公开(公告)号：US20160186235A1

公开(公告)日：2016-06-30

申请号：US14853480

申请日：2015-09-14

Applicant: Wafergen, Inc.

Inventor： Victor Joseph ,  Amjad Huda ,  Alnoor Shivji

IPC: C12Q1/68 ,  B01L7/00

CPC classification number: C12Q1/686 ,  B01L7/525 ,  B01L7/5255 ,  B01L7/54 ,  B01L2200/10 ,  B01L2200/147 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/0893 ,  B01L2300/1805 ,  B01L2300/1827 ,  B01L2300/1844 ,  B01L2300/1894 ,  G01N21/0332 ,  G01N21/253

Abstract: Apparatus, systems, chips, and methods of performing a large number of simultaneous chemical reactions are provided herein. The chips of the invention comprise addressable units that can be addressed according to the temperature of the reaction to be run. The subject apparatus, systems, and chips are particularly suited for performing polymerase chain reactions on thousands of nucleic acid sequences, up to and including sequences of an entire genome of an organism of interest.

公开(公告)号：US20160237477A1

公开(公告)日：2016-08-18

申请号：US15138869

申请日：2016-04-26

Applicant: WaferGen, Inc.

Inventor： Victor Joseph ,  Amjad Huda ,  Alnoor Shivji ,  Jie Zhou

IPC: C12Q1/68 ,  H01L27/144 ,  H01L31/024 ,  B01L3/00 ,  H01L31/0203 ,  H01L31/18 ,  G01N21/01 ,  B01L7/00 ,  H01L31/105 ,  H01L31/0232

CPC classification number: C12Q1/686 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/0689 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1827 ,  B82Y30/00 ,  C12Q1/6806 ,  C12Q1/6844 ,  G01N21/01 ,  G01N21/0332 ,  G01N21/6408 ,  G01N21/6452 ,  G01N21/76 ,  G01N35/0099 ,  G01N2021/6417 ,  G01N2021/6484 ,  G01N2035/0405 ,  G01N2201/0231 ,  H01L27/1443 ,  H01L31/0203 ,  H01L31/02325 ,  H01L31/024 ,  H01L31/105 ,  H01L31/18 ,  C12Q2565/501

Abstract: The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost amplification of nucleic acids.

公开(公告)号：US20160138082A1

公开(公告)日：2016-05-19

申请号：US14857379

申请日：2015-09-17

Applicant: WaferGen, Inc.

Inventor： Victor Joseph ,  Amjad Huda ,  Alnoor Shivji ,  Jie Zhou

IPC: C12Q1/68 ,  B01L7/00 ,  B01L3/00

CPC classification number: C12Q1/686 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/0689 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/1827 ,  B82Y30/00 ,  C12Q1/6806 ,  C12Q1/6844 ,  G01N21/01 ,  G01N21/0332 ,  G01N21/6408 ,  G01N21/6452 ,  G01N21/76 ,  G01N35/0099 ,  G01N2021/6417 ,  G01N2021/6484 ,  G01N2035/0405 ,  G01N2201/0231 ,  H01L27/1443 ,  H01L31/0203 ,  H01L31/02325 ,  H01L31/024 ,  H01L31/105 ,  H01L31/18 ,  C12Q2565/501

Abstract: The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost amplification of nucleic acids.