公开(公告)号：US11780926B2

公开(公告)日：2023-10-10

申请号：US16982714

申请日：2018-03-22

Applicant: UNIVERSITÄT STUTTGART

Inventor： Oliver Seifert ,  Roland Kontermann ,  Fabian Richter

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/32 ,  A61K39/395 ,  A61K38/00 ,  G01N33/50

CPC classification number: C07K16/2863 ,  A61K39/39533 ,  A61P35/00 ,  C07K16/2878 ,  C07K16/32 ,  A61K38/00 ,  C07K2317/30 ,  C07K2317/526 ,  C07K2317/60 ,  C07K2317/62 ,  C07K2317/64 ,  C07K2317/66 ,  C07K2317/73 ,  C07K2317/75 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/5091

Abstract: The present invention relates to a modular multivalent antigen-binding protein complex, use of the antigen-binding protein complex in medicine and use of the antigen-binding protein complex in the prophylaxis, treatment or diagnosis of a disorder or disease.

公开(公告)号：US11851489B2

公开(公告)日：2023-12-26

申请号：US16615536

申请日：2018-06-01

Applicant: UNIVERSITÄT STUTTGART

Inventor： Fabian Richter ,  Oliver Seifert ,  Roland Kontermann

IPC: C07K16/28 ,  C07K16/30 ,  C07K16/32 ,  C07K16/40 ,  A61K38/00

CPC classification number: C07K16/2809 ,  C07K16/2878 ,  C07K16/30 ,  C07K16/32 ,  C07K16/40 ,  A61K38/00 ,  C07K2317/31 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/528 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/94

Abstract: The present invention provides a protein complex comprising heterodimerizing regions HRI and HRII, each comprised of antiparallel β-strands and intervening regions wherein HRI and HRII are each interspersed fusion proteins of two human constant regions of an immunoglobulin or immunoglobulin-like proteins. The present invention also provides nucleic acid molecules comprising a sequence encoding said protein complexes and vectors comprising the nucleic acid. The present invention also provides the protein complex, the nucleic acid and the vector for use as a medicament. The present invention further provides a method of determining the amino acid sequence of HRI and/or of the amino acid sequence of HRII. The present invention also provides a method of producing amino acid chains of HRI and/or amino acid chains of HRII. The present invention further provides the protein complex for use in the N prophylaxis, treatment or diagnosis of a disorder or a disease.

公开(公告)号：US10689452B2

公开(公告)日：2020-06-23

申请号：US16091456

申请日：2017-04-04

Applicant: UNIVERSITÄT STUTTGART ,  BALIOPHARM AG

Inventor： Roland Kontermann ,  Klaus Pfizenmaier ,  Fabian Richter ,  Kirstin Zettlitz ,  Peter Scheurich ,  Andreas Herrmann

IPC: C07K16/28 ,  A61P37/06

Abstract: The invention provides for an inhibitor of the huTNFRI receptor which is a human or humanized antibody construct that monovalently recognizes huTNFRI through an antigen-binding moiety, which is characterized by specific CDR sequences, a pharmaceutical preparation thereof, method of producing the inhibitor and the medical use of the inhibitor.