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公开(公告)号：US20250059243A1
公开(公告)日：2025-02-20
申请号：US18756596
申请日：2024-06-27
Applicant: TRUSTEES OF BOSTON UNIVERSITY
Inventor： Ahmad S. KHALIL , Kok Ann GAN , Hanrong YE , Thea Samuelle ORNSTEIN
Abstract: The technology described herein is directed to regulated synthetic gene expression systems. In one aspect described herein are synthetic transcription factors (synTFs) comprising a DNA binding domain, a transcriptional activator domain, a transcriptional effector domain (TED), and optionally a regulator protein. In other aspects described herein are gene expression systems comprising said synTFs and methods of treating diseases and disorders using said synTFs.
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