公开(公告)号：US20240238428A1

公开(公告)日：2024-07-18

申请号：US18559821

申请日：2022-05-11

Applicant: Texas Tech University System

Inventor： Ted W. Reid ,  Joe Fralick ,  Phat L. Tran ,  Nicholas Bergfeld ,  Olof Sundin

IPC: A61K47/64 ,  A61K33/04 ,  A61K47/54 ,  A61P31/04 ,  A61P31/14 ,  A61P31/18

CPC classification number: A61K47/64 ,  A61K33/04 ,  A61K47/554 ,  A61P31/04 ,  A61P31/14 ,  A61P31/18

Abstract: The present invention includes composition and methods for making and using a selenium-carrier conjugate for in vivo administration comprising: covalently attaching a selenium compound that reacts in vivo with naturally occurring reduced thiols and oxygen to produce superoxide, which can include a Fenton Complex that allows for a generation of hydroxyl radicals, and that wherein the selenium-carrier conjugate is stabilized against enzymatic degradation and clearance from the body and the synthetic targeting carrier binds target.