公开(公告)号：US20180153616A1

公开(公告)日：2018-06-07

申请号：US15815158

申请日：2017-11-16

Applicant: Wake Forest University Health Sciences

Inventor： Suzy V. Torti ,  Frank M. Torti ,  Andrew Ryan Burke ,  Ravi Nandan-Singh

IPC: A61B18/18 ,  A61N5/06 ,  A61N5/02

CPC classification number: A61B18/18 ,  A61N5/02 ,  A61N5/062 ,  A61N2005/0659

Abstract: In one aspect, methods of treating cancerous tissue are described herein. In some embodiments, a method of treating cancerous tissue comprises inducing necrotic cell death in cancer stem cells in vivo during hyperthermic treatment of the tissue, wherein inducing necrotic cell death comprises positioning nanoparticles adjacent to the cancer stem cells and irradiating the nanoparticles with electromagnetic radiation resulting in membrane damage to the cancer stem cells.

公开(公告)号：US20130304050A1

公开(公告)日：2013-11-14

申请号：US13838814

申请日：2013-03-15

Applicant: WAKE FOREST UNIVERSITY HEALTH SCIENCES

Inventor： Suzy V. Torti ,  Frank M. Torti ,  Andrew Ryan Burke ,  Ravi Nandan-Singh

IPC: A61B18/18

CPC classification number: A61B18/18 ,  A61N5/02 ,  A61N5/062 ,  A61N2005/0659

Abstract: In one aspect, methods of treating cancerous tissue are described herein. In some embodiments, a method of treating cancerous tissue comprises inducing necrotic cell death in cancer stem cells in vivo during hyperthermic treatment of the tissue, wherein inducing necrotic cell death comprises positioning nanoparticles adjacent to the cancer stem cells and irradiating the nanoparticles with electromagnetic radiation resulting in membrane damage to the cancer stem cells.

Abstract translation: 在一个方面，本文描述了治疗癌组织的方法。 在一些实施方案中，治疗癌组织的方法包括在组织的高热处理期间在体内诱导癌干细胞中的坏死细胞死亡，其中诱导坏死性细胞死亡包括将纳米颗粒定位在癌干细胞附近并用电磁辐射照射纳米颗粒， 在膜损伤癌症干细胞。