公开(公告)号：US20240082238A1

公开(公告)日：2024-03-14

申请号：US17890757

申请日：2022-08-18

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Aliasger K. Salem ,  Kareem Ebeid ,  Youssef Wahib Naguib Ibrahim ,  Sanjib Saha ,  Emad I. Wafa ,  Suhaila Alhaj-Suliman

IPC: A61K31/495 ,  A61K9/16 ,  A61K31/337 ,  A61P15/00 ,  A61P35/00

CPC classification number: A61K31/495 ,  A61K9/1647 ,  A61K31/337 ,  A61P15/00 ,  A61P35/00

Abstract: The invention provides methods, compositions, and kits that are useful for treating cancer (e.g., endometrial cancer).

公开(公告)号：US20220241214A1

公开(公告)日：2022-08-04

申请号：US17620391

申请日：2020-06-19

Applicant: University of Iowa Research Foundation

Inventor： Aliasger K. Salem ,  Kimberly Leslie ,  Xiangbing Meng ,  Jianling Bi ,  Kareem Ebeid ,  Sudartip Areecheewakul

IPC: A61K9/51 ,  A61K33/243 ,  A61K45/06

Abstract: A nanoparticle comprising one or more quinonemethide triterpenoids or one or more inhibitors of metadherin, and methods of using the nanoparticles, are provided.

公开(公告)号：US20220110882A1

公开(公告)日：2022-04-14

申请号：US17529177

申请日：2021-11-17

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Aliasger K. Salem ,  Kristina Thiel ,  Kimberly Leslie ,  Kareem Ebeid

IPC: A61K9/51 ,  A61K31/337 ,  A61K31/496 ,  A61K47/10 ,  A61K47/22

Abstract: Disclosed are nanoparticle compositions and methods for treating cancer in a subject in need thereof. The nanoparticle compositions and methods may be utilized to treat cancers in a subject that are characterized by susceptibility to synthetic lethality via administering a combination of agents that induce synthetic lethality.