公开(公告)号：US08883782B2

公开(公告)日：2014-11-11

申请号：US13047734

申请日：2011-03-14

Applicant: Yuan Cheng ,  Ryan White ,  Albert Amegadzie ,  James Brown ,  Alan C. Cheng ,  Erin F. Dimauro ,  Thomas Dineen ,  Oleg Epstein ,  Vijay Keshav Gore ,  Jason Brooks Human ,  Ted Judd ,  Charles Kreiman ,  Qingyian Liu ,  Patricia Lopez ,  Vu Van Ma ,  Isaac Marx ,  Ana Minatti ,  Hanh Nho Nguyen ,  Nick A. Paras ,  Vinod F. Patel ,  Wenyuan Qian ,  Matthew Weiss ,  Qiufen Xue ,  Xiao Mei Zheng ,  Wenge Zhong

Inventor： Yuan Cheng ,  Ryan White ,  Albert Amegadzie ,  James Brown ,  Alan C. Cheng ,  Erin F. Dimauro ,  Thomas Dineen ,  Oleg Epstein ,  Vijay Keshav Gore ,  Jason Brooks Human ,  Ted Judd ,  Charles Kreiman ,  Qingyian Liu ,  Patricia Lopez ,  Vu Van Ma ,  Isaac Marx ,  Ana Minatti ,  Hanh Nho Nguyen ,  Nick A. Paras ,  Vinod F. Patel ,  Wenyuan Qian ,  Matthew Weiss ,  Qiufen Xue ,  Xiao Mei Zheng ,  Wenge Zhong

IPC: A61K31/42 ,  A61K31/422 ,  A61K31/506 ,  A61K31/4439 ,  A61K31/5377 ,  C07D221/20 ,  C07D235/02 ,  C07D263/08 ,  C07D295/135 ,  C07D491/10 ,  C07D498/10

CPC classification number: C07D491/10 ,  A61K31/42 ,  A61K31/422 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/5377 ,  C07D221/20 ,  C07D235/02 ,  C07D263/08 ,  C07D295/135 ,  C07D498/10 ,  C07D498/20 ,  C07D513/10 ,  C09B11/28

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and other related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, R2, R7, X and Y of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.

Abstract translation: 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默氏病（AD））和其它相关病症的新一类化合物。 在一个实施方案中，化合物具有通式I，其中式I中的A1，A2，A3，A4，A5，A6，R2，R7，X和Y如本文所定义。 本发明还包括在药物组合物中用于治疗，预防或治疗与β-分泌酶蛋白活性相关的病症和病症的用途。 这种病症包括例如阿尔茨海默氏病，认知缺陷，认知障碍，精神分裂症和与脑上形成和/或沉积斑块相关和/或引起的其他中枢神经系统病症。 本发明还包括式I的其它实施方案，可用于制备式I化合物的中间体和方法。

公开(公告)号：US08178557B2

公开(公告)日：2012-05-15

申请号：US12157303

申请日：2008-06-09

Applicant: Michele Potashman ,  Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Yuan Cheng ,  Joseph L. Kim ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Jean-Christophe Harmange ,  George Borg ,  Matthew Weiss ,  Brian L. Hodous ,  Russell Graceffa ,  William H. Buckner ,  Craig E. Masse ,  Deborah Choquette ,  Matthew W. Martin ,  Julie Germain ,  Lucian V. DiPietro ,  Stuart C. Chaffee ,  Joseph J. Nunes ,  John L. Buchanan ,  David C. McGowan ,  Douglas A. Whittington ,  Gregory J. Habgood ,  Vinod F. Patel ,  Daniel La

Inventor： Michele Potashman ,  Tae-Seong Kim ,  Steven Bellon ,  Shon Booker ,  Yuan Cheng ,  Joseph L. Kim ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu ,  Jean-Christophe Harmange ,  George Borg ,  Matthew Weiss ,  Brian L. Hodous ,  Russell Graceffa ,  William H. Buckner ,  Craig E. Masse ,  Deborah Choquette ,  Matthew W. Martin ,  Julie Germain ,  Lucian V. DiPietro ,  Stuart C. Chaffee ,  Joseph J. Nunes ,  John L. Buchanan ,  David C. McGowan ,  Douglas A. Whittington ,  Gregory J. Habgood ,  Vinod F. Patel ,  Daniel La

IPC: A61K31/04

CPC classification number: C07D213/64 ,  C07D213/81 ,  C07D215/233 ,  C07D215/38 ,  C07D215/48 ,  C07D215/54 ,  C07D237/34 ,  C07D239/34 ,  C07D239/47 ,  C07D239/84 ,  C07D239/94 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Abstract translation: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US08078857B2

公开(公告)日：2011-12-13

申请号：US12165886

申请日：2008-07-01

Applicant: Yuan Cheng ,  Hua Feng Hong ,  Min Qu ,  Xing Wei ,  Xiao Bing Yan

Inventor： Yuan Cheng ,  Hua Feng Hong ,  Min Qu ,  Xing Wei ,  Xiao Bing Yan

IPC: G06F9/00 ,  G06F9/24 ,  G06F15/177

CPC classification number: G06F9/44521

Abstract: The invention provides a system and method for adaptively loading frequently loaded dynamic link libraries. The system comprises: a monitor for monitoring loading events of dynamic link libraries while an operating system is running, and logging a name and related loading information of the corresponding dynamic link library into a log file in response to the loading events; and an invoker for automatically loading at least one of the most frequently loaded dynamic link libraries logged in the log file upon a subsequent startup of the operating system. By using the system and method, startup performance of the most frequently used applications can be greatly improved.

Abstract translation: 本发明提供一种用于自适应地加载经常加载的动态链接库的系统和方法。 该系统包括：用于在操作系统运行时监视动态链接库的加载事件的监视器，并且响应于加载事件将对应的动态链接库的名称和相关加载信息记录到日志文件中; 以及在随后启动操作系统时自动加载日志文件中记录的最频繁加载的动态链接库中的至少一个的调用者。 通过使用系统和方法，可以大大提高最常用的应用程序的启动性能。

公开(公告)号：US07880000B2

公开(公告)日：2011-02-01

申请号：US11126000

申请日：2005-05-09

Applicant: Stephanie D. Geuns-Meyer ,  Brian L. Hodous ,  Stuart C. Chaffee ,  Paul A. Tempest ,  Philip R. Olivieri ,  Rebecca E. Johnson ,  Brian K. Albrecht ,  Vinod F. Patel ,  Victor J. Cee ,  Joseph L. Kim ,  Steven Bellon ,  Xiaotian Zhu ,  Yuan Cheng ,  Ning Xi ,  Karina Romero ,  Hanh Nho Nguyen ,  Holly L. Deak

Inventor： Stephanie D. Geuns-Meyer ,  Brian L. Hodous ,  Stuart C. Chaffee ,  Paul A. Tempest ,  Philip R. Olivieri ,  Rebecca E. Johnson ,  Brian K. Albrecht ,  Vinod F. Patel ,  Victor J. Cee ,  Joseph L. Kim ,  Steven Bellon ,  Xiaotian Zhu ,  Yuan Cheng ,  Ning Xi ,  Karina Romero ,  Hanh Nho Nguyen ,  Holly L. Deak

IPC: C07D401/14 ,  C07D403/14 ,  A61K31/53 ,  A61K31/4427 ,  A61K31/506 ,  A61P19/02 ,  A61P35/00

CPC classification number: C07D213/73 ,  C07D239/42 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D471/04

Abstract: The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other poliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.

Abstract translation: 本发明涉及具有通式I的化合物，其中A，B，D，E，G，H1-5和R1-4在本文中定义，以及能够调节各种蛋白激酶受体酶的合成中间体， 从而影响与这些激酶的活性相关的各种疾病状态和状况。 例如，这些化合物能够调节激酶，从而影响血管生成过程并治疗血管生成相关疾病和其它包括癌症和炎症的复发性疾病。 本发明还包括药物组合物，包括该化合物，以及治疗与蛋白激酶活性有关的疾病状态的方法。

公开(公告)号：US07872009B2

公开(公告)日：2011-01-18

申请号：US11600264

申请日：2006-11-14

Applicant: Brian K. Albrecht ,  Denise Lyn Andersen ,  Michael Bartberger ,  James Brown ,  Ryan Brown ,  Stuart C. Chaffee ,  Yuan Cheng ,  Michael Croghan ,  Russell Graceffa ,  Scott Harried ,  Stephen Hitchcock ,  Randall Hungate ,  Ted Judd ,  Matthew Kaller ,  Charles Kreiman ,  Daniel La ,  Patricia Lopez ,  Craig Masse ,  Holger Monenschein ,  Thomas Nguyen ,  Thomas Nixey ,  Vinod F. Patel ,  Lewis Pennington ,  Matthew Weiss ,  Qiufen Xue ,  Bryant Yang ,  Wenge Zhong

Inventor： Brian K. Albrecht ,  Denise Lyn Andersen ,  Michael Bartberger ,  James Brown ,  Ryan Brown ,  Stuart C. Chaffee ,  Yuan Cheng ,  Michael Croghan ,  Russell Graceffa ,  Scott Harried ,  Stephen Hitchcock ,  Randall Hungate ,  Ted Judd ,  Matthew Kaller ,  Charles Kreiman ,  Daniel La ,  Patricia Lopez ,  Craig Masse ,  Holger Monenschein ,  Thomas Nguyen ,  Thomas Nixey ,  Vinod F. Patel ,  Lewis Pennington ,  Matthew Weiss ,  Qiufen Xue ,  Bryant Yang ,  Wenge Zhong

IPC: A61K31/50

CPC classification number: C07D405/12 ,  C07D413/12

Abstract: The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Abstract translation: 本发明包括可用于调节β-分泌酶酶活性和用于治疗β-分泌酶介导的疾病（包括阿尔茨海默病（AD））和相关病症的新一类化合物。 在一个实施方案中，化合物具有通式I，其中A，B，R 3，R 4，R 5，i和j在本文中定义。 本发明还包括药物组合物，其包括一种或多种式I化合物，这些化合物的使用方法，包括治疗AD和相关疾病，通过给受试者施用式I化合物或包含它们的组合物。 本发明还包括式II和III的其它实施方案，可用于制备本发明化合物的中间体和方法。

公开(公告)号：US20060205331A1

公开(公告)日：2006-09-14

申请号：US11079770

申请日：2005-03-14

Applicant: Donald Gringer ,  Yuan Cheng

Inventor： Donald Gringer ,  Yuan Cheng

IPC: B24D11/00

CPC classification number: B24D15/04

Abstract: A sander comprises a body member molded of polypropylene to which a soft pad member is integrally molded or directly bonded thereto. Preferably, the material comprising the pad member is of a thermoplastic elastomer material, such as Santoprene®. Significantly, when the pad member is molded directly to the body member, the pad has internal dimensions only slightly larger than the external dimensions of the body member so that, when the body member is located within the confines of the pad member, a secure fit is formed between these two members, without any space between them. Further, the respective dimensions of the body member and pad member give the sander a thick, one-piece appearance in side and end views. The pad member may also include a plurality of openings which help provide a “spongy” effect to the user, smoothing the peaks and reaching the valleys of an uneven surface upon which the sander is utilized.

公开(公告)号：US07085351B2

公开(公告)日：2006-08-01

申请号：US10358160

申请日：2003-02-05

Applicant: Jianping Lu ,  Otto Zhou ,  Yuan Cheng

Inventor： Jianping Lu ,  Otto Zhou ,  Yuan Cheng

IPC: H01J35/32

CPC classification number: H01J35/06 ,  A61B6/032 ,  A61B6/4021 ,  A61B6/4028 ,  A61B6/405 ,  A61B6/4488 ,  A61B6/482 ,  B82Y10/00 ,  H01J3/021 ,  H01J35/065 ,  H01J35/08 ,  H01J35/105 ,  H01J35/14 ,  H01J35/22 ,  H01J35/28 ,  H01J35/30 ,  H01J2201/30469 ,  H01J2235/06 ,  H01J2235/062 ,  H01J2235/064 ,  H01J2235/068 ,  H05G1/34

Abstract: An x-ray generating device includes a field emission cathode formed at least partially from a nanostructure-containing material having an emitted electron current density of at least 4 A/cm2. High energy conversion efficiency and compact design are achieved due to easy focusing of cold cathode emitted electrons and dramatic reduction of heating at the anode. In addition, by pulsing the field between the cathode and the gate or anode and focusing the electron beams at different anode materials, pulsed x-ray radiation with varying energy can be generated from a single device. Methods and apparatus for independent control of electron emission current and x-ray energy in x-ray tubes are also provided. The independent control can be accomplished by adjusting the distance between the cathode and anode. The independent control can also be accomplished by adjusting the temperature of the cathode. The independent control can also be accomplished by optical excitation of the cathode. The cathode can include field emissive materials such as carbon nanotubes.

公开(公告)号：US20050236443A1

公开(公告)日：2005-10-27

申请号：US10830275

申请日：2004-04-22

Applicant: Donald Gringer ,  Yuan Cheng

Inventor： Donald Gringer ,  Yuan Cheng

IPC: B44D3/12 ,  B65D5/72

CPC classification number: B44D3/128 ,  B44D3/127

Abstract: An inventive pouring spout for containers of liquid, having a removable lid and a strip with magnets located thereon. The spout is selectively attachable and is fitted to the diameter of an opening of a particular container. In a preferred embodiment, the spout is fitted to the diameter of a paint can opening, where it may replace the typical lid of a paint can for the duration of its use. Essentially, the spout effectively prevents the entry of paint in the sealing groove of the paint can or on the sides of the can.

Abstract translation: 一种用于液体容器的创新性倾倒嘴，其具有可移除的盖和位于其上的磁体的带。 喷嘴可选择性地附接并且被安装到特定容器的开口的直径上。 在一个优选实施例中，喷嘴适合于油漆罐开口的直径，其中可以在其使用期间替换油漆罐的典型盖。 基本上，喷口有效地防止油漆在油漆罐的密封槽或罐的侧面上的进入。

公开(公告)号：US20050156290A1

公开(公告)日：2005-07-21

申请号：US10959207

申请日：2004-10-07

Applicant: Jeffrey Lien ,  Yuan Cheng

Inventor： Jeffrey Lien ,  Yuan Cheng

IPC: H01L21/58 ,  H01L23/31 ,  H01L23/495

CPC classification number: H01L23/49551 ,  H01L23/3114 ,  H01L23/4951 ,  H01L24/48 ,  H01L24/49 ,  H01L2224/32245 ,  H01L2224/451 ,  H01L2224/48091 ,  H01L2224/4826 ,  H01L2224/49171 ,  H01L2224/73215 ,  H01L2924/00014 ,  H01L2924/00 ,  H01L2924/00015 ,  H01L2224/45099 ,  H01L2224/45015 ,  H01L2924/207

Abstract: A concealable chip leadframe unit structure is disclosed which is made up of multiple lead units arranged in order, each lead in the lead unit is formed by pressing and comprising of a piece body with upper placement plane, the lower surface of the piece body is pressed to form at least an inner conducting plane which can be connected to the chip, and at least one protruding bump is formed adjacent to the inner conducting plane, the end surface of the protruding bump is used as an out-conducting plane to be connected to outside; in this structure, chip can be attached to the upper placement plane of the lead structure, and the inner conducting plane can be connected to the chip through metallic wire.

Abstract translation: 公开了一种可隐藏的芯片引线框单元结构，其由依次布置的多个引线单元构成，引线单元中的每个引线通过压制形成，并且包括具有上放置平面的片体，片体的下表面被按压 至少形成能够连接到芯片的内部导电平面，并且与内部导电平面相邻地形成至少一个突出凸块，突出凸起的端面用作与外部导电平面连接的导电平面 外; 在该结构中，芯片可以安装在引线结构的上部放置平面上，并且内部导电平面可以通过金属线连接到芯片。

公开(公告)号：US09552955B2

公开(公告)日：2017-01-24

申请号：US13291080

申请日：2011-11-07

Applicant: Moritz Beckmann ,  Walter Beyerlein ,  Andreas Böhme ,  Yuan Cheng ,  Jens Fürst ,  Markus Hemmerlein ,  Houman Jafari ,  Jürgen Oelschlegel ,  Qi Qiu ,  Frank Sprenger

Inventor： Moritz Beckmann ,  Walter Beyerlein ,  Andreas Böhme ,  Yuan Cheng ,  Jens Fürst ,  Markus Hemmerlein ,  Houman Jafari ,  Jürgen Oelschlegel ,  Qi Qiu ,  Frank Sprenger

IPC: H05B41/36 ,  H01J35/06 ,  H01J3/02 ,  H05G1/26 ,  H05G1/32 ,  H05G1/48 ,  H05G1/58 ,  H05G1/70

CPC classification number: H01J35/065 ,  H01J3/021 ,  H01J2235/068 ,  H05G1/265 ,  H05G1/32 ,  H05G1/48 ,  H05G1/58 ,  H05G1/70

Abstract: An electron source includes a plurality of electron emission cathodes and at least one control electrode. A gate current regulator is provided for regulation of current flowing through the at least one control electrode.

Abstract translation: 电子源包括多个电子发射阴极和至少一个控制电极。 提供了栅极电流调节器，用于调节流经至少一个控制电极的电流。