公开(公告)号：US20250000966A1

公开(公告)日：2025-01-02

申请号：US18701156

申请日：2022-10-13

Applicant: The Cleveland Clinic Foundation

Inventor： Jae U. Jung ,  Chih-Jen Lai

IPC: A61K39/215 ,  A61K39/00 ,  A61P37/04 ,  C07K14/005

Abstract: The present disclosure provides compositions and polynucleotides for increasing expression of an immunogenic and/or antigenic polypeptide (e.g., in a vaccine). The disclosure further provides methods of using the disclosed compositions, polynucleotides, and vaccines for the treatment of diseases and disorders (e.g., infections). The compositions and polynucleotides include a first nucleic acid encoding a viral regulatory protein and a second nucleic acid encoding an immunogenic polypeptide, wherein the immunogenic polypeptide is codon-optimized to a vims from which the regulatory protein is derived.