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公开(公告)号：US20220144939A1
公开(公告)日：2022-05-12
申请号：US17501050
申请日：2021-10-14
Applicant: TRUSTEES OF BOSTON UNIVERSITY
Inventor： Nelson RUIZ-OPAZO , Victoria HERRERA
Abstract: Described herein are methods of treating COVID19 from a coronavirus infection, methods of treating a subject having a coronavirus infection, methods of improving a survival rate of a subject having a coronavirus infection, methods of determining prognosis of a subject having a coronavirus infection, methods of preventing or treating organ-dysfunction or multi-organ dysfunction or failure associated with a coronavirus infection, methods of combinational therapy for a subject having a coronavirus infection, methods of reducing microthrombi formation or low flow organ-ischemia associated with a coronavirus infection by administering a DEspR inhibitor.
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2.发明申请公开(公告)号：US20190381186A1
公开(公告)日：2019-12-19
申请号：US16441208
申请日：2019-06-14
Applicant: Trustees of Boston University
Inventor： Mark W. GRINSTAFF , Christopher GROMISCH , Victoria HERRERA , Nelson RUIZ-OPAZO
Abstract: Described herein are methods and compositions related to the targeting of, e.g., therapeutic agents and uses thereof.
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公开(公告)号：US20210121549A1
公开(公告)日：2021-04-29
申请号：US17080944
申请日：2020-10-27
Applicant: TRUSTEES OF BOSTON UNIVERSITY
Inventor： Nelson RUIZ-OPAZO , Victoria L.M. HERRERA
IPC: A61K39/00 , A61P35/00 , A61K9/51 , C12N9/78 , C12N9/50 , C12N9/08 , C12N9/16 , A61P11/00 , C07K16/28 , A61P9/12
Abstract: Described herein are methods and compositions relating to methods of inhibiting neutrophils, e.g., inhibiting NET release or NETosis, by means of a DEspR inhibitor, e.g., an anti-DEspR antibody reagent. In some embodiments, the methods can relate to the treatment of a disease, e.g., cancer or a disease wherein neutrophils; NETs; or NETosing or NETting neutrophils contribute to pathogenesis, chronicity, or worsening of disease. In some embodiments, the DEspR inhibitor can be a bi-specific reagent or an antibody-drug conjugate.
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