公开(公告)号：US12268760B2

公开(公告)日：2025-04-08

申请号：US17434800

申请日：2020-03-05

Applicant: Washington University

Inventor： Kevin Bennett ,  Edwin Baldelomar

IPC: A61K51/08 ,  A61K49/14 ,  A61P13/12 ,  C07K14/435 ,  C12N15/62

Abstract: Among the various aspects of the present disclosure is the provision of methods and compositions for detecting recombinant cationic ferritin imaging agents. Also provided are transgenic microorganisms capable of synthesizing a recombinant ferritin imaging agent and methods of making the same. The imaging agents described herein can be used to effectively and noninvasively detect renal pathologies and are suitable for use in a number of imaging modalities.

公开(公告)号：US20230342936A1

公开(公告)日：2023-10-26

申请号：US18305133

申请日：2023-04-21

Applicant: Washington University

Inventor： Kevin Bennett ,  Edwin Baldelomar

IPC: G16H50/30 ,  A61B5/20 ,  G06T7/00 ,  A61B5/055

CPC classification number: G06T7/0016 ,  A61B5/055 ,  A61B5/201 ,  G16H50/30 ,  G06T2207/10016 ,  G06T2207/10088 ,  G06T2207/30084

Abstract: A method of mapping autoregulation of a kidney using magnetic resonance (MR) imaging is provided. The method includes acquiring a time series of MR images of a subject while the subject is at rest by acquiring MR images of an imaging region repeatedly over a period of time by applying a pulse sequence. The imaging region includes at least a kidney of the subject. The method also includes analyzing the time series of MR images along a temporal dimension, and identifying features associated with autoregulation of the kidney including tubuloglomerular feedback (TGF) in voxels of the MR images based on the analysis. The method further includes generating a map and/or a metric of the autoregulation based on the identified features, and outputting the map and/or the metric.