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    LIQUID CHROMATROGRAPHY SYSTEMS AND METHODS
    1.
    发明申请
    LIQUID CHROMATROGRAPHY SYSTEMS AND METHODS 审中-公开
    液相色谱系统和方法

    公开(公告)号：US20140306105A1

    公开(公告)日：2014-10-16

    申请号：US14248662

    申请日：2014-04-09

    Applicant: Waters Technologies Corporation

    Inventor： Jeremy D. Netto ,  Mark Ritchie

    IPC: G01N30/16 ,  H01J49/26

    CPC classification number: H01J49/26 ,  B01D15/14 ,  B01D15/166 ,  B01D15/1864 ,  B01D15/1871 ,  B01D15/1878 ,  B01D15/305 ,  B01D15/325 ,  G01N30/08 ,  G01N30/461 ,  G01N30/462 ,  G01N30/463 ,  G01N30/468 ,  G01N30/72 ,  G01N30/7233 ,  G01N2030/085 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/347 ,  G01N2030/382 ,  G01N2030/385 ,  G01N2030/388

    Abstract: One aspect of the invention provides a liquid chromatography system including: a first solvent manager configured to dispense various ratios of a first solvent and a second solvent; a first column in fluid communication with the first solvent manager; a mixer in fluid communication with the first column; a first valve in fluid communication with the mixer; a second column having a first end in fluid communication with a first port of the first valve and a second end in fluid communication with a second port of the first valve; a second solvent manager adapted and configured to dispense various ratios of a third solvent and a fourth solvent; and a second valve in fluid communication with the second solvent manager, the first valve, and the mixer. The first valve and the second valve are adapted and configured for actuation between and a second position. In the first position: solvent dispensed by the first solvent manager and an injected sample flow over the first column; eluent from the first column is mixed with solvent dispensed by the second solvent manager in the mixer to produce a combined mobile phase; and the combined mobile phase is passed through the first valve and over the second column in a first direction to trap analytes of interest on the first column. In the second position, solvent dispensed by the second solvent manager is passed over the second column in a second direction to release the analytes of interest from the second column.

    Abstract translation: 本发明的一个方面提供一种液相色谱系统，其包括：配置成分配第一溶剂和第二溶剂的各种比例的第一溶剂管理器; 与第一溶剂管理器流体连通的第一列; 与第一列流体连通的混合器; 与混合器流体连通的第一阀; 第二柱，其具有与第一阀的第一端口流体连通的第一端和与第一阀的第二端口流体连通的第二端; 适于并构造成分配第三溶剂和第四溶剂的各种比例的第二溶剂管理器; 以及与第二溶剂管理器，第一阀和混合器流体连通的第二阀。 第一阀和第二阀适于和构造成用于在第二位置和第二位置之间致动。 在第一位置：由第一溶剂管理器分配的溶剂和在第一塔上注入的样品流; 将来自第一列的洗脱液与混合器中由第二溶剂管理器分配的溶剂混合以产生组合的流动相; 并且组合的流动相在第一方向上通过第一阀并在第二柱上方，以捕集第一列上的感兴趣的分析物。 在第二位置，通过第二溶剂管理器分配的溶剂在第二方向上通过第二柱，以从第二柱释放感兴趣的分析物。

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