公开(公告)号：US20180195986A1

公开(公告)日：2018-07-12

申请号：US15742700

申请日：2016-07-07

Applicant: UNIVERSAL BIO RESEARCH Co., Ltd.

Inventor： Hideji TAJIMA

IPC: G01N27/02 ,  G01N27/27 ,  G01N27/28 ,  G01N35/10

CPC classification number: G01N27/02 ,  G01N27/27 ,  G01N27/28 ,  G01N35/10

Abstract: A device for electrical measurement of a target chemical substance includes: an electrode array element including a base, an electrode array section in which electrodes which are disposed on the base and to each of which a test substance is fixed or can be fixed are arrayed, and a terminal array section in which terminals disposed on the base so as to correspond to the electrodes and electrically connected to the electrodes are arrayed; a processing head having an electrode array element support section supporting the electrode array element detachably to make electrical connection to the terminals possible; a container group including a liquid storing section and a measurement container; a support section moving mechanism; and a measurement section capable of measuring a signal generated by applying a predetermined voltage to a test substance fixed to each of the electrodes in the measurement container.

公开(公告)号：US20200061609A1

公开(公告)日：2020-02-27

申请号：US16610797

申请日：2018-05-10

Applicant: UNIVERSAL BIO RESEARCH CO., LTD.

Inventor： Hideji TAJIMA

IPC: B01L3/00 ,  B01L7/00

Abstract: A cartridge 100 for nucleic acid detection is provided with: a first member 110 having multiple nucleic acid extraction wells; a second member 120 having a nucleic acid amplification and determination well for amplification of a nucleic acid and detection of the amplified nucleic acid; and multiple reagent containers 130. The multiple reagent containers 130 are fixed between the first member 110 and the second member 120.

公开(公告)号：US20190224666A1

公开(公告)日：2019-07-25

申请号：US16327130

申请日：2017-08-18

Applicant: UNIVERSAL BIO RESEARCH Co., Ltd.

Inventor： Hideji TAJIMA ,  Kazuhiro NAKAMURA ,  Yu SUGIYAMA

IPC: B01L3/02 ,  B01L3/00 ,  G01N1/14 ,  B01J4/02

Abstract: A compact, easily handled, and highly accurate dispensing cylinder capable of performing a dispensing treatment for both minute and large amounts of liquid using a single mechanism, and a dispensing treatment method using the dispensing cylinder. The dispensing cylinder includes: a cylinder having a cavity therein; a nozzle provided at one end of the cylinder, having a through hole communicating with the cavity and extending in an axial direction of the cavity, and making a dispensing tip attachable to an outside thereof; and a plunger provided so as to be slidable in the cavity in the axial direction. The cavity has a large diameter region having a first inner peripheral surface and a small diameter region provided so as to be closer to a nozzle than the large diameter region and having a second inner peripheral surface. The plunger has a thick shaft portion slidable in the large diameter region and a thin shaft portion protruding from a distal end of the thick shaft portion in the axial direction and slidable in the small diameter region.

公开(公告)号：US20160017441A1

公开(公告)日：2016-01-21

申请号：US14761120

申请日：2014-01-16

Applicant: UNIVERSAL BIO RESEARCH CO., LTD.

Inventor： Hideji TAJIMA ,  Harumi GINYA ,  Tomoyuki HATANO ,  Masaaki TAKAHASHI ,  Ryouji KARINAGA

IPC: C12Q1/68 ,  G06F19/20

CPC classification number: C12Q1/6888 ,  C12Q1/6809 ,  C12Q2600/154 ,  G16B25/00 ,  C12Q2523/125 ,  C12Q2537/165 ,  C12Q2539/115 ,  C12Q2565/501

Abstract: It is an object of the present invention to provide a method for analyzing, in detail, the epigenetic state of stem cells.The present invention provides a method for identifying stem cells, which comprises analyzing the patterns of methylation and demethylation of chromosomal DNA extracted from test stem cells, and correlating the analyzed patterns with the properties of the test stem cells.

Abstract translation: 本发明的目的是提供一种详细分析干细胞的表观遗传状态的方法。 本发明提供了一种用于鉴定干细胞的方法，其包括分析从测试干细胞提取的染色体DNA的甲基化和去甲基化模式，并将分析的模式与测试干细胞的性质相关联。

公开(公告)号：US20200033372A1

公开(公告)日：2020-01-30

申请号：US16497843

申请日：2018-03-28

Applicant: UNIVERSAL BIO RESEARCH CO., LTD.

Inventor： Hideji TAJIMA

IPC: G01N35/04 ,  G01N35/00

Abstract: The specimen treatment and measurement system 2000 according to the present invention is provided with: a movement stage 2300 having a plurality of treatment lanes for treating specimens in parallel; a consumables supply module 2100 for storing consumables for use in treatment of the specimens, and supplying the consumables to the movement stage 2300; a cartridge supply module 2500 for storing cartridges for use in treatment of the specimens, and supplying the cartridges to the movement stage 2300; and a stage transfer mechanism 2400 for transferring the movement stage 2400 to each module. The cartridge supply module 2500 has a plurality of cartridge cartons for accommodating the cartridges stacked on top of each other, and a push-out mechanism for pushing cartridges out of a cartridge carton to a supply position of the cartridge supply module 2500.

公开(公告)号：US20190120752A1

公开(公告)日：2019-04-25

申请号：US16091287

申请日：2017-04-07

Applicant: UNIVERSAL BIO RESEARCH Co., Ltd.

Inventor： Hideji TAJIMA

IPC: G01N21/27 ,  G01N21/01 ,  G01N21/64 ,  G01N21/76

Abstract: A general-purpose optical measuring device enables at least measurement of a nucleic acid amplification amount; detection or quantitative measurement by a nucleic acid detection method, an immunoassay method, an enzyme method; or measurement of concentration or absorbance, and a method of the same. There are included a photometric content designation unit, an irradiation reception pair including an emission end that can emit measurement light, and a reception end that can receive light from the emission end, a photometric container that can store measurement target chemical substance solution, and includes a bottom portion having a formed translucent region, a nozzle communicated with a suction discharge mechanism of gas, a flow tube, an optical measurement unit, and a control unit configured to suck and hold the chemical substance solution into the flow tube, or store the chemical substance solution into the photometric container.

公开(公告)号：US20160201023A1

公开(公告)日：2016-07-14

申请号：US14916764

申请日：2014-09-02

Applicant: UNIVERSAL BIO RESEARCH CO., LTD.

Inventor： Hideji TAJIMA

IPC: C12M1/00 ,  C12M3/00 ,  C12N5/071

Abstract: A culture system comprises: a preparatory culture vessel and a main culture vessel that accommodate cells and a solution; a main stage that holds the preparatory culture vessel and the main culture vessel; a connecting tube that connects the culture vessels; a valve that opens and closes the connecting tube; and a rotating mechanism that rotates the main stage and imparts a height difference between the culture vessels to transfer the cells and solution by dropping between the culture vessels.

Abstract translation: 培养系统包括：准备培养容器和容纳细胞和溶液的主培养容器; 是筹备文化船和主培养容器的主要阶段; 连接培养容器的连接管; 打开和关闭连接管的阀; 以及旋转机构，其旋转主级并赋予培养容器之间的高度差以通过在培养容器之间滴落来转移细胞和溶液。

公开(公告)号：US20160025722A1

公开(公告)日：2016-01-28

申请号：US14874154

申请日：2015-10-02

Applicant: UNIVERSAL BIO RESEARCH CO., LTD.

Inventor： Hideji TAJIMA

IPC: G01N33/543 ,  B01L3/00

CPC classification number: G01N33/54386 ,  B01L3/508 ,  B01L3/52 ,  B01L2200/10 ,  B01L2300/0636 ,  C12Q1/6804 ,  G01N33/54326 ,  G01N33/54393 ,  G01N35/026 ,  G01N35/1009 ,  Y10T436/143333 ,  Y10T436/25125 ,  C12Q2563/143

Abstract: This invention relates to an assay device and a method for pretreating a specimen containing a biologically-relevant substance and then assaying the biologically-relevant substance. Biologically-relevant substances used in the assay method include microorganisms, cells, viruses, nucleic acids, polysaccharides, proteins (including antigens, antibodies, chromoproteins, and enzymes), peptides, nucleic acids, and small molecules. This pretreatment method removes contaminants from the biologically-relevant substances using supports such as magnetic particles, gels, resins, membranes, and solid-phased reagents. Therefore, in the assay method the following steps are generally carried out (i) a pretreatment step of treating a specimen using one or more first supports and then one or more second supports, and (ii) the assay step carried out after the pretreatment step. In particular, the pretreatment method reduces false positives and false negatives in the assay.

Abstract translation: 本发明涉及一种用于预处理含有生物相关物质并然后测定生物相关物质的试样的测定装置和方法。 用于测定方法的生物相关物质包括微生物，细胞，病毒，核酸，多糖，蛋白质（包括抗原，抗体，色蛋白和酶），肽，核酸和小分子。 这种预处理方法使用诸如磁性颗粒，凝胶，树脂，膜和固相试剂的载体从生物相关物质中除去污染物。 因此，在测定方法中，通常进行以下步骤：（i）使用一种或多种第一载体然后一种或多种第二载体处理样品的预处理步骤，和（ii）在预处理步骤之后进行的测定步骤 。 特别地，预处理方法减少了测定中的假阳性和假阴性。

公开(公告)号：US20240319052A1

公开(公告)日：2024-09-26

申请号：US18579780

申请日：2022-07-20

Applicant: UNIVERSAL BIO RESEARCH CO., LTD.

Inventor： Hideji TAJIMA

IPC: G01N1/34 ,  B03C1/01 ,  B03C1/28 ,  B03C1/30

CPC classification number: G01N1/34 ,  B03C1/01 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/18

Abstract: An extracting device 200 includes a plurality of extraction vessels 210 which retain a solution containing magnetic particles and a sample, an oscillating mechanism 220 which oscillates the extraction vessels 210, magnet bodies which exert a magnetic force on extraction vessels 210, a magnet moving mechanism 258, 259 which moves the magnet bodies between a contact position in which the magnet bodies are in contact with the extraction vessels 210 and a non-contact position, a temperature adjustment unit which adjusts a temperature of the extraction vessels 210, a temperature adjustment unit moving mechanism 248, 249 which moves the temperature adjustment unit between a contact position in which the temperature adjustment unit is in contact with the extraction vessels 210 and a non-contact position in which the temperature adjustment unit is not in contact with the extraction vessels 210, and a control unit which controls an action of each of the mechanisms.

公开(公告)号：US20240254471A1

公开(公告)日：2024-08-01

申请号：US18561218

申请日：2022-05-27

Applicant: UNIVERSAL BIO RESEARCH CO., LTD.

Inventor： Hideji TAJIMA

IPC: C12N15/10 ,  G01N35/10

CPC classification number: C12N15/1003 ,  G01N35/1081

Abstract: A specimen processing apparatus 1000 comprising: a plurality of container holders 510 holding, in one row, a plurality of second nucleic acid containers housing the nucleic acids; a pitch conversion mechanism 500 converting a pitch of the plurality of container holders between a smaller pitch and a larger pitch; a plurality of treatment lanes extracting the plurality of nucleic acid from a plurality of specimens in parallel; a first nozzle unit 200 including a plurality of first nozzles 210 disposed in one row at the greater pitch and moving over the plurality of treatment lanes; a PCR plate 128 having a plurality of wells disposed in one row at the smaller pitch; a second nozzle unit 300 including a plurality of second nozzles 310 disposed in one row at the smaller pitch and moving between a location above the plurality of container holders having the smaller pitch and a location above the PCR plate 128; and a control unit controlling operation of respective parts.