公开(公告)号：US09211347B2

公开(公告)日：2015-12-15

申请号：US14030731

申请日：2013-09-18

Applicant: University of Iowa Research Foundation

Inventor： Aliye Uc ,  Paul B. McCray ,  Beverly L. Davidson ,  Abhay Divekar

IPC: A61K48/00

CPC classification number: A61K48/0075

Abstract: The present invention relates to a safe and effective way to deliver and express therapeutic compositions (e.g., transgenes) to the pancreas and lungs of a mammal.

Abstract translation: 本发明涉及用于递送和表达哺乳动物的胰腺和肺的治疗组合物（例如转基因）的安全有效的方法。

公开(公告)号：US20140081240A1

公开(公告)日：2014-03-20

申请号：US14030731

申请日：2013-09-18

Applicant: University of Iowa Research Foundation

Inventor： Aliye Uc ,  Paul B. McCray ,  Beverly L. Davidson ,  Abhay Divekar

IPC: A61K48/00

CPC classification number: A61K48/0075

Abstract: The present invention relates to a safe and effective way to deliver and express therapeutic compositions (e.g., transgenes) to the pancreas and lungs of a mammal.

Abstract translation: 本发明涉及用于递送和表达哺乳动物的胰腺和肺的治疗组合物（例如转基因）的安全有效的方法。

公开(公告)号：US20180271783A1

公开(公告)日：2018-09-27

申请号：US15977858

申请日：2018-05-11

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Paul B. McCray ,  Patrick L. Sinn

IPC: A61K9/00 ,  A61K48/00

CPC classification number: A61K9/0073 ,  A61K9/0043 ,  A61K48/005 ,  A61K48/0075 ,  A61K48/0083 ,  C07K2319/01 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2810/6009 ,  C12N2810/6018 ,  C12N2810/6081

Abstract: The invention provides methods for administering lentiviral vectors to the respiratory system of a patient to treat a disease.

公开(公告)号：US20160108406A1

公开(公告)日：2016-04-21

申请号：US14878829

申请日：2015-10-08

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Paul B. McCray ,  Shyam Ramachandran

IPC: C12N15/113 ,  A61K31/7088 ,  A61K45/06 ,  A61M15/00

CPC classification number: A61K45/06 ,  A61K31/7088 ,  A61M11/042 ,  A61M15/00 ,  A61M15/06 ,  A61M2202/064 ,  A61M2205/3303 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/3653 ,  A61M2205/50 ,  A61M2205/584 ,  A61M2205/609 ,  A61M2205/8206 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2320/31

Abstract: The present invention relates to methods of reducing ΔF508-CFTR ubiquitination or degradation, or increasing ΔF508-CFTR processing or function in a CF cell comprising contacting the cell with a therapeutic agent that inhibits NEDD8, FBXO2, and/or SYVN1 expression in the cell.

Abstract translation: 本发明涉及在CF细胞中减少和/或降低F508-CFTR泛素化或降解或增加和减少F508-CFTR加工或功能的方法，包括使细胞与抑制NEDD8，FBXO2和/或SYVN1表达的治疗剂接触 在细胞中