片段作为活性成分。
-
5.发明授权Pharmaceutical composition for treatment and/or prevention of gallbladder cancer 有权用于治疗和/或预防胆囊癌的药物组合物公开(公告)号：US09428581B2
公开(公告)日：2016-08-30
申请号：US14389078
申请日：2013-03-29
Applicant: TORAY INDUSTRIES, INC.
Inventor： Takanori Saito , Fumiyoshi Okano , Takayoshi Ido
CPC classification number: C07K16/28 , A61K39/39558 , A61K45/06 , A61K47/6851 , C07K14/47 , C07K16/30 , C07K2317/23 , C07K2317/24 , C07K2317/34 , C07K2317/732
Abstract: Provided is an antibody effective for treatment and/or prevention of gallbladder cancer. A pharmaceutical composition for treatment and/or prevention of gallbladder cancer contains as an active ingredient an antibody or a fragment thereof having immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising at least seven consecutive amino acid residues of the amino acid sequence of the protein.
Abstract translation: 提供一种对于治疗和/或预防胆囊癌有效的抗体。 用于治疗和/或预防胆囊癌的药物组合物含有与CAPRIN-1蛋白或其片段具有免疫学反应性的抗体或其片段作为活性成分，其包含至少七个氨基酸序列的连续氨基酸残基 蛋白质。
-
Patent Agency Ranking
6.发明授权公开(公告)号：US09416193B2
公开(公告)日：2016-08-16
申请号：US14389266
申请日：2013-03-29
Applicant: TORAY INDUSTRIES, INC.
Inventor： Takanori Saito , Fumiyoshi Okano , Takayoshi Ido , Yoshitaka Minamida
CPC classification number: C07K16/303 , A61K39/39558 , A61K45/06 , A61K47/6859 , A61K2039/505 , C07K16/28 , C07K2317/23 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732
Abstract: Provided is an antibody effective for treatment and/or prevention of liver cancer. A pharmaceutical composition for treatment and/or prevention of liver cancer contains as an active ingredient an antibody or a fragment thereof having immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising at least seven consecutive amino acid residues of the amino acid sequence of the protein.
Abstract translation: 提供对于治疗和/或预防肝癌有效的抗体。 用于治疗和/或预防肝癌的药物组合物含有与CAPRIN-1蛋白或其片段具有免疫反应性的抗体或其片段作为活性成分，其包含至少七个氨基酸序列的连续氨基酸残基 蛋白质。
-
7.发明申请PHARMACEUTICAL COMPOSITION FOR TREATMENT AND/OR PREVENTION OF GALLBLADDER CANCER 有权用于治疗和/或预防GALLBLADDER癌症的药物组合物公开(公告)号：US20150299314A1
公开(公告)日：2015-10-22
申请号：US14389078
申请日：2013-03-29
Applicant: TORAY INDUSTRIES, INC.
Inventor： Takanori Saito , Fumiyoshi Okano , Takayoshi Ido
CPC classification number: C07K16/28 , A61K39/39558 , A61K45/06 , A61K47/6851 , C07K14/47 , C07K16/30 , C07K2317/23 , C07K2317/24 , C07K2317/34 , C07K2317/732
Abstract: Provided is an antibody effective for treatment and/or prevention of gallbladder cancer. A pharmaceutical composition for treatment and/or prevention of gallbladder cancer contains as an active ingredient an antibody or a fragment thereof having immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising at least seven consecutive amino acid residues of the amino acid sequence of the protein.
Abstract translation: 提供一种对于治疗和/或预防胆囊癌有效的抗体。 用于治疗和/或预防胆囊癌的药物组合物含有与CAPRIN-1蛋白或其片段具有免疫学反应性的抗体或其片段作为活性成分，其包含至少七个氨基酸序列的连续氨基酸残基 蛋白质。
-
公开(公告)号：US09982059B2
公开(公告)日：2018-05-29
申请号：US15092469
申请日：2016-04-06
Applicant: TORAY INDUSTRIES, INC.
Inventor： Fumiyoshi Okano , Takayoshi Ido , Takanori Saito , Shinichi Kobayashi
IPC: C07K16/30 , A61K39/395 , A61K39/00
CPC classification number: C07K16/3015 , A61K39/39558 , A61K2039/505 , C07K16/30 , C07K16/3053 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/734
Abstract: The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody or fragment thereof having an immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising 7 or more consecutive amino acids.
-
公开(公告)号：US09753038B2
公开(公告)日：2017-09-05
申请号：US14415090
申请日：2013-07-19
Applicant: TORAY INDUSTRIES, INC.
Inventor： Takayoshi Ido , Fumiyoshi Okano
IPC: G01N33/574 , C07K14/47 , C07K16/30 , G01N33/68 , C07K16/18
CPC classification number: G01N33/57496 , C07K14/4738 , C07K14/4748 , C07K16/18 , C07K16/30 , C07K2317/34 , C07K2317/56 , G01N33/57492 , G01N33/6872 , G01N2333/4703
Abstract: This invention provides: a method for detecting a cancer, comprising measuring the expression of a polypeptide having binding reactivity through antigen-antibody reaction with an antibody against CAPRIN-1 having the amino acid sequence shown in any even-numbered SEQ ID NO of SEQ ID NOs: 2 to 30 in the Sequence Listing in a biological sample; a method for detecting a cancer which involves determining the presence and the amount of CAPRIN-1 in a sample of a cancer patient in order to determine the administration of a CAPRIN-1-targeting drug to the cancer patient; and a drug and a kit for the diagnosis of a cancer, comprising an anti-CAPRIN-1 antibody.
-
10.发明申请公开(公告)号：US20150218285A1
公开(公告)日：2015-08-06
申请号：US14389266
申请日：2013-03-29
Applicant: TORAY INDUSTRIES, INC.
Inventor： Takanori Saito , Fumiyoshi Okano , Takayoshi Ido , Yoshitaka Minamida
IPC: C07K16/30 , A61K47/48 , A61K45/06 , A61K39/395
CPC classification number: C07K16/303 , A61K39/39558 , A61K45/06 , A61K47/6859 , A61K2039/505 , C07K16/28 , C07K2317/23 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732
Abstract: Provided is an antibody effective for treatment and/or prevention of liver cancer. A pharmaceutical composition for treatment and/or prevention of liver cancer contains as an active ingredient an antibody or a fragment thereof having immunological reactivity with a CAPRIN-1 protein or a fragment thereof comprising at least seven consecutive amino acid residues of the amino acid sequence of the protein.
Abstract translation: 提供对于治疗和/或预防肝癌有效的抗体。 用于治疗和/或预防肝癌的药物组合物含有与CAPRIN-1蛋白或其片段具有免疫反应性的抗体或其片段作为活性成分，其包含至少七个氨基酸序列的连续氨基酸残基 蛋白质。
-
-
-
-
-
-
-
-
-
Search Results
13
records
(took 0.031 seconds)
