公开(公告)号：US11911416B2

公开(公告)日：2024-02-27

申请号：US16529186

申请日：2019-08-01

Applicant: University of Iowa Research Foundation

Inventor： Bernd Fritzsch ,  Karen Elliott Thompson ,  Marlan Hansen

IPC: A61K35/12 ,  A61K35/36 ,  C12N5/073 ,  A61N1/05

CPC classification number: A61K35/36 ,  A61K35/12 ,  A61N1/0541 ,  C12N5/0603

Abstract: Described herein is a method for treating or restoring loss of hearing and balance in a subject in need thereof. In certain aspects, the disclosed method is comprised of transplanting a humanized otocyst to a target delivery site in the subject. According to certain aspects, the otocyst is obtained from a humanized non-human mammal embryo. In certain exemplary aspects, the non-human mammal is a pig. In certain embodiments, prior to transplantation, the otocyst is cultured in a species-specific tissue culture buffer.

公开(公告)号：US20200061120A1

公开(公告)日：2020-02-27

申请号：US16529186

申请日：2019-08-01

Applicant: University of Iowa Research Foundation

Inventor： Bernd Fritzsch ,  Karen Elliott Thompson ,  Marlan Hansen

IPC: A61K35/36 ,  A61N1/05 ,  C12N5/073

Abstract: Described herein is a method for treating or restoring loss of hearing and balance in a subject in need thereof. In certain aspects, the disclosed method is comprised of transplanting a humanized otocyst to a target delivery site in the subject. According to certain aspects, the otocyst is obtained from a humanized non-human mammal embryo. In certain exemplary aspects, the non-human mammal is a pig. In certain embodiments, prior to transplantation, the otocyst is cultured in a species-specific tissue culture buffer.