公开(公告)号：US11793450B2

公开(公告)日：2023-10-24

申请号：US18065707

申请日：2022-12-14

Applicant: VANDERBILT UNIVERSITY

Inventor： Emmanuel A. Mannoh ,  Anita Mahadevan-Jansen

IPC: A61B5/00 ,  G01N21/65 ,  G01N21/64 ,  A61B34/20

CPC classification number: A61B5/415 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/418 ,  A61B5/4227 ,  A61B5/742 ,  A61B34/20 ,  G01N21/6456 ,  G01N21/65 ,  A61B2034/2055 ,  A61B2505/05 ,  G01N2021/6439 ,  G01N2201/0221

Abstract: One aspect of the invention relates to a method for intraoperative detection of parathyroid gland viability in a surgery, comprising obtaining speckle contrast images of a parathyroid gland of a patent; and displaying the speckle contrast images of the parathyroid gland in real-time.

公开(公告)号：US20230157622A1

公开(公告)日：2023-05-25

申请号：US18065707

申请日：2022-12-14

Applicant: VANDERBILT UNIVERSITY

Inventor： Emmanuel A. Mannoh ,  Anita Mahadevan-Jansen

IPC: A61B5/00 ,  G01N21/65 ,  G01N21/64 ,  A61B34/20

CPC classification number: A61B5/415 ,  G01N21/65 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/418 ,  A61B5/742 ,  A61B5/0071 ,  G01N21/6456 ,  A61B5/4227 ,  A61B34/20 ,  A61B2505/05 ,  G01N2021/6439 ,  A61B2034/2055 ,  G01N2201/0221

Abstract: One aspect of the invention relates to a method for intraoperative detection of parathyroid gland viability in a surgery, comprising obtaining speckle contrast images of a parathyroid gland of a patent; and displaying the speckle contrast images of the parathyroid gland in real-time.

公开(公告)号：US20230165468A1

公开(公告)日：2023-06-01

申请号：US17801862

申请日：2021-02-25

Applicant: VANDERBILT UNIVERSITY

Inventor： Anita Mahadevan-Jansen ,  Carmen C. Solorzano ,  Giju Thomas ,  Emmanuel A. Mannoh

IPC: A61B5/00

CPC classification number: A61B5/0059 ,  A61B1/06

Abstract: A method for intraoperatively determining a degree of parathyroid perfusion includes identifying parathyroid tissues of a living subject using autofluorescence detection with a fiber optic probe based fluorescence detection system; administering to the living subject a contrast agent with a dose; after a period of time of the administration, detecting fluorescence in an area of the parathyroid tissues with the fiber optic probe based fluorescence detection system, where the fluorescence is emitted from the contrast agent; and obtaining a detection level and/or a detection ratio for the parathyroid tissues from the detected fluorescence so as to determine a degree of parathyroid perfusion of each parathyroid. The method is not only unaffected by ambient light, but also has no need of images of the parathyroid tissues.

公开(公告)号：US20250143628A1

公开(公告)日：2025-05-08

申请号：US19004757

申请日：2024-12-30

Applicant: VANDERBILT UNIVERSITY

Inventor： Emmanuel A. Mannoh ,  Anita Mahadevan-Jansen

IPC: A61B5/00 ,  A61B34/20 ,  G01N21/64 ,  G01N21/65

Abstract: One aspect of the invention relates to an apparatus for assessment of parathyroid gland viability comprising a diffuser configured to diffuse a beam of light onto a tissue surface of a parathyroid gland of a patient to illuminate the tissue surface; and means for obtaining speckle contrast images for the assessment of parathyroid gland viability.

公开(公告)号：US12178595B2

公开(公告)日：2024-12-31

申请号：US18377867

申请日：2023-10-09

Applicant: VANDERBILT UNIVERSITY

Inventor： Emmanuel A. Mannoh ,  Anita Mahadevan-Jansen

IPC: A61B5/00 ,  A61B34/20 ,  G01N21/64 ,  G01N21/65

Abstract: One aspect of the invention relates to a method for intraoperative detection of parathyroid gland viability in a surgery, comprising obtaining speckle contrast images of a parathyroid gland of a patent; and displaying the speckle contrast images of the parathyroid gland in real-time.

公开(公告)号：US20240032854A1

公开(公告)日：2024-02-01

申请号：US18377867

申请日：2023-10-09

Applicant: VANDERBILT UNIVERSITY

Inventor： Emmanuel A. Mannoh ,  Anita Mahadevan-Jansen

IPC: A61B5/00 ,  G01N21/65 ,  G01N21/64 ,  A61B34/20

CPC classification number: A61B5/415 ,  G01N21/65 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/418 ,  A61B5/742 ,  A61B5/0071 ,  G01N21/6456 ,  A61B5/4227 ,  A61B34/20 ,  A61B2505/05 ,  G01N2021/6439 ,  A61B2034/2055 ,  G01N2201/0221

Abstract: One aspect of the invention relates to a method for intraoperative detection of parathyroid gland viability in a surgery, comprising obtaining speckle contrast images of a parathyroid gland of a patent; and displaying the speckle contrast images of the parathyroid gland in real-time.

公开(公告)号：US11589801B2

公开(公告)日：2023-02-28

申请号：US16471049

申请日：2017-12-29

Applicant: Vanderbilt University

Inventor： Emmanuel A. Mannoh ,  Anita Mahadevan-Jansen

IPC: G01B11/24 ,  A61B5/00 ,  G01N21/65 ,  G01N21/64 ,  A61B34/20

Abstract: One aspect of the invention relates to a method for intraoperative assessment of parathyroid gland viability in a surgery. The method includes diffusing a beam of light onto a tissue surface of a parathyroid gland of a patient to illuminate the tissue surface; acquiring images of the illuminated tissue surface, where each of the acquired images includes a speckle pattern; and processing the acquired images to obtain speckle contrast images for the intraoperative assessment of parathyroid gland viability.