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公开(公告)号：US09586061B2
公开(公告)日：2017-03-07
申请号：US14457250
申请日：2014-08-12
Applicant: CONVERGENT R.N.R LTD
Inventor： Zeev Burshtein , Zeev Harel , Aharon Bar-David , Donald M. Korn
CPC classification number: A61N5/1049 , A61B6/06 , A61B6/4021 , A61B6/4035 , A61B6/483 , A61N5/1065 , A61N5/1077 , A61N5/1084 , A61N2005/1054 , A61N2005/1061 , A61N2005/1091 , A61N2005/1095 , G21K1/04 , G21K1/065 , G21K1/067 , G21K2201/064 , H05G1/70
Abstract: An X-ray system comprises: (a) a source providing an X-ray diverging beam having treatment and imaging angular portions; (b) one or more lenses transforming the treatment portion of the X-ray beam into a converging beam directed to a target; (c) a first shutter located between the X-ray source and the target in the imaging portion of the X-ray radiation; the first shutter being selectively openable such that imaging portion of X-ray beam reaches the target; and (d) a detector configured to detect at least a portion of the imaging radiation after the imaging radiation has interacted with the target to provide imaging information of the target.
Abstract translation: X射线系统包括：（a）提供具有处理和成像角部分的X射线发散光束的光源; （b）一个或多个透镜将X射线束的处理部分转换成指向靶的会聚光束; （c）在X射线辐射的成像部分中位于X射线源和靶之间的第一快门; 所述第一挡板选择性地可打开，使得X射线束的成像部分到达所述目标; 以及（d）检测器，被配置为在所述成像辐射已经与所述目标物体相互作用之后检测所述成像辐射的至少一部分，以提供所述目标的成像信息。
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公开(公告)号：US12109439B2
公开(公告)日：2024-10-08
申请号：US17166064
申请日：2021-02-03
Applicant: Convergent R.N.R Ltd.
Inventor： Aharon Bar-David , Michael Kleckner , Shirly Borukhin , Zeev Harel
IPC: A61N5/10
CPC classification number: A61N5/1075 , A61N5/1065 , A61N2005/1076 , A61N2005/1085
Abstract: A method of a radiotherapy or radiosurgery treatment comprises steps of: (a) providing a converging x-ray beam source configured for emitting a converging X-ray beam propagating along an axis thereof; (b) emitting the converging x-ray beam towards a volume of treatment (VOT) having a length along the axis of the converging X-ray beam ranging between 2 mm and 5 cm within a patient's body such that a waist portion is within the VOT; (c) propagating the beam through tissues previously located relative to the VOT (PO); the VOT per se and tissues distally located to the VOT (DO). The converging X-ray beam characterized by a convergent angle ranging between 2 and 30 degrees providing 80% to 100% of a maximum dose is received by the VOT and less than 60% of the maximum dose is received by the PO and the DO.
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公开(公告)号：US20210113855A1
公开(公告)日：2021-04-22
申请号：US17071098
申请日：2020-10-15
Applicant: CONVERGENT R.N.R LTD.
Inventor： Aharon BAR-DAVID , Michael KLECKNER , Shirly BORUKHIN , Zeev BURSHTEIN , Avigail KELLER , Zeev HAREL
IPC: A61N5/10
Abstract: A method of evaluating a maximal dose deposited by a non-uniform X-ray beam within a medium comprising the steps of: (a) irradiating said medium by said non-uniform X-ray beam penetrating into a depth of said medium along an axis of said X-ray beam; (b) incrementally measuring a number of transversal dose distributions at successive depths along said axis; (c) determining a maximum dose within each of said number of transversal dose distributions; and (d) calculating a 1-Dimesional depth dependance of said maximal doses obtained from said number of transversal dose distributions.
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公开(公告)号：US10265510B2
公开(公告)日：2019-04-23
申请号：US15503006
申请日：2015-08-12
Applicant: CONVERGENT R.N.R LTD
Inventor： Zeev Harel , Zeev Burshtein , Aharon Bar-David , Miri Markovich
Abstract: The present invention provides a method for activating a pro-drug in vivo comprising the steps of: (a) administering a pro-drag to a subject; (b) locating a target site which has been at least partially dosed with the pro-drug at a predetermined concentration; and (d) exposing the target site to X-ray radiation. The step of exposing the target site to X-ray radiation is characterized by providing a converging X-ray of a controllable waist, substantially uniform at the target site, sufficient to convert the pro-drug to an active drug, while the X-ray photon dosage at the target site is higher than the X-ray photon dosage at an adjacent non target site.
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公开(公告)号：US20210193345A1
公开(公告)日：2021-06-24
申请号：US17196340
申请日：2021-03-09
Applicant: CONVERGENT R.N.R LTD.
Inventor： Aharon BAR-DAVID , Zeev HAREL , Zeev BURSHTEIN
Abstract: An X-ray lens arrangement for forming a radiation pattern as a focal track is disclosed. The pattern comprises at least one 3-dimensional focal track of radiation. The aforesaid lens arrangement has a main axis passing through intensity weighted centroids of the Xray source and the pattern. The lens arrangement includes at least one reflecting surface of continuously varying Rowland arcs. Each point belonging to the focal track is linked to each elemental point composing an emitting surface of said source by a corresponding Rowland arc.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20190175953A1
公开(公告)日：2019-06-13
申请号：US16258612
申请日：2019-01-27
Applicant: CONVERGENT R.N.R LTD
Inventor： Aharon BAR-DAVID , Miri MARKOVICH , Zeev BURSHTEIN , Zeev HAREL
IPC: A61N5/10
Abstract: A method of a radiotherapy or radiosurgery treatment comprises steps of: (a) providing a converging x-ray beam source configured for emitting a converging X-ray beam propagating along an axis thereof; (b) emitting the converging x-ray beam towards a volume of treatment (VOT) having a length along the axis of the converging X-ray beam ranging between 2 mm and 5 cm within a patient's body such that a waist portion is within the VOT; (c) propagating the beam through tissues previously located relative to the VOT (PO); the VOT per se and tissues distally located to the VOT (DO). The converging X-ray beam characterized by a convergent angle ranging between 2 and 30 degrees providing 80% to 100% of a maximum dose is received by the VOT and less than 60% of the maximum dose is received by the PO and the DO.
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7.发明申请公开(公告)号：US20180133513A1
公开(公告)日：2018-05-17
申请号：US15102713
申请日：2014-12-07
Applicant: CONVERGENT R,N,R LTD
Inventor： Aharon BAR-DAVID , Miri MARKOVICH , Zeev BURSHTEIN , Zeev HAREL
IPC: A61N5/10
CPC classification number: A61N5/1077 , A61N5/1031 , A61N5/1048 , A61N5/1084
Abstract: A standard of care protocol for increasing efficiency of a radiotherapy or radiosurgery treatment and reducing the treatment's side effects by radiating with a converging x-ray beam source emitting a converging x-ray beam (102) towards at least one volume of treatment (VOT) (103) within a patient's body; the beam is passing through at least one organ preceding said VOT (PO) (105) and at least one organ distal to said VOT (DO) (106); the VOT is receiving, on average, at least 80% of maximum dose whilst thr PO and DO are receiving, on average, no more than 40% of the maximum dose.
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公开(公告)号：US20170232245A1
公开(公告)日：2017-08-17
申请号：US15503006
申请日：2015-08-12
Applicant: CONVERGENT R.N.R LTD
Inventor： Zeev HAREL , Zeev BURSHTEIN , Aharon BAR-DAVID , Miri MARKOVICH
CPC classification number: A61M37/00 , A61K9/0009 , A61K41/00 , A61K41/0052 , A61M2037/0007 , A61N5/10 , A61N2005/1091 , A61N2005/1098
Abstract: The present invention provides a method for activating a pro-drug in vivo comprising the steps of: (a) administering a pro-drag to a subject; (b) locating a target site which has been at least partially dosed with the pro-drug at a predetermined concentration; and (d) exposing the target site to X-ray radiation. The step of exposing the target site to X-ray radiation is characterized by providing a converging X-ray of a controllable waist, substantially uniform at the target site, sufficient to convert the pro-drug to an active drug, whilst the X-ray photon dosage at the target site is higher than the X-ray photon dosage at an adjacent non target site.
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公开(公告)号：US20130170625A1
公开(公告)日：2013-07-04
申请号：US13817562
申请日：2011-08-18
Applicant: Zeev Burshtein , Aharon Bar-David , Zeev Harel
Inventor： Zeev Burshtein , Aharon Bar-David , Zeev Harel
IPC: G21K1/06
CPC classification number: G21K1/06 , A61N5/1042 , A61N5/1084 , A61N2005/1091 , A61N2005/1095 , G21K1/046 , G21K5/04 , G21K2201/062 , G21K2201/064 , G21K2201/067
Abstract: An X-ray system is arranged for providing X-ray exposure to a target volume. The aforesaid X-ray system comprises an X-ray source and at least one focusing lens. The provided exposure is distributed over a volume of the target in a substantially uniform manner.
Abstract translation: 布置X射线系统以提供对目标体积的X射线曝光。 上述X射线系统包括X射线源和至少一个聚焦透镜。 所提供的曝光以基本均匀的方式分布在目标体积上。
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公开(公告)号：US20220219011A9
公开(公告)日：2022-07-14
申请号：US17071098
申请日：2020-10-15
Applicant: CONVERGENT R.N.R LTD.
Inventor： Aharon BAR-DAVID , Michael KLECKNER , Shirly BORUKHIN , Zeev BURSHTEIN , Avigail KELLER , Zeev HAREL
IPC: A61N5/10
Abstract: A method of evaluating a maximal dose deposited by a non-uniform X-ray beam within a medium comprising the steps of: (a) irradiating said medium by said non-uniform X-ray beam penetrating into a depth of said medium along an axis of said X-ray beam; (b) incrementally measuring a number of transversal dose distributions at successive depths along said axis; (c) determining a maximum dose within each of said number of transversal dose distributions; and (d) calculating a 1-Dimesional depth dependance of said maximal doses obtained from said number of transversal dose distributions.
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