公开(公告)号：US20230128344A1

公开(公告)日：2023-04-27

申请号：US17996313

申请日：2021-05-10

Applicant: University of Southern California

Inventor： Yong ZHANG ,  Zhefu DAI ,  Xiao-Nan ZHANG

IPC: A61K47/68 ,  C07K16/28 ,  C12N9/24

Abstract: Antibody-drug conjugates, compositions thereof, and methods use. The antibody-drug conjugates include a fusion protein comprising an antibody covalently linked to an ADP-ribosyl cyclase protein via a peptide linker moiety at one or more of a C-terminus or N-terminus of a heavy or light chain of the antibody, a NAD or NMN analogue, and a payload such that the NAD or NMN analogue is conjugated to both the payload and the ADP-ribosyl cyclase protein.