公开(公告)号：US20230045112A1

公开(公告)日：2023-02-09

申请号：US17956249

申请日：2022-09-29

Applicant: Texas Tech University System

Inventor： Kalkunte S. Srivenugopal ,  Ameya M. Paranjpe

IPC: A61K33/34 ,  A61K31/194 ,  A61K47/02 ,  A61K9/48 ,  A61K31/404

Abstract: The present disclosure provides a compositions and methods of inhibiting O6-methylguanine DNA methyltransferase in human tumor cells by providing an effective amount of an agent that directly or indirectly inhibits the O6-methylguanine DNA methyltransferase in a pharmaceutically acceptable carrier, wherein the amount is effective to potentiate an anti-tumor activity of one or more alkylating agents, platinum drugs, or antimetabolites, wherein tumor cells are triggered into programmed cell death.

公开(公告)号：US20160346231A1

公开(公告)日：2016-12-01

申请号：US15116757

申请日：2015-02-06

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： Kalkunte S. Srivenugopal ,  Ameya M. Paranjpe

IPC: A61K31/145 ,  A61K45/06 ,  A61K31/621

CPC classification number: A61K31/145 ,  A61K31/60 ,  A61K31/621 ,  A61K33/00 ,  A61K45/06 ,  A61K2300/00

Abstract: The present disclosure provides a compositions and methods of inhibiting 06-methylguanine DNA methyltransferase in human tumor cells by providing an effective amount of a disulfiram composition to inhibit the 06-methylguanine DNA methyltransferase in a pharmaceutically acceptable carrier to inhibit 06-methylguanine DNA methyltransferase.

Abstract translation: 本公开提供了通过提供有效量的双硫仑组合物来抑制药学上可接受的载体中的06-甲基鸟嘌呤DNA甲基转移酶来抑制06-甲基鸟嘌呤DNA甲基转移酶的方法来抑制人肿瘤细胞中的6-甲基鸟嘌呤DNA甲基转移酶的组合物和方法。