公开(公告)号：US10472355B2

公开(公告)日：2019-11-12

申请号：US15513882

申请日：2015-09-25

Applicant: Texas Tech University System

Inventor： Ruiwen Zhang ,  Wei Wang

IPC: C07D471/04

Abstract: An SP-141 compound is a novel small molecule that can serve as a molecular-targeted chemotherapeutic agent. In one embodiment, the labeled compound can comprise SP-141, which comprises 6-methoxy-1-(naphthalen-1-yl)-9 H-pyrido[3,4-b]indote. The compound inhibits expression of oncogenes such as the Mouse Double Minute 2 protein. The compound can bind directly to Mouse Double Minute 2 to inhibit cancer growth including breast cancer growth.

公开(公告)号：US20170283413A1

公开(公告)日：2017-10-05

申请号：US15513882

申请日：2015-09-25

Applicant: Texas Tech University System

Inventor： Ruiwen Zhang ,  Wei Wang

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: An SP-141 compound is a novel small molecule that can serve as a molecular-targeted chemotherapeutic agent. In one embodiment, the labeled compound can comprise SP-141, which comprises 6-methoxy-1-(naphthalen-1-yl)-9 H-pyrido[3,4-b]indote. The compound inhibits expression of oncogenes such as the Mouse Double Minute 2 protein. The compound can bind directly to Mouse Double Minute 2 to inhibit cancer growth including breast cancer growth.