公开(公告)号：US12280177B2

公开(公告)日：2025-04-22

申请号：US17388652

申请日：2021-07-29

Applicant: Wisconsin Alumni Research Foundation ,  ARKANSAS STATE UNIVERSITY—JONESBORO ,  Worcester Polytechnic Institute

Inventor： William L. Murphy ,  Gianluca Fontana ,  Joshua Gershlak ,  Glenn Gaudette ,  Pam Weathers ,  Tanja Dominko ,  Marsha Rolle ,  Sarah Hernandez ,  Carol Cramer ,  Luis Fabircio Medina-Bolivar ,  Bernard Binder

IPC: A61L27/36 ,  A61L27/12 ,  A61L27/22 ,  A61L27/38 ,  A61L27/54 ,  C12N5/00 ,  C12N5/04

Abstract: Decellularized plant tissues and the use of these plant tissues as scaffolds are disclosed herein. Particularly, decellularized plant tissues are functionalized such to allow for human cell adhesion, thereby allowing for their use as scaffolds for human cells. These scaffolds can then be used in a number of applications/markets, including as research tools for tissue engineering, regenerative medicine, and basic cellular biology.

公开(公告)号：US20200016297A1

公开(公告)日：2020-01-16

申请号：US16585698

申请日：2019-09-27

Applicant: Worcester Polytechnic Institute

Inventor： Marsha Rolle ,  Fioleda Prifti ,  Christopher Malcuit ,  Terri Anne Camesano ,  Tanja Dominko ,  Denis Kole ,  Destin Heilman

IPC: A61L27/54 ,  C07K14/78 ,  C07K14/47 ,  C12N15/62

Abstract: The invention provides a scaffold of extracellular matrix polymers with recombinant chimeric peptides tethered thereto. The invention also provides recombinant chimeric peptides of antimicrobial peptides and extracellular matrix binding domains. The invention also provides methods for treating chronic wounds using the scaffold and/or recombinant chimeric peptides.

公开(公告)号：US20160168647A1

公开(公告)日：2016-06-16

申请号：US14966539

申请日：2015-12-11

Applicant: Worcester Polytechnic Institute

Inventor： Sarah Hernandez ,  Tanja Dominko

IPC: C12Q1/68 ,  G01N33/574 ,  A61B18/02 ,  C12N9/10

CPC classification number: C12Q1/6886 ,  A61B18/02 ,  C12N9/1007 ,  C12Q2600/158 ,  G01N33/57496 ,  G01N2333/91011

Abstract: The invention features compositions and methods for a pre-cancer prognostic screen.

Abstract translation: 本发明的特征在于用于癌前预后筛选的组合物和方法。

公开(公告)号：US20190390281A1

公开(公告)日：2019-12-26

申请号：US16414746

申请日：2019-05-16

Applicant: Worcester Polytechnic Institute

Inventor： Sarah Hernandez ,  Tanja Dominko

IPC: C12Q1/6886 ,  C12N9/10 ,  G01N33/574

Abstract: The invention features compositions and methods for a pre-cancer prognostic screen.

公开(公告)号：US20140322785A1

公开(公告)日：2014-10-30

申请号：US14273932

申请日：2014-05-09

Applicant: Worcester Polytechnic Institute

Inventor： Christopher R. Lambert ,  W. Grant McGimpsey ,  Raymond L. Page ,  Tanja Dominko

IPC: C12N11/14

CPC classification number: C12N11/14 ,  C12M21/02 ,  C12M21/08 ,  C12M25/16 ,  C12M35/06 ,  C12N1/12 ,  C12N5/0062 ,  C12N13/00 ,  C12N2513/00 ,  C12N2521/00 ,  C12N2529/00 ,  C12N2531/00

Abstract: The invention provides methods for rapid, continuous generation of cells and cell products using magnetically stabilized three-dimensional tissue culture. The invention also pertains to a continuous flow self-regulating closed system bioreactor system for magnetically stabilized three-dimensional tissue culture. The methods described here do not use traditional solid scaffolding for cell culture.

Abstract translation: 本发明提供了使用磁稳定的三维组织培养物快速，连续地产生细胞和细胞产物的方法。 本发明还涉及一种用于磁稳定三维组织培养的连续流动自调节闭合系统生物反应器系统。 这里描述的方法不使用传统的固体支架进行细胞培养。