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公开(公告)号：US09624289B2
公开(公告)日：2017-04-18
申请号：US14539884
申请日：2014-11-12
Applicant: University Health Network
Inventor： Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705 , A61K38/17
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号：US20150139995A1
公开(公告)日：2015-05-21
申请号：US14539879
申请日：2014-11-12
Applicant: University Health Network
Inventor： Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号：US20180016320A1
公开(公告)日：2018-01-18
申请号：US15583788
申请日：2017-05-01
Applicant: University Health Network
Inventor： Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705 , A61K38/17
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号：US09493561B2
公开(公告)日：2016-11-15
申请号：US14322551
申请日：2014-07-02
Applicant: University Health Network
Inventor： Tak W. Mak , Xiuqiu Lai , Michael W. Tusche
CPC classification number: C07K16/2803 , C07K2317/622
Abstract: The present invention provides methods and compositions for modulating Toso activity and treating diseases and disorders in which Toso is implicated. Such methods and compositions include the use of one or more antibodies that bind to a Toso protein or to a ligand of a Toso protein.
Abstract translation: 本发明提供了用于调节Toso活性并治疗涉及Toso的疾病和病症的方法和组合物。 这样的方法和组合物包括使用结合Toso蛋白质或Toso蛋白质配体的一种或多种抗体。
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公开(公告)号：US20150197551A1
公开(公告)日：2015-07-16
申请号：US14539884
申请日：2014-11-12
Applicant: University Health Network
Inventor： Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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Patent Agency Ranking
公开(公告)号：US20150010542A1
公开(公告)日：2015-01-08
申请号：US14322551
申请日：2014-07-02
Applicant: University Health Network
Inventor： Tak W. Mak , Xiuqiu Lai , Michael W. Tusche
IPC: C07K16/28
CPC classification number: C07K16/2803 , C07K2317/622
Abstract: The present invention provides methods and compositions for modulating Toso activity and treating diseases and disorders in which Toso is implicated. Such methods and compositions include the use of one or more antibodies that bind to a Toso protein or to a ligand of a Toso protein.
Abstract translation: 本发明提供了用于调节Toso活性并治疗涉及Toso的疾病和病症的方法和组合物。 这样的方法和组合物包括使用结合Toso蛋白质或Toso蛋白质配体的一种或多种抗体。
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公开(公告)号：US10822388B2
公开(公告)日：2020-11-03
申请号：US15583788
申请日：2017-05-01
Applicant: University Health Network
Inventor： Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705 , A61K38/17
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号：US09670265B2
公开(公告)日：2017-06-06
申请号：US14539879
申请日：2014-11-12
Applicant: University Health Network
Inventor： Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705 , A61K38/17
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号：US09321824B2
公开(公告)日：2016-04-26
申请号：US14539872
申请日：2014-11-12
Applicant: University Health Network
Inventor： Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705 , A61K38/17
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
Abstract translation: 本发明进一步涉及用于调节Toso蛋白活性的方法和组合物。 本发明还包括使用包括可溶性Toso蛋白的组合物治疗与炎症，自身免疫疾病和癌症相关的病症。
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公开(公告)号：US09228006B2
公开(公告)日：2016-01-05
申请号：US13831031
申请日：2013-03-14
Applicant: University Health Network
Inventor： Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705 , A61K38/17
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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