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    Mammaglobin antigens
    2.
    发明授权
    Mammaglobin antigens 失效
    乳腺球蛋白抗原

    公开(公告)号：US5922836A

    公开(公告)日：1999-07-13

    申请号：US933149

    申请日：1997-09-18

    Applicant: Mark A. Watson ,  Timothy P. Fleming

    Inventor： Mark A. Watson ,  Timothy P. Fleming

    IPC: C12N15/09 ,  A61K35/26 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61P35/00 ,  C07K14/47 ,  A61K38/04 ,  C07K1/00

    CPC classification number: C07K14/47 ,  C07K14/4721 ,  A61K38/00 ,  A61K39/00

    Abstract: A purified and isolated DNA sequence and the encoded mammary-specific secreted protein, mammaglobin, are disclosed. Also disclosed are methods for detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin. Immunotherapy-based methods for treating a breast cancer patient with a mammaglobin-expressing tumor are also disclosed. The methods involve using mammaglobin antigens to induce a humoral and/or cell-mediated immune response against the tumor.

    Abstract translation: 公开了纯化和分离的DNA序列和编码的乳腺特异性分泌蛋白，乳腺球蛋白。 还公开了基于乳腺癌细胞的乳腺球蛋白的过表达和分泌来检测乳腺癌的方法。 该方法检测和/或定量乳腺球蛋白或编码乳腺球蛋白的mRNA的存在。 还公开了用表达乳腺球蛋白的肿瘤治疗乳腺癌患者的基于免疫疗法的方法。 该方法涉及使用乳腺球蛋白抗原诱导针对肿瘤的体液和/或细胞介导的免疫应答。

    Mode seeding cathode for a relativistic magnetron
    4.
    发明授权
    Mode seeding cathode for a relativistic magnetron 失效
    相对论磁控管的模式种子阴极

    公开(公告)号：US07245082B1

    公开(公告)日：2007-07-17

    申请号：US11146976

    申请日：2005-06-06

    Applicant: Timothy P. Fleming

    Inventor： Timothy P. Fleming

    IPC: H01J25/50 ,  H01J23/05

    CPC classification number: H01J23/05 ,  H01J25/50

    Abstract: A high-power relativistic magnetron wherein the cathode geometry is shaped to form a DC electric field that has a non-negligible azimuthal component causing preferential selection of the pi mode at startup (suppression of mode competition), a significant increase in radiated power output and time integrated efficiency when compared to standard relativistic magnetron cathode designs.

    Abstract translation: 大功率相对论磁控管，其中阴极几何形状被成形为形成具有不可忽略的方位角分量的DC电场，该方位角分量在起动时导致pi模式的优先选择（抑制模式竞争），辐射功率输出的显着增加和 与标准相对论磁控阴极设计相比，时间集成效率。

    Mammaglobin, a secreted mammary-specific breast cancer protein
    5.
    发明授权
    Mammaglobin, a secreted mammary-specific breast cancer protein 有权
    乳腺珠蛋白，一种分泌乳腺特异性乳腺癌蛋白

    公开(公告)号：US06566072B1

    公开(公告)日：2003-05-20

    申请号：US09162622

    申请日：1998-09-29

    Applicant: Mark A. Watson ,  Timothy P. Fleming

    Inventor： Mark A. Watson ,  Timothy P. Fleming

    IPC: G01N3353

    CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4721 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57415 ,  G01N2800/52

    Abstract: A purified and isolated DNA sequence and the encoded mammary-specific secreted protein, mammaglobin, are disclosed. Also disclosed are methods for detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin. Immunotherapy-based methods for treating a breast cancer patient with a mammaglobin-expressing tumor are also disclosed. The methods involve using mammaglobin antigens to induce a humoral and/or cell-mediated immune response against the tumor.

    Abstract translation: 公开了纯化和分离的DNA序列和编码的乳腺特异性分泌蛋白，乳腺球蛋白。 还公开了基于乳腺癌细胞的乳腺球蛋白的过表达和分泌来检测乳腺癌的方法。 该方法检测和/或定量乳腺球蛋白或编码乳腺球蛋白的mRNA的存在。 还公开了用表达乳腺球蛋白的肿瘤治疗乳腺癌患者的基于免疫疗法的方法。 该方法涉及使用乳腺球蛋白抗原诱导针对肿瘤的体液和/或细胞介导的免疫应答。

    Mammaglobin, a secreted mammary-specific breast cancer protein
    6.
    发明授权
    Mammaglobin, a secreted mammary-specific breast cancer protein 有权
    乳腺珠蛋白，一种分泌乳腺特异性乳腺癌蛋白

    公开(公告)号：US06677428B1

    公开(公告)日：2004-01-13

    申请号：US09509015

    申请日：2000-05-30

    Applicant: Mark A. Watson ,  Timothy P. Fleming

    Inventor： Mark A. Watson ,  Timothy P. Fleming

    IPC: A61K3800

    CPC classification number: C07K14/47 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/112 ,  G01N33/57415

    Abstract: A purified and isolated DNA sequence and the encoded mammary-specific secreted protein, mammaglobin, are disclosed. Also disclosed are methods for detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin. Immunotherapy-based methods for treating a breast cancer patient with a mammaglobin-expressing tumor are also disclosed. The methods involve using mammaglobin antigens to induce a humoral and/or cell-mediated immune response against the tumor.

    Abstract translation: 公开了纯化和分离的DNA序列和编码的乳腺特异性分泌蛋白，乳腺球蛋白。 还公开了基于乳腺癌细胞的乳腺球蛋白的过表达和分泌来检测乳腺癌的方法。 该方法检测和/或定量乳腺球蛋白或编码乳腺球蛋白的mRNA的存在。 还公开了用表达乳腺球蛋白的肿瘤治疗乳腺癌患者的基于免疫疗法的方法。 该方法涉及使用乳腺球蛋白抗原诱导针对肿瘤的体液和/或细胞介导的免疫应答。

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