公开(公告)号：US20240158407A1

公开(公告)日：2024-05-16

申请号：US18549406

申请日：2022-03-03

Applicant: VERSALIS S.P.A.

Inventor： Nicola VECCHINI ,  Federico MONDINI

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: A method for the preparation of amidines or their derivatives, includes the following step



synthesis of nitrile lactams by reaction between a lactam and an α-β unsaturated nitrile;
synthesis of N-(aminoalkyl) lactams by reducing the nitrile lactams;
and synthesis of amidines by dehydrating the N-(aminoalkyl) lactams.

公开(公告)号：US20240166656A1

公开(公告)日：2024-05-23

申请号：US18549412

申请日：2022-03-03

Applicant: VERSALIS S.P.A.

Inventor： Nicola VECCHINI ,  Federico MONDINI

IPC: C07D487/04 ,  B01J21/04

CPC classification number: C07D487/04 ,  B01J21/04

Abstract: A method for preparing amidines or derivatives thereof includes the step of subjecting N-(amino-alkyl) lactams to dehydration in the presence of a heterogeneous catalyst selected from a Lewis acid or an acid resin. The process includes selecting an acid catalyst from heterogeneous acid catalysts selected from Lewis acids or Lewis acids with Bronsted acid components, or heterogeneous acid catalysts based on acid resins.