公开(公告)号：US20200283416A1

公开(公告)日：2020-09-10

申请号：US15774332

申请日：2016-11-24

Applicant: UCB Biopharma SPRL

Inventor： Rebecca Louise Charlton ,  Teresa De Haro Garcia ,  Martin Alexander Lowe ,  Malcolm Maccoss ,  Trevor Morgan ,  Richard David Taylor ,  Zhaoning Zhu

IPC: C07D403/10 ,  C07D471/04 ,  C07D417/10

Abstract: A series of 2-imino-6-methyltetrahydropyrimidin-4(1H)-one derivatives, substituted in the 6-position by a phenyl moiety which in turn is meta-substituted by an optionally substituted unsaturated fused bicyclic ring system containing at least one nitrogen atom, being selective inhibitors of plasmepsin V activity, are beneficial as pharmaceutical agents, especially in the treatment of malaria.

公开(公告)号：US11136310B2

公开(公告)日：2021-10-05

申请号：US15774332

申请日：2016-11-24

Applicant: UCB Biopharma SPRL

Inventor： Rebecca Louise Charlton ,  Teresa De Haro Garcia ,  Martin Alexander Lowe ,  Malcolm Maccoss ,  Trevor Morgan ,  Richard David Taylor ,  Zhaoning Zhu

IPC: C07D403/10 ,  C07D417/10 ,  C07D471/04

Abstract: A series of 2-imino-6-methyltetrahydropyrimidin-4(1H)-one derivatives, substituted in the 6-position by a phenyl moiety which in turn is meta-substituted by an optionally substituted unsaturated fused bicyclic ring system containing at least one nitrogen atom, being selective inhibitors of plasmepsin V activity, are beneficial as pharmaceutical agents, especially in the treatment of malaria.