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Patent Agency Ranking
1.发明申请CELL-NANOFIBER COMPOSITE AND CELL-NANOFIBER-HYDROGEL COMPOSITE AMALGAM BASED ENGINEERED INTERVERTEBRAL DISC 审中-公开细胞 - 纳米纤维复合材料和细胞纳米纤维复合材料基于AMALGAM的工程化椎间盘公开(公告)号：US20100179659A1
公开(公告)日：2010-07-15
申请号：US12443393
申请日：2007-09-27
Applicant: Wan-Ju Li , Leon J. Nesti , Rocky S. Tuan
Inventor： Wan-Ju Li , Leon J. Nesti , Rocky S. Tuan
CPC classification number: A61F2/442 , A61F2/441 , A61F2002/30062 , A61F2002/444 , A61F2002/4445 , A61F2002/445 , A61F2002/4495 , A61F2210/0004 , A61L27/18 , A61L27/3852 , A61L27/3856 , A61L27/52 , A61L27/56 , A61L27/58 , A61L2430/38 , C12N5/0068 , C12N2533/30 , C08L67/04
Abstract: The instant invention is directed to a tissue engineered intervertebral disc comprising at least one inner layer and an exterior layer, wherein: the exterior layer comprises a nanofibrous polymer support comprising one or more polymer nanofibers; the at least one inner layer comprises a hydrogel composition comprising at least one or more hydrogel materials and/or one or more polymer nanofibers; and a plurality of cells which are dispersed throughout the tissue engineered intervertebral disc. Additionally, the instant invention is directed to methods of making such intervertebral discs and methods of treating intervertebral disc damage.
Abstract translation: 本发明涉及包括至少一个内层和外层的组织工程椎间盘，其中：所述外层包含纳米纤维聚合物载体，其包含一种或多种聚合物纳米纤维; 所述至少一个内层包含含有至少一种或多种水凝胶材料和/或一种或多种聚合物纳米纤维的水凝胶组合物; 以及分散在整个组织工程化椎间盘中的多个细胞。 另外，本发明涉及制造这种椎间盘的方法和治疗椎间盘损伤的方法。
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2.发明申请TISSUE ENGINEERED CARTILAGE, METHOD OF MAKING SAME, THERAPEUTIC AND COSMETIC SURGICAL APPLICATIONS USING SAME 审中-公开组织工程化纤维，其制备方法，使用相同的治疗方法和化妆品外科应用公开(公告)号：US20120225039A1
公开(公告)日：2012-09-06
申请号：US13472173
申请日：2012-05-15
Applicant: Wan-Ju Li , Rocky S. Tuan
Inventor： Wan-Ju Li , Rocky S. Tuan
CPC classification number: A61Q90/00 , A61L27/18 , A61L27/3817 , A61L27/3852 , A61L27/3895 , A61L27/56 , A61L2400/12 , A61L2430/06 , C08L67/04
Abstract: Cartilage has been constructed using biodegradable electrospun polymeric scaffolds seeded with chondrocytes or adult mesenchymal stem cells. More particularly engineered cartilage has been prepared where the cartilage has a biodegradable and biocompatible nanofibrous polymer support prepared by electrospinning and a plurality of chondocytes or mesenchymal stem cells dispersed in the pores of the support. The tissue engineered cartilages of the invention possess compressive strength properties similar to natural cartilage. Methods of preparing engineered tissues, including tissue engineered cartilages, are provided in which an electrospun nanofibrous polymer support is provided, the support is treated with a cell solution and the polymer-cell mixture cultured in a rotating bioreactor to generate the cartilage. The invention provides for the use of the tissue engineered cartilages in the treatment of cartilage degenerative diseases, reconstructive surgery, and cosmetic surgery.
Abstract translation: 软骨已经使用生物降解的电纺聚合物支架构建，该支架用软骨细胞或成体间充质干细胞接种。 已经制备了更特别工程化的软骨，其中软骨具有通过静电纺丝制备的可生物降解和生物相容的纳米纤维聚合物载体和分散在载体孔中的多个软骨细胞或间充质干细胞。 本发明的组织工程软骨具有类似于天然软骨的抗压强度性质。 提供了制备工程组织，包括组织工程软骨的方法，其中提供电纺丝纳米纤维聚合物载体，将载体用细胞溶液处理，并将聚合物 - 细胞混合物在旋转的生物反应器中培养以产生软骨。 本发明提供组织工程软骨在治疗软骨退行性疾病，重建手术和整容手术中的应用。
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3.发明申请Tissue Engineered Cartilage, Method of Making Same, Therapeutic and Cosmetic Surgical Applications Using Same 失效组织工程软骨，相同方法，治疗和美容外科应用使用相同公开(公告)号：US20100061962A1
公开(公告)日：2010-03-11
申请号：US11922251
申请日：2006-06-15
Applicant: Wan-Ju Li
Inventor： Wan-Ju Li
IPC: A61L27/38
CPC classification number: A61Q90/00 , A61L27/18 , A61L27/3817 , A61L27/3852 , A61L27/3895 , A61L27/56 , A61L2400/12 , A61L2430/06 , C08L67/04
Abstract: Cartilage has been constructed using biodegradable electrospun polymeric scaffolds seeded with chondrocytes or adult mesenchymal stem cells. More particularly engineered cartilage has been prepared where the cartilage has a biodegradable and biocompatible nanofibrous polymer support prepared by electrospinning and a plurality of chondocytes or mesenchymal stem cells dispersed in the pores of the support. The tissue engineered cartilages of the invention possess compressive strength properties similar to natural cartilage. Methods of preparing engineered tissues, including tissue engineered cartilages, are provided in which an electrospun nanofibrous polymer support is provided, the support is treated with a cell solution and the polymer-cell mixture cultured in a rotating bioreactor to generate the cartilage. The invention provides for the use of the tissue engineered cartilages in the treatment of cartilage degenerative diseases, reconstructive surgery, and cosmetic surgery.
Abstract translation: 软骨已经使用生物降解的电纺聚合物支架构建，该支架用软骨细胞或成体间充质干细胞接种。 已经制备了更特别工程化的软骨，其中软骨具有通过静电纺丝制备的可生物降解和生物相容的纳米纤维聚合物载体和分散在载体孔中的多个软骨细胞或间充质干细胞。 本发明的组织工程软骨具有类似于天然软骨的抗压强度性质。 提供了制备工程组织，包括组织工程软骨的方法，其中提供电纺丝纳米纤维聚合物载体，将载体用细胞溶液处理，并将聚合物 - 细胞混合物在旋转的生物反应器中培养以产生软骨。 本发明提供组织工程软骨在治疗软骨退行性疾病，重建手术和整容手术中的应用。
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4.发明授权Tissue engineered cartilage, method of making same, therapeutic and cosmetic surgical applications using same 失效组织工程软骨，其制备方法，使用其的治疗和美容手术应用公开(公告)号：US08202551B2
公开(公告)日：2012-06-19
申请号：US11922251
申请日：2006-06-15
Applicant: Wan-Ju Li , Rocky S. Tuan
Inventor： Wan-Ju Li , Rocky S. Tuan
IPC: A01N65/00
CPC classification number: A61Q90/00 , A61L27/18 , A61L27/3817 , A61L27/3852 , A61L27/3895 , A61L27/56 , A61L2400/12 , A61L2430/06 , C08L67/04
Abstract: Cartilage has been constructed using biodegradable electrospun polymeric scaffolds seeded with chondrocytes or adult mesenchymal stem cells. More particularly engineered cartilage has been prepared where the cartilage has a biodegradable and biocompatible nanofibrous polymer support prepared by electrospinning and a plurality of chondocytes or mesenchymal stem cells dispersed in the pores of the support. The tissue engineered cartilages of the invention possess compressive strength properties similar to natural cartilage. Methods of preparing engineered tissues, including tissue engineered cartilages, are provided in which an electrospun nanofibrous polymer support is provided, the support is treated with a cell solution and the polymer-cell mixture cultured in a rotating bioreactor to generate the cartilage. The invention provides for the use of the tissue engineered cartilages in the treatment of cartilage degenerative diseases, reconstructive surgery, and cosmetic surgery.
Abstract translation: 软骨已经使用生物降解的电纺聚合物支架构建，该支架用软骨细胞或成体间充质干细胞接种。 已经制备了更特别工程化的软骨，其中软骨具有通过静电纺丝制备的可生物降解和生物相容的纳米纤维聚合物载体和分散在载体孔中的多个软骨细胞或间充质干细胞。 本发明的组织工程软骨具有类似于天然软骨的抗压强度性质。 提供了制备工程组织，包括组织工程软骨的方法，其中提供电纺丝纳米纤维聚合物载体，将载体用细胞溶液处理，并将聚合物 - 细胞混合物在旋转的生物反应器中培养以产生软骨。 本发明提供组织工程软骨在治疗软骨退行性疾病，重建手术和整容手术中的应用。
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5.发明申请BRAIDED TERTIARY NANOFIBROUS STRUCTURE FOR LIGAMENT, TENDON, AND MUSCLE TISSUE IMPLANT 审中-公开用于大腿，腱和肌肉组织植入物的BRAIDED TERTIARY NANOFIBROUS结构公开(公告)号：US20110190886A1
公开(公告)日：2011-08-04
申请号：US12696245
申请日：2010-01-29
Applicant: Wan-Ju Li
Inventor： Wan-Ju Li
Abstract: A fabricated braided nanofibrous structure having nanofiber bundles that independently have nanofibers oriented in a uniaxial direction and methods of preparing braided nanofibrous structures. More specifically, the braided nanofibrous structures have at least three nanofiber bundles, wherein the nanofiber bundles are braided together and each nanofiber bundle independently includes at least two nanofibers oriented in a uniaxial direction. The braided nanofibrous structures may be inserted into a region of damaged ligament, tendon, or muscle in a subject.
Abstract translation: 具有独立地具有单向取向的纳米纤维的纳米纤维束的制造的编织纳米纤维结构和制备编织纳米纤维结构的方法。 更具体地，编织纳米纤维结构具有至少三个纳米纤维束，其中纳米纤维束被编织在一起，并且每个纳米纤维束独立地包括沿单轴方向取向的至少两个纳米纤维。 编织的纳米纤维结构可以插入受试者的韧带，肌腱或肌肉损伤区域。
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