公开(公告)号：US20250012695A1

公开(公告)日：2025-01-09

申请号：US18761564

申请日：2024-07-02

Applicant: Trustees of Boston University

Inventor： Ji-Xin Cheng ,  Qing Xia

IPC: G01N15/01 ,  G01N15/1434

Abstract: A wide-field microscopy system and method for imaging a sample include directing infrared light onto the sample to selectively heat the sample. Probe light is also directed onto the sample. An objective collects the probe light after it interacts with the sample. The collected probe light is detected at a detector. A relative distance between the objective and sample is adjusted to introduce an optical defocus enhancement to enhance detection of a change in detected probe light that is indicative of infrared absorption by the sample.