公开(公告)号：US20190330323A1

公开(公告)日：2019-10-31

申请号：US16470996

申请日：2017-12-19

Applicant: UCB BIOPHARMA SPRL

Inventor： NEESHA DEDI ,  BREDA TWOMEY ,  MICHAEL JOHN WRIGHT ,  GARETH DAVIES ,  DAVID JAMES MCMILLAN

IPC: C07K16/22 ,  A61P9/12 ,  C07K14/51 ,  G01N33/68

Abstract: This invention relates to crystals of the human Gremlin-1 protein, and the human Gremlin-1 protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-1 (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-1 activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-1, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.

公开(公告)号：US20180201666A1

公开(公告)日：2018-07-19

申请号：US15742087

申请日：2016-07-05

Applicant: UCB BIOPHARMA SPRL

Inventor： DAVID EDWARD ORMONDE KNIGHT ,  TERENCE SEWARD BAKER ,  DAVID JAMES MCMILLAN ,  ROBERT ANTHONY GRIFFIN ,  GEORGES MAIRET-COELLO ,  PATRICK DOWNEY ,  JEAN-PHILIPPE COURADE

IPC: C07K16/18 ,  A61P25/28

CPC classification number: C07K16/18 ,  A61P25/28 ,  C07K14/4711 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/70 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.

公开(公告)号：US20190284267A1

公开(公告)日：2019-09-19

申请号：US16409945

申请日：2019-05-13

Applicant: UCB BIOPHARMA SPRL

Inventor： DAVID EDWARD ORMONDE KNIGHT ,  TERENCE SEWARD BAKER ,  DAVID JAMES MCMILLAN ,  ROBERT ANTHONY GRIFFIN ,  GEORGES MAIRET-COELLO ,  PATRICK DOWNEY ,  JEAN-PHILIPPE COURADE

IPC: C07K16/18 ,  A61P25/28 ,  C07K14/47

Abstract: The present invention relates to Tau-binding antibodies and binding fragments thereof.