公开(公告)号：US12173046B2

公开(公告)日：2024-12-24

申请号：US18619759

申请日：2024-03-28

Applicant: Universitat Stuttgart

Inventor： Roman Fischer ,  Martin Siegemund ,  Klaus Pfizenmaier ,  Roland Kontermann

IPC: C07K14/525 ,  A61K38/19 ,  C07K14/705 ,  C07K19/00 ,  A61K38/00

Abstract: The present invention relates to polypeptide consisting of three TNF homology domains of TNF-ligand family members proteins (THD) that specifically bind to the extracellular part of TNFR2, wherein C-terminal and N-terminal reference points are defined by consensus sequences. The THIDs are linked by short stretches of further C-terminal and/or N-terminal amino acids of the THD or variants thereof as well as by peptide linkers. These peptides have an improved stability. Furthermore the invention relates to polypeptide multimers comprising several of the polypeptides of the present invention.

公开(公告)号：US20220267410A1

公开(公告)日：2022-08-25

申请号：US17617137

申请日：2020-06-24

Applicant: Universitat Stuttgart

Inventor： Roman Fischer ,  Martin Siegemund ,  Klaus Pfizenmaier ,  Roland Kontermann

IPC: C07K14/705

Abstract: The present invention relates to polypeptide consisting of three TNF homology domains of TNF-ligand family members proteins (THD) that specifically bind to the extracellular part of TNFR2, wherein C-terminal and N-terminal reference points are defined by consensus sequences. The THDs are linked by short stretches of further C-terminal and/or N-terminal amino acids of the THD or variants thereof as well as by peptide linkers. These peptides have an improved stability. Furthermore the invention relates to polypeptide multimers comprising several of the polypeptides of the present invention.

公开(公告)号：US10570206B2

公开(公告)日：2020-02-25

申请号：US15797059

申请日：2017-10-30

Applicant: UNIVERSITAT STUTTGART

Inventor： Klaus Pfizenmaier ,  Roland Kontermann ,  Martin Siegemund

IPC: C07K14/525 ,  C07K16/28 ,  C07K16/30 ,  C07K19/00 ,  A61K38/19 ,  A61K39/395 ,  C07K14/705 ,  A61K39/00

Abstract: The present invention relates in general to the field of TNF ligand family members. In more detail the present invention relates to polypeptides comprising at least three components A, each of which comprises the sequence of a TNF homology domain (THD) of a TNF ligand family member, or a functional derivative thereof, and comprising at least one component B consisting of a VL region and a VH region linked directly to each other with a linker sequence L which has a length of

公开(公告)号：US20240228581A1

公开(公告)日：2024-07-11

申请号：US18619759

申请日：2024-03-28

Applicant: Universitat Stuttgart

Inventor： Roman Fischer ,  Martin Siegemund ,  Klaus Pfizenmaier ,  Roland Kontermann

IPC: C07K14/705 ,  A61K38/00

CPC classification number: C07K14/70575 ,  A61K38/00 ,  C07K2319/30 ,  C07K2319/70

Abstract: The present invention relates to polypeptide consisting of three TNF homology domains of TNF-ligand family members proteins (THD) that specifically bind to the extracellular part of TNFR2, wherein C-terminal and N-terminal reference points are defined by consensus sequences. The THDs are linked by short stretches of further C-terminal and/or N-terminal amino acids of the THD or variants thereof as well as by peptide linkers. These peptides have an improved stability. Furthermore the invention relates to polypeptide multimers comprising several of the polypeptides of the present invention.