公开(公告)号：US09824440B2

公开(公告)日：2017-11-21

申请号：US14085732

申请日：2013-11-20

Applicant: VANDERBILT UNIVERSITY

Inventor： Anita Mahadevan-Jansen ,  The-Quyen Nguyen ,  Xiaohong Bi ,  Zain Gowani ,  Ginger Holt ,  Isaac Pence

IPC: G06T7/00 ,  G01N21/64 ,  G01N21/65 ,  A61B5/00

CPC classification number: G06T7/0012 ,  A61B5/0071 ,  A61B5/0075 ,  A61B2505/05 ,  G01N21/6486 ,  G01N21/65 ,  G01N2201/0846 ,  G06T2207/30096

Abstract: In one aspect, the present invention relates to a system evaluating a surgical margin of tumor tissues of a living subject. In one embodiment, the system includes a light source configured to emit a source light; at least one optical probe; a scanner; a spectrometer; and a controller coupled with the scanner and the spectrometer for operably controlling the scanner and the spectrometer. In operation, a working end of the optical probe is positioned proximate to a surface of a specimen of the tumor tissues. A source channel of the optical probe deliver the source light emitted by the light source from the working end to the surface of the specimen, and a plurality of collection channels collect from the working end diffused/reflected light generated from interaction of the source light with the specimen. The spectrometer receives the collected diffused/reflected light to evaluate a margin status of the specimen.

公开(公告)号：US10325366B2

公开(公告)日：2019-06-18

申请号：US15730996

申请日：2017-10-12

Applicant: VANDERBILT UNIVERSITY

Inventor： Anita Mahadevan-Jansen ,  The-Quyen Nguyen ,  Xiaohong Bi ,  Zain Gowani ,  Ginger Holt ,  Isaac Pence ,  John Nguyen

IPC: G06T7/00 ,  G01N21/64 ,  G01N21/65 ,  A61B5/00

Abstract: A method of evaluating a surgical margin of tumor tissues of a living subject includes acquiring images of a specimen of the tumor tissues; calculating a three-dimensional (3D) morphological surface of the specimen from the acquired images and displaying the 3D morphological surface; obtaining, from the 3D morphological surface, a plurality of specimen locations to cover a surface of the specimen; acquiring optical data at each specimen location; evaluating a margin status of the specimen at each specimen location to either positive or negative based on the acquired optical data; and displaying the margin status of the specimen on the 3D morphological surface of the specimen with morphological orientations.

公开(公告)号：US20180053298A1

公开(公告)日：2018-02-22

申请号：US15730996

申请日：2017-10-12

Applicant: VANDERBILT UNIVERSITY

Inventor： Anita Mahadevan-Jansen ,  The-Quyen Nguyen ,  Xiaohong Bi ,  Zain Gowani ,  Ginger Holt ,  Isaac Pence

IPC: G06T7/00 ,  G01N21/65 ,  A61B5/00 ,  G01N21/64

CPC classification number: G06T7/0012 ,  A61B5/0071 ,  A61B5/0075 ,  A61B2505/05 ,  G01N21/6486 ,  G01N21/65 ,  G01N2201/0846 ,  G06T2207/30096

Abstract: A method of evaluating a surgical margin of tumor tissues of a living subject includes acquiring images of a specimen of the tumor tissues; calculating a three-dimensional (3D) morphological surface of the specimen from the acquired images and displaying the 3D morphological surface; obtaining, from the 3D morphological surface, a plurality of specimen locations to cover a surface of the specimen; acquiring optical data at each specimen location; evaluating a margin status of the specimen at each specimen location to either positive or negative based on the acquired optical data; and displaying the margin status of the specimen on the 3D morphological surface of the specimen with morphological orientations.