公开(公告)号：US20100264617A1

公开(公告)日：2010-10-21

申请号：US12824462

申请日：2010-06-28

Applicant: Ashley Thomas Dudding ,  William Wilson ,  Brent Collyer ,  Jerorne Lim Cortez ,  Patrick Williams

Inventor： Ashley Thomas Dudding ,  William Wilson ,  Brent Collyer ,  Jerorne Lim Cortez ,  Patrick Williams

IPC: B60G11/00 ,  B60G11/04

CPC classification number: B60G11/113 ,  B60G2202/112 ,  B60G2204/4306 ,  B60G2206/428 ,  Y10T428/24

Abstract: A clamp assembly of a vehicle leaf spring suspension is disclosed. The clamp assembly has an axle bracket secured to a vehicle axle and a top cap secured to the axle bracket by mechanical fasteners to define an axle seat. The axle bracket and top cap may include interlocking keys and keyways to cooperate with the mechanical fasteners in transmitting the load from the vehicle axle. A spring seat of the leaf spring is received within the axle seat and is tapered. The tapered spring seat, when combined with a deformable liner in the axle seat, effectively eliminates the inactive portion of the leaf spring to increase the effective length of the spring and minimize the spring rate.

Abstract translation: 公开了一种车辆弹簧悬架的夹紧组件。 夹具组件具有固定到车辆车轴的车轴支架和通过机械紧固件固定到车轴支架以限定轴座的顶盖。 轴支架和顶盖可以包括互锁键和键槽，以与机械紧固件配合以从车辆轴传输负载。 板簧的弹簧座被容纳在轴座内并且是锥形的。 当与轴座中的可变形衬套组合时，锥形弹簧座有效地消除了板簧的非活动部分，以增加弹簧的有效长度并使弹簧刚度最小化。

公开(公告)号：US20100038877A1

公开(公告)日：2010-02-18

申请号：US11919534

申请日：2006-04-26

Applicant: Jerome Lim Cortez ,  Jason Steby Thomas ,  Ashley Thomas Dudding ,  William Wilson ,  Gregory Lewis McClain ,  Brent Collyer

Inventor： Jerome Lim Cortez ,  Jason Steby Thomas ,  Ashley Thomas Dudding ,  William Wilson ,  Gregory Lewis McClain ,  Brent Collyer

IPC: B60G11/00

CPC classification number: B60G11/113 ,  B60G11/12 ,  B60G11/465 ,  B60G2200/31 ,  B60G2202/112 ,  B60G2204/121 ,  B60G2204/148 ,  B60G2204/4306 ,  B60G2206/30 ,  B60G2206/8201

Abstract: A vehicle leaf spring suspension having a low spring rate is disclosed. The suspension has an axle seat secured to a vehicle axle. The leaf spring is clamped at its spring seat area to the axle seat at the clamp group mounting surface of the axle seat and with certain of the disclosed axle seats, can be clamped such that the spring seat area is asymmetrically positioned with respect to the vehicle axle centerline. Also, an active clamp group arrangement can be used to utilize the entire physical length of the leaf spring.

Abstract translation: 公开了一种具有低弹簧刚度的车辆弹簧悬架。 悬架具有固定到车轴的轴座。 板簧在其弹簧座区域处被夹紧在轴座的夹具组安装表面处的轴座处，并且可以夹紧某些公开的轴座，使得弹簧座区域相对于车辆不对称地定位 轴心线。 此外，可以使用有源钳组布置来利用板簧的整个物理长度。

公开(公告)号：US20080070886A1

公开(公告)日：2008-03-20

申请号：US11830668

申请日：2007-07-30

Applicant: William Wilson ,  Bronwyn Siim

Inventor： William Wilson ,  Bronwyn Siim

IPC: A61K31/35 ,  A61K31/505 ,  A61K31/555 ,  A61P43/00

CPC classification number: A61K31/66 ,  A61K31/352 ,  A61K31/4353 ,  A61K31/475 ,  A61K31/505 ,  A61K31/65 ,  A61K31/70 ,  A61K31/7034 ,  A61K33/24 ,  A61K2300/00

Abstract: The present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from platinum compounds, vinca alkaloids, alkylating agents, anthracyclines, topoisomerase I inhibitors, antimetabolites and topoisomerase II inhibitors, which have anti-tumour activity. Preferably, the present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from carboplatin, gemcitabine, cisplatin, 5-fluorouracil, cyclophosphamide, etoposide, vincristine, doxorubicin and irinotecan. More particularly, the invention is concerned with the use of such combinations in the treatment of cancer and pharmaceutical compositions containing such combinations. The invention further provides for methods of preparing the combinations of the invention.

公开(公告)号：US20080070847A1

公开(公告)日：2008-03-20

申请号：US11830650

申请日：2007-07-30

Applicant: William Wilson ,  Bronwyn Siim

Inventor： William Wilson ,  Bronwyn Siim

IPC: A61K31/7034 ,  A61K31/352 ,  A61K31/4353 ,  A61K31/505 ,  A61P35/00 ,  A61K31/65 ,  A61K31/66

CPC classification number: A61K31/66 ,  A61K31/352 ,  A61K31/4353 ,  A61K31/475 ,  A61K31/505 ,  A61K31/65 ,  A61K31/70 ,  A61K31/7034 ,  A61K33/24 ,  A61K2300/00

Abstract: The present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from platinum compounds, vinca alkaloids, alkylating agents, anthracyclines, topoisomerase I inhibitors, antimetabolites and topoisomerase II inhibitors, which have anti-tumour activity. Preferably, the present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from carboplatin, gemcitabine, cisplatin, 5-fluorouracil, cyclophosphamide, etoposide, vincristine, doxorubicin and irinotecan. More particularly, the invention is concerned with the use of such combinations in the treatment of cancer and pharmaceutical compositions containing such combinations. The invention further provides for methods of preparing the combinations of the invention.

Abstract translation: 本发明涉及化合物5,6-二甲基呫吨酮-4-乙酸（DMXAA）与选自铂化合物，长春花生物碱，烷化剂，蒽环类，拓扑异构酶I抑制剂，抗代谢物和拓扑异构酶II抑制剂的化合物的协同组合，其中 具有抗肿瘤活性。 优选地，本发明涉及化合物5,6-二甲基呫吨酮-4-乙酸（DMXAA）和选自卡铂，吉西他滨，顺铂，5-氟尿嘧啶，环磷酰胺，依托泊苷，长春新碱，多柔比星和伊立替康的化合物的协同组合。 更具体地，本发明涉及这样的组合在治疗癌症中的用途以及含有这些组合的药物组合物。 本发明进一步提供了制备本发明组合的方法。

公开(公告)号：US20070166944A1

公开(公告)日：2007-07-19

申请号：US11324432

申请日：2006-01-04

Applicant: Robert Japp ,  John Lauffer ,  Voya Markovich ,  William Wilson

Inventor： Robert Japp ,  John Lauffer ,  Voya Markovich ,  William Wilson

IPC: H01L21/20

CPC classification number: H05K3/4641 ,  H05K3/429 ,  H05K2203/068

Abstract: A method of making a circuitized substrate and an electrical assembly utilizing same in which the substrate is comprised of at least two sub-composites in which the dielectric material of at least one of these sub-composites is heated during bonding (e.g., lamination) to the other sufficiently to cause the dielectric material to flow into and substantially fill openings in a conductive layer for the bonded structure. Conductive thru-holes are formed within the bonded structure to couple selected ones of the structure's conductive layers. Formation of an electrical assembly is possible by positioning one or more electrical components (e.g., semiconductor chips or chip carriers) on the final structure and electrically coupling these to the structure's external circuitry.

Abstract translation: 一种制造电路化基板的方法和使用其的电气组件，其中基板由至少两个亚复合材料构成，其中这些亚复合材料中的至少一个的介电材料在粘合（例如，层压）期间被加热到 另一个足以使电介质材料流入并基本上填充用于接合结构的导电层中的开口。 导电通孔形成在接合结构内，以耦合所选择的结构导电层。 通过将一个或多个电气部件（例如，半导体芯片或芯片载体）定位在最终结构上并将其电耦合到结构的外部电路，可以形成电组件。

公开(公告)号：US20070032455A1

公开(公告)日：2007-02-08

申请号：US10577078

申请日：2004-10-29

Applicant: William Denny ,  Graham Atwell ,  Shangjin Yang ,  William Wilson ,  Adam Patterson ,  Nuala Helsby

Inventor： William Denny ,  Graham Atwell ,  Shangjin Yang ,  William Wilson ,  Adam Patterson ,  Nuala Helsby

IPC: A61K31/675 ,  C07F9/02 ,  A61K31/66

CPC classification number: C07F9/091 ,  C07C237/32 ,  C07C309/66 ,  C07C317/48 ,  C07D203/14

Abstract: The present invention relates to a novel nitrophenyl mustard and nitrophenylaziridine alcohols, to their corresponding phosphates, to their use as targeted cytotoxic agents; as bioreductive drugs in hypoxic tumours, and to their use in cell ablation, including gene-directed enzyme-prodrug therapy (GDEPT) and antibody-directed enzymeprodrug therapy (ADEPT), in conjunction with nitroreductase enzymes.

Abstract translation: 本发明涉及一种新的硝基苯基芥子和硝基苯基氮丙啶醇，以及它们相应的磷酸盐，用作靶向的细胞毒剂; 作为缺氧性肿瘤中的生物还原药物，以及其在细胞消融中的应用，包括基因定向酶前药治疗（GDEPT）和抗体定向酶法（ADEPT），与硝酸还原酶联用。

公开(公告)号：US20070019692A1

公开(公告)日：2007-01-25

申请号：US11204398

申请日：2005-08-16

Applicant: Kazuya Kogure ,  Aaron Wegner ,  William Wilson

Inventor： Kazuya Kogure ,  Aaron Wegner ,  William Wilson

IPC: H01S3/04 ,  H01S3/08

CPC classification number: H01S5/0612 ,  G03H1/0248 ,  G03H2001/0489 ,  G11B7/0065 ,  G11B7/126

Abstract: A semiconductor laser device, with a semiconductor laser element operable to oscillate and output a laser beam, is provided with a heat generation unit operable to generate heat so as to regulate the temperature of the semiconductor laser element, a laser beam splitting unit operable to split a laser beam, oscillated and output from the semiconductor laser element, into first and second beams each forming an optical path different from each other, and a heat generation control unit operable to control the amount of heat generated by the heat generation unit so as to maintain constant a fringe spacing between interference fringes with a plurality of fringes obtained as a result of the interference between the first and second beams.

Abstract translation: 具有可操作以振荡和输出激光束的半导体激光元件的半导体激光装置设置有可发生热量以便调节半导体激光元件的温度的发热单元，可操作地分裂的激光束分离单元 从半导体激光元件振荡并输出的激光束分别形成彼此不同的光路的第一和第二光束;以及发热控制单元，其可操作以控制由发热体单元产生的热量，从而 在干涉条纹与作为第一和第二光束之间的干涉的结果获得的多个条纹之间保持恒定的条纹间距。

公开(公告)号：US20060170462A1

公开(公告)日：2006-08-03

申请号：US11047388

申请日：2005-01-31

Applicant: Dipankar Bhattacharya ,  John Kriz ,  Bernard Morris ,  William Wilson

Inventor： Dipankar Bhattacharya ,  John Kriz ,  Bernard Morris ,  William Wilson

IPC: H03K5/22

CPC classification number: H03K3/02337 ,  H03K3/3565

Abstract: A comparator circuit includes a reference generator connecting to a first source providing a first voltage. The reference generator is operative to generate a reference signal and includes a control circuit selectively operable in at least a first mode or a second mode in response to a first control signal, wherein in the first mode the reference signal is not generated, and in the second mode the reference generator is operative to generate the reference signal. The comparator circuit further includes a comparator connecting to a second source providing a second voltage, the second voltage being less than the first voltage. The comparator is operative to receive the reference signal and an input signal, and to generate an output signal which is a function of a comparison between the input signal and the reference signal. A hysteresis circuit is included in the comparator circuit for selectively controlling a switching threshold of the comparator, relative to the input signal, as a function of the output signal of the comparator. The comparator circuit includes a voltage clamp operative to limit a voltage applied to one or more devices in the control circuit, the comparator, and/or the hysteresis circuit to less than the second voltage.

Abstract translation: 比较器电路包括连接到提供第一电压的第一源的参考发生器。 参考发生器用于产生参考信号并且包括响应于第一控制信号选择性地以至少第一模式或第二模式操作的控制电路，其中在第一模式中不产生参考信号，并且在 第二模式，参考发生器用于产生参考信号。 比较器电路还包括连接到提供第二电压的第二源的比较器，第二电压小于第一电压。 比较器用于接收参考信号和输入信号，并且产生作为输入信号和参考信号之间的比较的函数的输出信号。 比较器电路中包括滞后电路，用于根据比较器的输出信号选择性地控制比较器相对于输入信号的切换阈值。 比较器电路包括电压钳位器，用于将施加到控制电路，比较器和/或滞后电路中的一个或多个器件的电压限制为小于第二电压。

公开(公告)号：US20050252857A1

公开(公告)日：2005-11-17

申请号：US11110598

申请日：2005-04-19

Applicant: William Wilson ,  Charlene Schaldach ,  William Bourcier ,  Phillip Paul

Inventor： William Wilson ,  Charlene Schaldach ,  William Bourcier ,  Phillip Paul

IPC: B01D61/42 ,  B01D61/44 ,  B01D61/52 ,  B01D67/00 ,  B03C5/02 ,  C02F1/469 ,  G01N27/40 ,  G01N27/44 ,  B01D61/20

CPC classification number: B01D61/44 ,  B01D61/52 ,  B01D67/003 ,  B01D67/0034 ,  B01D67/0062 ,  B01D2325/20 ,  B01D2325/26 ,  B03C5/026 ,  B82Y30/00 ,  C02F1/469 ,  C02F1/4696 ,  C02F2101/103 ,  C02F2101/163 ,  C02F2305/08

Abstract: A computer designed nanoengineered membrane for separation of dissolved species. One embodiment provides an apparatus for treatment of a fluid that includes ions comprising a microengineered porous membrane, a system for producing an electrical charge across the membrane, and a series of nanopores extending through the membrane. The nanopores have a pore size such that when the fluid contacts the membrane, the nanopores will be in a condition of double layer overlap and allow passage only of ions opposite to the electrical charge across the membrane.

Abstract translation: 一种计算机设计的用于分离溶解物种的纳米工程膜。 一个实施例提供了一种用于处理流体的装置，该装置包括离子，该离子包括微工程多孔膜，用于在该膜上产生电荷的系统以及延伸穿过膜的一系列纳米孔。 纳米孔具有这样的孔径，使得当流体接触膜时，纳米孔将处于双层重叠的状态，并允许仅通过与膜电荷相反的离子。

公开(公告)号：US06924421B1

公开(公告)日：2005-08-02

申请号：US10271834

申请日：2002-10-15

Applicant: William Wilson

Inventor： William Wilson

IPC: A01H1/00 ,  A01H1/02 ,  A01H5/00 ,  A01H5/10 ,  C12N5/04

CPC classification number: A01H5/10

Abstract: According to the invention, there is provided a hybrid maize plant, designated as 34D71, produced by crossing two Pioneer Hi-Bred International, Inc. proprietary inbred maize lines. This invention relates to the hybrid seed 34D71, the hybrid plant produced from the seed, and variants, mutants, and trivial modifications of hybrid 34D71. This invention also relates to methods for producing a maize plant containing in its genetic material one or more transgenes and to the transgenic maize plants produced by that method. This invention further relates to methods for producing maize lines derived from hybrid maize line 34D71 and to the maize lines derived by the use of those methods.

Abstract translation: 根据本发明，提供了一种称为34D71的杂交玉米植物，其通过两个先驱Hi-Bred International，Inc.专有的近交玉米品系进行生产。 本发明涉及混合种子34D71，从种子产生的杂种植物，以及杂种34D71的变体，突变体和平凡的修饰。 本发明还涉及在其遗传物质中含有一种或多种转基因的玉米植物和通过该方法生产的转基因玉米植物的方法。 本发明还涉及用于生产源自杂交玉米系34D71的玉米品系的方法以及通过使用这些方法得到的玉米品系。