公开(公告)号：US20040004193A1

公开(公告)日：2004-01-08

申请号：US10189886

申请日：2002-07-03

Applicant: Xenogen Corporation

Inventor： David Nilson ,  Brad Rice

IPC: G01N021/64

CPC classification number: G01N21/6456 ,  A01K1/031 ,  A61M16/104 ,  A61M16/18 ,  A61M16/202 ,  A61M2016/0039 ,  G01N2021/6463 ,  G01N2021/6484

Abstract: A fluorescence imaging assembly including an imaging apparatus having an enclosure wall defining a view port into a light-tight imaging compartment thereof. A specimen platform is positioned in the imaging compartment having a support surface facing toward the view port. An illumination assembly includes a light source and a frame disposed in the imaging compartment. The illumination assembly is positioned proximate to and substantially peripherally encircling the view port. A bundle of fiber optic strands extends into the imaging compartment wherein proximal ends of the strands are in optical communication with the light source and distal ends thereof terminate at the frame to emit a conical directional beam of light onto the specimen platform. The distal ends of the fiber optic strands are sufficiently spaced peripherally about the view port such that the plurality of directional beams collectively illuminate the specimen platform in a substantially uniform manner.

Abstract translation: 一种荧光成像组件，包括成像装置，该成像装置具有将视口插入其不透光成像室的外壳壁。 样本平台位于成像室中，其具有面向观察端口的支撑表面。 照明组件包括光源和设置在成像室中的框架。 照明组件靠近并基本上周边环绕视口。 一束光纤股线延伸到成像室中，其中股线的近端与光源光学连通，并且其远端终止在框架处以向样本平台上发射圆锥形的定向光束。 光纤束的远端围绕视口被充分地间隔开，使得多个定向光束以基本均匀的方式共同照射样本平台。

公开(公告)号：US20030187344A1

公开(公告)日：2003-10-02

申请号：US10372763

申请日：2003-02-21

Applicant: XENOGEN CORPORATION

Inventor： David Nilson ,  Brad Rice ,  Tamara Troy

IPC: A61B005/05

CPC classification number: G01N21/6456 ,  A01K1/031 ,  A61M16/104 ,  A61M16/18 ,  A61M16/202 ,  A61M2016/0039 ,  G01N2021/1787 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0227 ,  G01N2201/0826

Abstract: A macroscopic fluorescence illumination assembly is provided for use with an imaging apparatus with a light-tight imaging compartment. The imaging apparatus includes an interior wall defining a view port extending into the imaging compartment to enable viewing of a specimen contained therein. The illumination assembly includes a specimen support surface sized and dimensioned for receipt in the imaging compartment, and oriented to face toward the view port of the imaging apparatus. The support surface is substantially opaque and defines a window portion that enables the passage of light there through. The window portion is selectively sized and dimensioned such that the specimen, when supported atop the support surface, can be positioned and seated over the window portion in a manner forming a light-tight seal substantially there between. The illumination assembly further includes an excitation light source, and a bundle of fiber optic strands having proximal ends thereof in optical communication with the light source. The distal ends of the strands terminate proximate the window portion of the support surface. The distal ends each emit a respective beam of light originating from the light source which are then collectively directed toward the window portion and into a bottom side of the specimen wherein the diffused light passes there through and exits a topside thereof for receipt through the view port to view the fluorescence of the specimen.

Abstract translation: 提供了一种宏观荧光照明组件，用于与具有不透光成像室的成像装置一起使用。 该成像设备包括限定了一个视图端口的内壁，该视图端口延伸到成像室中以使得能够观察其中容纳的样本。 照明组件包括尺寸和尺寸适于接收在成像室中的样本支撑表面，并且被定向成面向成像设备的视口。 支撑表面基本上是不透明的，并且限定了能够使光通过的窗口部分。 窗口部分被选择性地定尺寸和尺寸使得当被支撑在支撑表面上方时，样本可以以基本上在其之间形成不透光密封的方式被定位和安置在窗口部分上。 照明组件还包括激发光源，以及一束光纤束，其光纤束的近端与光源光学连通。 股线的末端终止于支撑表面的窗口部分。 远端各自发出源自光源的相应光束，然后将它们共同指向窗口部分并进入样本的底侧，其中漫射光通过其并穿过其顶侧并通过观察端口接收 以观察样品的荧光。