公开(公告)号：US20210189432A1

公开(公告)日：2021-06-24

申请号：US16610408

申请日：2018-05-10

Applicant: University of Utah Research Foundation

Inventor： Jason D. Shepherd ,  Cameron Day ,  Elissa Pastuzyn

IPC: C12N15/88 ,  C12N7/00 ,  C12N15/113 ,  C07K14/005

Abstract: Disclosed are recombinant Arc capsids. Disclosed are vectors comprising a nucleic acid sequence capable of encoding an Arc protein. Disclosed are cells comprising vectors comprising a nucleic acid sequence capable of encoding an Arc protein. Disclosed are methods of delivering mRNA to a cell comprising administering an Arc capsid to a cell, wherein the Arc capsid comprises an mRNA of interest. Disclosed are methods of delivering mRNA to a cell comprising administering any one of the disclosed vectors to a cell; and administering a mRNA of interest to the cell; wherein the nucleic acid sequence encodes an Arc protein within the cell and Arc capsids are formed, wherein the Arc capsids encapsulate the mRNA of interest. Disclosed are methods of forming Arc capsids comprising administering a vector comprising a nucleic acid sequence capable of encoding an Arc protein to a solution comprising cells, wherein the nucleic acid sequence encodes an Arc protein within the cells and Arc capsids are formed.