公开(公告)号：US20190314508A1

公开(公告)日：2019-10-17

申请号：US16349708

申请日：2017-11-13

Applicant: Tokyo University of Science Foundation

Inventor： Etsuko MIYAMOTO ,  Masaaki OZAWA

IPC: A61K47/54 ,  A61P35/00 ,  A61K31/167 ,  A61P7/04

Abstract: A p53 degradation inducing molecule which can induce degradation of p53 proteins or p53 composites, and a pharmaceutical composition containing said p53 degradation inducing molecule are provided. This p53 degradation inducing molecule is a conjugate of a p53 affinity molecule which has affinity for p53 proteins or p53 composites, and a proteolysis induction tag which has affinity for protease and which does not inhibit proteolysis of proteins by protease.

公开(公告)号：US20210088504A1

公开(公告)日：2021-03-25

申请号：US17109187

申请日：2020-12-02

Applicant: Tokyo University of Science Foundation

Inventor： Etsuko MIYAMOTO ,  Masaaki OZAWA

IPC: G01N33/50 ,  C07D239/49 ,  C07K5/00 ,  C12Q1/02 ,  A61K38/00 ,  C12N9/00 ,  C07K14/47 ,  C12N9/76 ,  C12P21/06

Abstract: Provided are: a protein degradation inducing tag which is a molecule that has affinity with proteases and does not inhibit degradation of a protein by proteases; a protein degradation inducing molecule that is a conjugate of at least one protein degradation inducing tag and at least one protein binding molecule that binds to a protein; and a usage of those.

公开(公告)号：US20200000927A1

公开(公告)日：2020-01-02

申请号：US16349689

申请日：2017-11-13

Applicant: Tokyo University of Science Foundation

Inventor： Etsuko MIYAMOTO ,  Masaaki OZAWA

IPC: A61K47/54 ,  A61K38/05 ,  A61P35/00

Abstract: A Ras protein degradation inducing molecule that can induce degradation of Ras proteins, and a pharmaceutical composition that contains this Ras protein degradation inducing molecule are provided. The Ras protein degradation inducing molecule is a conjugate of a Ras protein affinity molecule which has affinity to Ras proteins, and a proteolysis-inducing tag which has affinity to protease and does not inhibit proteolysis of proteins by the protease.

公开(公告)号：US20180164289A1

公开(公告)日：2018-06-14

申请号：US15736089

申请日：2016-06-15

Applicant: Tokyo University of Science Foundation

Inventor： Etsuko MIYAMOTO ,  Masaaki OZAWA

IPC: G01N33/50 ,  C07D239/49 ,  C12Q1/02 ,  C07K5/00 ,  C12N9/76 ,  C07K14/47 ,  C12P21/06

CPC classification number: G01N33/5008 ,  A61K38/00 ,  C07D239/49 ,  C07K5/00 ,  C07K14/4703 ,  C07K2319/70 ,  C07K2319/95 ,  C12N9/00 ,  C12N9/6427 ,  C12P21/06 ,  C12Q1/02 ,  G01N2500/02 ,  G01N2500/10

Abstract: Provided are: a protein degradation inducing tag which is a molecule that has affinity with proteases and does not inhibit degradation of a protein by proteases; a protein degradation inducing molecule that is a conjugate of at least one protein degradation inducing tag and at least one protein binding molecule that binds to a protein; and a usage of those.