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1.发明申请Parasitic Biological Agents for Treatment and Prevention of Graft Versus Host Disease 有权寄生虫药物用于治疗和预防移植物与宿主病公开(公告)号：US20160045581A1
公开(公告)日：2016-02-18
申请号：US14683778
申请日：2015-04-10
Applicant: University of Iowa Research Foundation
Inventor： Mirac Nedim Ince , David E. Elliott , George J. Weiner
CPC classification number: A61K39/0003 , A61K39/001 , A61K2039/577 , A61K2039/58 , G01N33/505 , G01N33/56972 , G01N33/6863 , G01N33/6866 , G01N2333/525 , G01N2333/57 , G01N2800/245 , G01N2800/52
Abstract: The invention relates to helminthic parasite preparations and their use for treatment or prevention of GVHD in a subject that has undergone a transplant. The invention also related to helminthic parasite preparations and their use for prevention of GVHD in a subject prior to a transplant.
Abstract translation: 本发明涉及蠕虫寄生虫制剂及其在经历移植的受试者中治疗或预防GVHD的用途。 本发明还涉及蠕虫寄生虫制剂及其在移植前在受试者中预防GVHD的用途。
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2.发明申请公开(公告)号：US20200181574A1
公开(公告)日：2020-06-11
申请号：US16606567
申请日：2018-04-18
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Laura M. Rogers , George J. Weiner , Adam J. Dupuy
IPC: C12N5/0783 , A61K35/17 , A61P35/00 , C12N15/90 , C12N15/86
Abstract: Disclosed are compositions, kits, and methods for identifying genes that are involved in T-cell trafficking. In particular, the compositions, kits, and methods may be used to identify genes involved in T-cell trafficking and/or infiltration into tumors such as genes that encode immune checkpoint regulators and/or stimulatory agents. The disclosed compositions, kits, and methods utilize the Sleeping Beauty transposon system in a mouse tumor model to identify genes that are involved in T-cell trafficking and infiltration into tumors. The genes identified in the disclosed methods may provide immunotherapy targets in the tumor microenvironment. The identified genes may be utilized in order to develop therapies that enhance T-cell trafficking and infiltration into tumors and/or T-cell killing of tumors such as in chimeric antigen receptor (CAR) T cell therapies.
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公开(公告)号：US09730988B2
公开(公告)日：2017-08-15
申请号：US14683778
申请日：2015-04-10
Applicant: University of Iowa Research Foundation
Inventor： Mirac Nedim Ince , David E. Elliott , George J. Weiner
IPC: A61K39/00 , G01N33/68 , G01N33/50 , G01N33/569
CPC classification number: A61K39/0003 , A61K39/001 , A61K2039/577 , A61K2039/58 , G01N33/505 , G01N33/56972 , G01N33/6863 , G01N33/6866 , G01N2333/525 , G01N2333/57 , G01N2800/245 , G01N2800/52
Abstract: The invention relates to helminthic parasite preparations and their use for treatment or prevention of GVHD in a subject that has undergone a transplant. The invention also related to helminthic parasite preparations and their use for prevention of GVHD in a subject prior to a transplant.
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公开(公告)号：US12195744B2
公开(公告)日：2025-01-14
申请号：US16606567
申请日：2018-04-18
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Laura M. Rogers , George J. Weiner , Adam J. Dupuy
Abstract: Disclosed are compositions, kits, and methods for identifying genes that are involved in T-cell trafficking. In particular, the compositions, kits, and methods may be used to identify genes involved in T-cell trafficking and/or infiltration into tumors such as genes that encode immune checkpoint regulators and/or stimulatory agents. The disclosed compositions, kits, and methods utilize the Sleeping Beauty® transposon system in a mouse tumor model to identify genes that are involved in T-cell trafficking and infiltration into tumors. The genes identified in the disclosed methods may provide immunotherapy targets in the tumor microenvironment. The identified genes may be utilized in order to develop therapies that enhance T-cell trafficking and infiltration into tumors and/or T-cell killing of tumors such as in chimeric antigen receptor (CAR) T cell therapies.
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