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    Oligonucleotides, compositions and methods thereof
    1.
    发明授权
    Oligonucleotides, compositions and methods thereof 有权

    公开(公告)号：US11013757B2

    公开(公告)日：2021-05-25

    申请号：US16305937

    申请日：2017-06-02

    Applicant: WAVE LIFE SCIENCES LTD.

    Inventor： Jason Jingxin Zhang ,  Naoki Iwamoto ,  Christopher J. Francis ,  Chandra Vargeese ,  David Charles Donnell Butler ,  Sethumadhavan Divakaramenon ,  Genliang Lu ,  Subramanian Marappan

    IPC: A61K31/7125 ,  C12N15/117 ,  A61K31/7088 ,  A61P21/00

    Abstract: The present disclosure pertains to the recognition that immune responses mediated by CpG oligonucleotides can be affected by the stereochemistry of modified internucleotidic linkages such as phosphorothioates. In some embodiments, the present disclosure relates to chirally controlled CpG oligonucleotide compositions comprising CpG oligonucleotides comprising multiple modified internucleotidic linkages such as phosphorothioate linkages, wherein the oligonucleotides comprise one or more CpG region motifs having defined stereochemistry patterns of chiral internucleotidic linkages. In some embodiments, CpG oligonucleotides comprising one or more CpG region motifs are capable of agonizing an immune response. In some embodiments, CpG oligonucleotides comprising one or more CpG region motifs are antagonistic. Methods for making and using chirally controlled CpG oligonucleotide compositions are also described. In some embodiments, no immune modulation is desired, and the present disclosure provides methods of identifying chirally controlled oligonucleotide compositions which have decreased immune modulation.

    Oligonucleotide compositions and methods thereof
    2.
    发明授权
    Oligonucleotide compositions and methods thereof 有权

    公开(公告)号：US10479995B2

    公开(公告)日：2019-11-19

    申请号：US15746220

    申请日：2016-07-22

    Applicant: WAVE LIFE SCIENCES LTD.

    Inventor： Chandra Vargeese ,  Meena ,  Nenad Svrzikapa ,  Susovan Mohapatra ,  Christopher J. Francis ,  Gregory L. Verdine ,  Anna Sokolovska

    IPC: C12N15/113 ,  C12N15/115 ,  A61P25/28

    Abstract: Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer. In some embodiments, a chirally controlled oligonucleotide composition has any sequence of bases, and/or pattern or base modifications, sugar modifications, backbone modifications and/or stereochemistry, or combination of these elements, described herein.

    OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
    3.
    发明申请
    OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF 有权

    公开(公告)号：US20220162598A1

    公开(公告)日：2022-05-26

    申请号：US16869126

    申请日：2020-05-07

    Applicant: WAVE LIFE SCIENCES LTD.

    Inventor： Chandra Vargeese ,  Meena ,  Nenad Svrzikapa ,  Susovan Mohapatra ,  Christopher J. Francis ,  Gregory L. Verdine ,  Anna Sokolovska

    IPC: C12N15/11 ,  C12N15/113

    Abstract: Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer. In some embodiments, a chirally controlled oligonucleotide composition has any sequence of bases, and/or pattern or base modifications, sugar modifications, backbone modifications and/or stereochemistry, or combination of these elements, described herein.

    OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
    6.
    发明申请
    OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF 有权

    公开(公告)号：US20220195429A1

    公开(公告)日：2022-06-23

    申请号：US17375658

    申请日：2021-07-14

    Applicant: WAVE LIFE SCIENCES LTD.

    Inventor： Chandra Vargeese ,  Meena ,  Nenad Svrzikapa ,  Susovan Mohapatra ,  Christopher J. Francis ,  Gregory L. Verdine ,  Anna Sokolovska

    IPC: C12N15/113 ,  C12N15/115 ,  A61P25/28

    Abstract: Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer. In some embodiments, a chirally controlled oligonucleotide composition has any sequence of bases, and/or pattern or base modifications, sugar modifications, backbone modifications and/or stereochemistry, or combination of these elements, described herein.

    OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
    7.
    发明申请
    OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF 审中-公开

    公开(公告)号：US20200080083A1

    公开(公告)日：2020-03-12

    申请号：US16551503

    申请日：2019-08-26

    Applicant: WAVE LIFE SCIENCES LTD.

    Inventor： Chandra Vargeese ,  Meena . ,  Nenad Svrzikapa ,  Susovan Mohapatra ,  Christopher J. Francis ,  Gregory L. Verdine ,  Anna Sokolovska

    IPC: C12N15/113 ,  A61P25/28 ,  C12N15/115

    Abstract: Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same. In some embodiments, a provided chirally controlled oligonucleotide composition provides different cleavage patterns of a nucleic acid polymer than a reference oligonucleotide composition. In some embodiments, a provided chirally controlled oligonucleotide composition provides single site cleavage within a complementary sequence of a nucleic acid polymer. In some embodiments, a chirally controlled oligonucleotide composition has any sequence of bases, and/or pattern or base modifications, sugar modifications, backbone modifications and/or stereochemistry, or combination of these elements, described herein.

    OLIGONUCLEOTIDES, COMPOSITIONS AND METHODS THEREOF
    9.
    发明申请
    OLIGONUCLEOTIDES, COMPOSITIONS AND METHODS THEREOF 有权

    公开(公告)号：US20220401467A1

    公开(公告)日：2022-12-22

    申请号：US17177111

    申请日：2021-02-16

    Applicant: WAVE LIFE SCIENCES LTD.

    Inventor： Jason Jingxin Zhang ,  Naoki Iwamoto ,  Christopher J. Francis ,  Chandra Vargeese ,  David Charles Donnell Butler ,  Sethumadhavan Divakaramenon ,  Genliang Lu ,  Subramanian Marappan

    IPC: A61K31/7125 ,  A61P21/00 ,  C12N15/117 ,  A61K31/7088

    Abstract: The present disclosure pertains to the recognition that immune responses mediated by CpG oligonucleotides can be affected by the stereochemistry of modified internucleotidic linkages such as phosphorothioates. In some embodiments, the present disclosure relates to chirally controlled CpG oligonucleotide compositions comprising CpG oligonucleotides comprising multiple modified internucleotidic linkages such as phosphorothioate linkages, wherein the oligonucleotides comprise one or more CpG region motifs having defined stereochemistry patterns of chiral internucleotidic linkages. In some embodiments, CpG oligonucleotides comprising one or more CpG region motifs are capable of agonizing an immune response. In some embodiments, CpG oligonucleotides comprising one or more CpG region motifs are antagonistic. Methods for making and using chirally controlled CpG oligonucleotide compositions are also described. In some embodiments, no immune modulation is desired, and the present disclosure provides methods of identifying chirally controlled oligonucleotide compositions which have decreased immune modulation.

    OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF
    10.
    发明申请
    OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF 审中-公开

    公开(公告)号：US20200299692A1

    公开(公告)日：2020-09-24

    申请号：US16782021

    申请日：2020-02-04

    Applicant: WAVE LIFE SCIENCES LTD.

    Inventor： Maria David Frank-Kamenetsky ,  Hailin Yang ,  Aaron Jay Morris ,  Chandra Vargeese ,  Christopher J. Francis

    IPC: C12N15/113 ,  C12N15/115 ,  A61P25/28

    Abstract: Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.

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