公开(公告)号：US20170247785A1

公开(公告)日：2017-08-31

申请号：US15517232

申请日：2015-10-13

Applicant: WASHINGTON STATE UNIVERSITY

Inventor： Amit BANDYOPADHYAY ,  Himanshu SAHASRABUDHE ,  Susmita BOSE

IPC: C23C8/24 ,  B33Y40/00 ,  B33Y10/00 ,  B23K26/342 ,  B23K26/70

CPC classification number: C23C8/24 ,  B05C11/00 ,  B22F3/105 ,  B23K26/342 ,  B23K26/70 ,  B23K2103/14 ,  B23K2103/172 ,  B23K2103/52 ,  B33Y10/00 ,  B33Y40/00 ,  C23C24/103 ,  C23C24/106

Abstract: Techniques for reactive deposition are disclosed herein. In one embodiment, a method includes providing laser energy into a deposition environment, the laser energy having a focal point and introducing a first precursor material and a second precursor material into the deposition environment at or near the focal point of the provided laser energy, thereby causing the first and second precursor materials to melt and react to form a composite material different than both the first and second precursor materials. The method also includes allowing the formed composite to solidify by moving the focal point of the provided laser energy away from the melted first and second precursor materials.

公开(公告)号：US20170043055A1

公开(公告)日：2017-02-16

申请号：US15236403

申请日：2016-08-13

Applicant: Washington State University

Inventor： Amit BANDYOPADHYAY ,  Susmita BOSE

IPC: A61L27/30 ,  A61L27/54 ,  A61L27/04

CPC classification number: A61L27/306 ,  A61L27/04 ,  A61L27/047 ,  A61L27/50 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/08 ,  A61L2430/02

Abstract: Various embodiments of surface-modified devices, components, and associated methods of manufacturing are described herein. In one embodiment, an implantable device suitable for being implanted in a patient includes an implantable material having a utile shape and a surface and a modification material deposited on at least a portion of the surface of the implantable material. The modification material has a release rate in an implantation environment in the patient. The modification material at the release rate is effective as bactericidal without being cytotoxic to the patient

Abstract translation: 本文描述了表面改性的器件，部件和相关的制造方法的各种实施例。 在一个实施例中，适于植入患者的可植入装置包括具有钝化形状和表面的可植入材料和沉积在可植入材料表面的至少一部分上的修饰材料。 修饰材料在患者的植入环境中具有释放速率。 在释放速率下的改性材料是有效的杀菌剂，而不会对患者造成细胞毒性

公开(公告)号：US20150352248A1

公开(公告)日：2015-12-10

申请号：US14682343

申请日：2015-04-09

Applicant: WASHINGTON STATE UNIVERSITY

Inventor： Susmita BOSE ,  Amit BANDYOPADHYAY

IPC: A61L27/12 ,  A61L27/58 ,  A61L27/30 ,  A61L27/54 ,  A61L27/32 ,  A61L27/10 ,  A61L27/56

CPC classification number: A61L27/58 ,  A61L27/10 ,  A61L27/12 ,  A61L27/306 ,  A61L27/32 ,  A61L27/425 ,  A61L27/54 ,  A61L27/56 ,  A61L2400/12 ,  A61L2420/06 ,  A61L2430/02 ,  A61L2430/12 ,  C04B35/447 ,  C04B35/6261 ,  C04B2235/3201 ,  C04B2235/3206 ,  C04B2235/3208 ,  C04B2235/3212 ,  C04B2235/3213 ,  C04B2235/3232 ,  C04B2235/3272 ,  C04B2235/3281 ,  C04B2235/3284 ,  C04B2235/3291 ,  C04B2235/34 ,  C04B2235/3418 ,  C04B2235/442 ,  C04B2235/445 ,  C04B2235/5445 ,  C04B2235/608 ,  C04B2235/77 ,  C04B2235/786 ,  C04B2235/80 ,  C04B2235/96

Abstract: Particular aspects of the present disclosure provide bio-resorbable and biocompatible compositions for bioengineering, restoring, or regenerating tissue or bone. In one embodiment, a biocompatible composition includes a three-dimensional porous or non-porous scaffold material comprising a calcium phosphate-based ceramic having at least one dopant therein selected from metal ion dopants or metal oxide dopants. The composition is sufficiently biocompatible to provide for a cell or tissue scaffold, and resorbable at a controlled resorption rate for controlled strength loss under body, body fluid or simulated body fluid conditions.

Abstract translation: 本公开的特定方面提供用于生物工程，恢复或再生组织或骨的生物可再吸收和生物相容性组合物。 在一个实施方案中，生物相容性组合物包括三维多孔或非多孔支架材料，其包含选自金属离子掺杂剂或金属氧化物掺杂剂中的至少一种掺杂剂的磷酸钙基陶瓷。 该组合物具有足够的生物相容性以提供细胞或组织支架，并且以可控吸收速率可再吸收，以在身体，体液或模拟体液条件下控制强度损失。