公开(公告)号：US20190106406A1

公开(公告)日：2019-04-11

申请号：US16086698

申请日：2017-04-07

Applicant: UCB Biopharma SPRL

Inventor： Ali Ates ,  Eric Jnoff ,  Laurent Provins ,  Anne Valade ,  Adrian Hall

IPC: C07D401/06 ,  C07D471/04

CPC classification number: C07D401/06 ,  C07D217/06 ,  C07D403/06 ,  C07D471/04

Abstract: The present invention relates to tetrahydroisoquinoline derivatives according to formula (I), wherein G represents a fused heterocyclic system selected from the groups represented by formula (G1), (G2), (G3), (G4), (G5), and (G6), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.

公开(公告)号：US10370355B2

公开(公告)日：2019-08-06

申请号：US16086698

申请日：2017-04-07

Applicant: UCB Biopharma SPRL

Inventor： Ali Ates ,  Eric Jnoff ,  Laurent Provins ,  Anne Valade ,  Adrian Hall

IPC: C07D401/06 ,  C07D471/04

Abstract: The present invention relates to tetrahydroisoquinoline derivatives according to formula (I), wherein G represents a fused heterocyclic system selected from the groups represented by formula (G1), (G2), (G3), (G4), (G5), and (G6), which are Positive Allosteric Modulators of D1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which D1 receptors play a role.