公开(公告)号：US20200377578A1

公开(公告)日：2020-12-03

申请号：US16919576

申请日：2020-07-02

Applicant: UCB Biopharma SPRL

Inventor： David Paul Humphreys ,  Daniel John Lightwood ,  Kerry Louise Tyson ,  David Edward Ormonde Knight ,  Karine Jeannine Madeleine Hervé ,  Joanne Elizabeth Compson ,  Matthew Jon Timothy Page ,  Andrew Charles Payne ,  Nicola Louise Fisher ,  Brendon MacKenzie ,  Matthew Cox

IPC: C07K16/12 ,  A61K39/40 ,  A61K45/06 ,  G01N33/569 ,  G01N33/573 ,  G01N33/68

Abstract: This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of individual Mabs and mixtures thereof.