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公开(公告)号：US20180296492A1
公开(公告)日：2018-10-18
申请号：US15986186
申请日：2018-05-22
Applicant: TRUSTEES OF BOSTON UNIVERSITY
Inventor： Bjoern Markus Reinhard , Suryaram Gummuluru
Abstract: Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nanoparticles are endocytosed by the CD169+ expressing cells.
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Patent Agency Ranking
公开(公告)号：US10646451B2
公开(公告)日：2020-05-12
申请号：US15986186
申请日：2018-05-22
Applicant: TRUSTEES OF BOSTON UNIVERSITY
Inventor： Bjoern Markus Reinhard , Suryaram Gummuluru
Abstract: Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nanoparticles are endocytosed by the CD169+ expressing cells.
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公开(公告)号：US11504338B2
公开(公告)日：2022-11-22
申请号：US16844526
申请日：2020-04-09
Applicant: TRUSTEES OF BOSTON UNIVERSITY
Inventor： Bjoern Markus Reinhard , Suryaram Gummuluru
Abstract: Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nanoparticles are endocytosed by the CD169+ expressing cells.
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公开(公告)号：US20210128489A1
公开(公告)日：2021-05-06
申请号：US16844526
申请日：2020-04-09
Applicant: TRUSTEES OF BOSTON UNIVERSITY
Inventor： Bjoern Markus Reinhard , Suryaram Gummuluru
Abstract: Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nanoparticles are endocytosed by the CD169+ expressing cells.
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公开(公告)号：US10004695B2
公开(公告)日：2018-06-26
申请号：US15304127
申请日：2015-04-08
Applicant: TRUSTEES OF BOSTON UNIVERSITY
Inventor： Bjoern Markus Reinhard , Suryaram Gummuluru
CPC classification number: A61K9/5123 , A61B5/055 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/5115 , A61K9/5192 , A61K47/543 , A61K47/61 , A61K47/6911 , A61K47/6923 , A61K47/6929 , B82Y5/00 , G01N33/5005
Abstract: Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nanoparticles are endocytosed by the CD169+ expressing cells.
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公开(公告)号：US20170042824A1
公开(公告)日：2017-02-16
申请号：US15304127
申请日：2015-04-08
Applicant: TRUSTEES OF BOSTON UNIVERSITY
Inventor： Bjoern Markus Reinhard , Suryaram Gummuluru
CPC classification number: A61K9/5123 , A61B5/055 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/5115 , A61K9/5192 , A61K47/543 , A61K47/61 , A61K47/6911 , A61K47/6923 , A61K47/6929 , B82Y5/00 , G01N33/5005
Abstract: Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nano-particles are endocytosed by the CD169+ expressing cells.
Abstract translation: 本文公开的实施方案涉及总体尺寸在60-100nm之间的含神经节苷脂GM3的混合脂质纳米颗粒，其制备和用途。 纳米颗粒选择性靶向CD169 +表达细胞，如树突状细胞和巨噬细胞。 纳米颗粒被表达CD169 +的细胞内吞。
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