公开(公告)号：US11684676B2

公开(公告)日：2023-06-27

申请号：US17996313

申请日：2021-05-10

Applicant: University of Southern California

Inventor： Yong Zhang ,  Zhefu Dai ,  Xiao-Nan Zhang

IPC: A61K47/68 ,  C12N9/24 ,  C07K16/28 ,  A61K39/00

CPC classification number: A61K47/6815 ,  A61K47/6807 ,  A61K47/6851 ,  A61K47/6889 ,  C07K16/2851 ,  C12N9/2497 ,  A61K2039/505 ,  C07K2317/90 ,  C07K2319/00 ,  C12Y302/02006

Abstract: Antibody-drug conjugates, compositions thereof, and methods use. The antibody-drug conjugates include a fusion protein comprising an antibody covalently linked to an ADP-ribosyl cyclase protein via a peptide linker moiety at one or more of a C-terminus or N-terminus of a heavy or light chain of the antibody, a NAD or NMN analogue, and a payload such that the NAD or NMN analogue is conjugated to both the payload and the ADP-ribosyl cyclase protein.

公开(公告)号：US11834470B2

公开(公告)日：2023-12-05

申请号：US17281424

申请日：2019-10-04

Applicant: University of Southern California

Inventor： Yong Zhang ,  Zhefu Dai ,  Xiao-Nan Zhang

IPC: A01N43/04 ,  A61K31/70 ,  C07H19/20 ,  A61K31/7076 ,  C12P19/28

CPC classification number: C07H19/20 ,  A61K31/7076 ,  C12P19/28

Abstract: This disclosure provides a method of synthesis of 4′-thioribose NAD+ and analogues thereof, using an efficient chemoenzymatic approach. Also provided are methods of inhibiting the CD38 enzyme and compounds including 4′-thioribose NAD+ and compounds related thereto.

公开(公告)号：US20220227803A1

公开(公告)日：2022-07-21

申请号：US17281424

申请日：2019-10-04

Applicant: University of Southern California

Inventor： Yong Zhang ,  Zhefu Dai ,  Xiao-Nan Zhang

IPC: C07H19/20 ,  C12P19/28 ,  A61K31/7076

Abstract: This disclosure provides a method of synthesis of 4′-thioribose NAD+ and analogues thereof, using an efficient chemoenzymatic approach. Also provided are methods of inhibiting the CD38 enzyme and compounds including 4′-thioribose NAD+ and compounds related thereto.

公开(公告)号：US20200157138A1

公开(公告)日：2020-05-21

申请号：US16615223

申请日：2018-06-08

Applicant: University of Southern California

Inventor： Yong Zhang ,  Xiao-Nan Zhang

IPC: C07H19/207 ,  G01N33/573

Abstract: Provided herein are nicotinamide adenine dinucleotide analogues, compositions comprising such compounds, and methods of using such analogues and compositions.