公开(公告)号：US10314857B2

公开(公告)日：2019-06-11

申请号：US14790568

申请日：2015-07-02

Applicant: Virginia Commonwealth University

Inventor： Joseph D. Roderique

IPC: A61K31/714 ,  A61K9/00 ,  A61K47/22 ,  A61J1/05 ,  A61J1/20

Abstract: Compositions, methods and kits for treating victims of carbon monoxide and/or cyanide poisoning and/or nitric acid-induced vasoplagia are provided. The compositions comprise reduced forms of Vitamin B12 such as reduced hydroxocobalamin or reduced cobinamide, and typically comprise at least one reducing agent (e.g. ascorbic acid). The compositions are generally produced, stored and delivered under reducing, usually anaerobic, conditions in order to preserve the desired oxidation state when introduced into the blood stream of a recipient.

公开(公告)号：US20160000820A1

公开(公告)日：2016-01-07

申请号：US14790568

申请日：2015-07-02

Applicant: Virginia Commonwealth University

Inventor： Joseph D. Roderique

IPC: A61K31/714 ,  A61M3/00 ,  A61J1/05 ,  A61K9/00

CPC classification number: A61K31/714 ,  A61J1/05 ,  A61J1/2093 ,  A61K9/0019 ,  A61K47/22 ,  A61K2300/00

Abstract: Compositions, methods and kits for treating victims of carbon monoxide and/or cyanide poisoning and/or nitric acid-induced vasoplagia are provided. The compositions comprise reduced forms of Vitamin B12 such as reduced hydroxocobalamin or reduced cobinamide, and typically comprise at least one reducing agent (e.g. ascorbic acid). The compositions are generally produced, stored and delivered under reducing, usually anaerobic, conditions in order to preserve the desired oxidation state when introduced into the blood stream of a recipient.

Abstract translation: 提供了治疗一氧化碳和/或氰化物中毒和/或硝酸诱发的血管扩张的受害者的组合物，方法和试剂盒。 组合物包含减少形式的维生素B12，例如还原的羟钴胺素或还原型共生酰胺，并且通常包含至少一种还原剂（例如抗坏血酸）。 通常在还原性（通常为厌氧）条件下制备，储存和递送组合物，以便在被引入接受者的血液流中时保持所需的氧化状态。