公开(公告)号：US12240821B2

公开(公告)日：2025-03-04

申请号：US17274736

申请日：2019-07-12

Applicant: University of Southern California

Inventor： Chao Zhang ,  Feng Ni ,  Arunika Ekanayake ,  Biancha Espinosa

IPC: C07D239/94 ,  A61K31/167 ,  A61K31/517 ,  A61K45/06 ,  A61P35/00 ,  C07C235/56 ,  C07C237/42

Abstract: The invention provides a series of GMPS enzyme inhibitors. The invention includes potent GMPS inhibitors that specifically and covalently bind to GMPS, exhibit broad anti-cancer activity, block the infection efficiency of viruses, and have the potentials to suppress undesired immune responses. These novel inhibitors of GMPS, and their derivatives, have tremendous potentials to be used as therapeutic agents for the treatment of cancers, viral infection and immune disorders.

公开(公告)号：US20180064829A1

公开(公告)日：2018-03-08

申请号：US15563318

申请日：2016-04-02

Applicant: University of Southern California

Inventor： Charles E. McKenna ,  Boris A. Kashemirov ,  Shuting Sun ,  Feng Ni

IPC: A61K49/00 ,  C07F9/58 ,  C07F9/6506 ,  C07F9/6558 ,  C07F9/6561

CPC classification number: A61K49/0052 ,  A61K49/0021 ,  A61K49/0032 ,  A61K49/0043 ,  C07F9/58 ,  C07F9/6506 ,  C07F9/65583 ,  C07F9/6561

Abstract: Fluorescent probes based on N-heterocyclic bisphosphonates or their phosphonocarboxylate analogues are provided. The probes have variable spectroscopic properties, bone mineral binding affinities, and pharmacological activities. Methods for preparing the probes include the use of two complementary linking strategies, one involving an amino group and the other involving a chloride group as a precursor to an amino group. In other versions, bifunctional N-heterocyclic bisphosphonates are provided having an amino group and an azido group as linking moieties. In some versions, the linking chemistry allows attachment of a wide selection of fluorescent dyes in the visible to near-infrared range to any of three clinically important heterocyclic bisphosphonates.