公开(公告)号：US20220257725A1

公开(公告)日：2022-08-18

申请号：US17625514

申请日：2020-07-10

Applicant: University of Utah Research Foundation

Inventor： Esther Nuebel ,  Jared Rutter ,  Yu-Chan Chen ,  Joshua Bonkowsky

IPC: A61K38/46 ,  A61K31/197 ,  A61K31/4015 ,  A61P3/00

Abstract: Disclosed herein are compositions and methods for treating mitochondrial dysfunction. The methods can include compositions capable of increasing or overexpressing ATAD1. The methods include restoring mitochondrial respiration and ATP production. The present disclosure provides a mechanism for peroxin (peroxisomal biogenesis factors) accumulation on mitochondria that affects respiration and ATP generation.