公开(公告)号：US20250019702A1

公开(公告)日：2025-01-16

申请号：US18708790

申请日：2022-11-07

Applicant: University of Rochester

Inventor： Peng YAO ,  Omar HEDAYA

IPC: C12N15/113 ,  A61P9/00

Abstract: The present application provides compositions and methods for treating cardiac hypertrophy. In one embodiment, the composition comprises an antisense oligonucleotide 10-50 nucleotides in length, wherein the antisense oligonucleotide is capable of forming a double-stranded structure with a target region downstream of a start codon of an upstream open reading frame (uORF) resided within an mRNA of GATA4, wherein the target region spans a double-stranded stem of a stem-loop structure downstream of the GATA4 uORF start codon

公开(公告)号：US20250066790A1

公开(公告)日：2025-02-27

申请号：US18708838

申请日：2022-11-07

Applicant: University of Rochester

Inventor： Peng YAO ,  Omar HEDAYA

IPC: C12N15/113

Abstract: The present application provides antisense oligonucleotides capable of modulating translation of a main open reading frame in a mRNA of a target gene. Also provided are method of making and method of use for such oligonucleotides.