公开(公告)号：US20240101810A1

公开(公告)日：2024-03-28

申请号：US17768986

申请日：2020-09-04

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Eun Ho SOHN ,  Shin Hong YOOK ,  Hong Suk KANG ,  In Joon PARK ,  Sang Goo LEE ,  Soo Bok LEE ,  Won Wook SO ,  Hyeon Jun HEO ,  Dong Je HAN ,  Seon Woo KIM

IPC: C08L33/16 ,  C09D133/16

CPC classification number: C08L33/16 ,  C09D133/16

Abstract: The present invention relates to a composition for forming a composite polymer film, a method for preparing the composition for forming a composite polymer film, a composite polymer film and a method for preparing the composite polymer film. The composition for forming a composite polymer film comprises: a fluorine-based polymer solution comprising a fluorine-based polymer; and polyvinylidene fluoride nanoparticles dispersed in the fluorine-based polymer solution. The method for preparing the composition for forming a composite polymer film comprises the steps of: preparing a fluorine-based polymer solution comprising a fluorine-based polymer; and dispersing polyvinylidene fluoride nanoparticles in the fluorine-based polymer solution. The composite polymer film comprises: a polymer matrix formed from a fluorine-based polymer; and polyvinylidene fluoride nanoparticles dispersed in the polymer matrix. The method for preparing the composite polymer film comprises the steps of: preparing a fluorine-based polymer solution comprising a fluorine-based polymer; preparing a composition, for forming a composite polymer film, by dispersing polyvinylidene fluoride nanoparticles in the fluorine-based polymer solution; and forming the composite polymer film by applying the composition for forming a composite polymer film.

公开(公告)号：US20220119761A1

公开(公告)日：2022-04-21

申请号：US17646978

申请日：2022-01-04

Applicant: INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Jin Cheol KIM ,  Hun KIM ,  Kee-Sun SHIN ,  Ja Yeong JANG ,  Gyung Ja CHOI ,  Yong Ho CHOI ,  Kyoung Soo JANG ,  Mi Bang KIM

IPC: C12N1/14 ,  A01N63/34

Abstract: The present invention relates to an Aspergillus niger F22 strain having a nematicidal activity against plant-parasitic nematodes; a nematicidal microorganism agent against plant-parasitic nematodes, containing, as an active ingredient, the strain, a spore, a fungal hyphal mass, or a culture liquid thereof; a method for controlling plant-parasitic nematodes, having a step of administering the microorganism agent to a crop, a crop seed, or a field; and a method for preparation of a nematicidal microorganism agent against plant-parasitic nematodes, having a step of culturing the strain.

公开(公告)号：US08754209B2

公开(公告)日：2014-06-17

申请号：US13132772

申请日：2009-12-04

Applicant: Tae Bo Sim ,  Jung Beom Son ,  Hwan Kim ,  Dong Sik Park ,  Hwan Geun Choi ,  Young Jin Ham ,  Jung Mi Hah ,  Kyung Ho Yoo ,  Chang Hyun Oh ,  So Ha Lee ,  Jae Du Ha ,  Sung Yun Cho ,  Byoung Mog Kwon ,  Dong Cho Han

Inventor： Tae Bo Sim ,  Jung Beom Son ,  Hwan Kim ,  Dong Sik Park ,  Hwan Geun Choi ,  Young Jin Ham ,  Jung Mi Hah ,  Kyung Ho Yoo ,  Chang Hyun Oh ,  So Ha Lee ,  Jae Du Ha ,  Sung Yun Cho ,  Byoung Mog Kwon ,  Dong Cho Han

IPC: C07D413/14 ,  C07D413/12 ,  C07D417/12 ,  C07D401/12 ,  C07D405/12 ,  C07D403/12 ,  C07D409/12 ,  C07D231/56

CPC classification number: C07D413/14 ,  C07D231/56 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D407/04 ,  C07D409/04 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

Abstract: Disclosed are novel indazole derivatives represented by the following Chemical Formula 1 or pharmaceutically acceptable salts, hydrates or solvates thereof, and pharmaceutical compositions for the prevention or treatment of proliferative diseases, containing the same as an active ingredient. Having potent inhibitory effect against protein kinase, such as b-raf, KDR, Fms, Tie2, SAPK2a and Ret, inducing diseases caused by abnormal cell proliferation, the novel indazole derivatives can be used for the prevention or treatment of diseases caused by abnormal cell proliferation.

Abstract translation: 公开了由以下化学式1表示的新型吲唑衍生物或其药学上可接受的盐，水合物或溶剂合物，以及用于预防或治疗增殖性疾病的药物组合物，其含有活性成分。 具有对蛋白激酶（如b-raf，KDR，Fms，Tie2，SAPK2a和Ret）的有效抑制作用，诱导由异常细胞增殖引起的疾病，该新型吲唑衍生物可用于预防或治疗由异常细胞引起的疾病 增殖。

公开(公告)号：US07741323B2

公开(公告)日：2010-06-22

申请号：US10599911

申请日：2005-04-13

Applicant: Hyae Gyeong Cheon ,  Sung-Eun Yoo ,  Sung Soo Kim ,  Sung-Don Yang ,  Kwang-Rok Kim ,  Sang Dal Rhee ,  Jin Hee Ahn ,  Seung Kyu Kang ,  Won Hoon Jung ,  Sung Dae Park ,  Nam Gee Kim ,  Jang Hyuk Lee ,  Sun Chul Huh ,  Jae Mok Lee ,  Seog Beom Song ,  Soon Ji Kwon ,  Jong Hoon Kim ,  Jeong-Hyung Lee ,  Seung Jun Kim

Inventor： Hyae Gyeong Cheon ,  Sung-Eun Yoo ,  Sung Soo Kim ,  Sung-Don Yang ,  Kwang-Rok Kim ,  Sang Dal Rhee ,  Jin Hee Ahn ,  Seung Kyu Kang ,  Won Hoon Jung ,  Sung Dae Park ,  Nam Gee Kim ,  Jang Hyuk Lee ,  Sun Chul Huh ,  Jae Mok Lee ,  Seog Beom Song ,  Soon Ji Kwon ,  Jong Hoon Kim ,  Jeong-Hyung Lee ,  Seung Jun Kim

IPC: C07C255/47 ,  C07C251/32 ,  C07C237/24 ,  C07C69/74 ,  C07D413/12 ,  C07D333/28 ,  C07D333/22 ,  C07D333/24 ,  C07D333/60 ,  C07D317/60 ,  C07D317/70 ,  C07D307/54 ,  C07D277/30 ,  C07D265/30 ,  C07D295/135 ,  C07D233/64 ,  C07D213/53 ,  C07D213/64 ,  A61K31/5377 ,  A61K31/495 ,  A61K31/4402 ,  A61K31/44 ,  A61K31/426 ,  A61K31/4164 ,  A61K31/381 ,  A61K31/36 ,  A61K31/277 ,  A61K31/216 ,  A61K31/165

CPC classification number: C07D213/30 ,  C07C291/02 ,  C07C309/66 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2603/74 ,  C07D213/53 ,  C07D233/64 ,  C07D277/24 ,  C07D295/088 ,  C07D295/185 ,  C07D307/54 ,  C07D317/60 ,  C07D317/70 ,  C07D333/24 ,  C07D333/28 ,  C07D417/12

Abstract: An indene derivative for selectively modulating the activities of peroxisome proliferator activated receptors (PPARs) having the following formula (I): wherein, R1 is C1-6 alkyl, C1-6 alkenyl, or C3-6 cycloalkyl, each of which is unsubstituted or substituted with one or more phenyl groups; R2 is H, CN, CO2Ra, CH2CO2Ra, CONRbRc, or phenyl; R3 is C1-6 alkyl, C3-6 cycloalkyl, naphthyl, phenyl, being each unsubstituted or substituted with one or more substituents selected from the group consisting of halogen, CN, NH2, NO2, ORa, phenyloxy, C1-6 alkyl, and C3-6 cycloalkyl; and R4, R5, R6, and R7 are each independently H, OH, OSO2CH3, O(CH2)mRe, CH2Rf, OCOCH2ORg, OCH2CH2ORg, OCH2CH═CHRg, or pyridine-2-yloxy, or R5 and R6 together form OCH2O.

Abstract translation: 用于选择性调节具有下式（I）的过氧化物酶体增殖物激活受体（PPAR）的活性的茚衍生物：其中，R 1为C 1-6烷基，C 1-6链烯基或C 3-6环烷基，其各自为未取代或未取代的 被一个或多个苯基取代; R2是H，CN，CO2Ra，CH2CO2Ra，CONRbRc或苯基; R 3是C 1-6烷基，C 3-6环烷基，萘基，苯基，各自未被取代或被一个或多个选自卤素，CN，NH 2，NO 2，OR a，苯氧基，C 1-6烷基和 C3-6环烷基; 和R 4，R 5，R 6和R 7各自独立地为H，OH，OSO 2 CH 3，O（CH 2）m RE，CH 2 R f，OCOCH 2 OR g，OCH 2 CH 2 OR g，OCH 2 CH = CHR g或吡啶-2-基氧基，或者R 5和R 6一起形成OCH 2 O。

公开(公告)号：US10765669B2

公开(公告)日：2020-09-08

申请号：US16470014

申请日：2017-12-15

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Sungchan Cho ,  Miri Choi ,  Joo Youn Lee

IPC: A61K31/381 ,  A61K31/444 ,  A23L33/10

Abstract: The present invention relates to a pharmaceutical composition the prevention or treatment of DYRK-related diseases containing a pyridine-based compound as an active ingredient, a pyridine-based compound of the present invention which is used as an active ingredient of the pharmaceutical composition inhibits the activity of DYRK1A with very high efficacy and selectivity, thereby can be used effectively in the prevention or treatment of DYRK-related diseases, such as Down syndrome, degenerative brain diseases, cancer, and metabolic diseases.

公开(公告)号：US20240219333A1

公开(公告)日：2024-07-04

申请号：US18003757

申请日：2021-06-15

Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

Inventor： Jung-Hwa Oh ,  Jaehwan Ahn ,  Seokjoo Yoon ,  Hyoung-Yun Han ,  Mi Young Son ,  Kwang Bo Jung ,  Cho Rok Jung ,  Janghwan Kim

IPC: G01N27/04 ,  C12M1/26 ,  C12M1/34 ,  G01N33/483

CPC classification number: G01N27/041 ,  C12M33/04 ,  C12M33/12 ,  C12M41/40 ,  G01N33/4833

Abstract: The present invention provides an impedance-based organoid evaluation system comprising an organoid deformation generating unit including a first tube and a plurality of second tubes having a diameter smaller than that of the first tube, connected to one end of the first tube or inserted therein; and an impedance measuring unit connected to the organoid deformation generating unit and including an impedance analyzer for measuring the impedance of the organoid, and evaluating the organoid from the impedance measured by the impedance measuring unit.

公开(公告)号：US20200085803A1

公开(公告)日：2020-03-19

申请号：US16470014

申请日：2017-12-15

Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Sungchan CHO ,  Miri CHOI ,  Joo Youn LEE

IPC: A61K31/444 ,  A23L33/10

Abstract: The present invention relates to a pharmaceutical composition the prevention or treatment of DYRK-related diseases containing a pyridine-based compound as an active ingredient, a pyridine-based compound of the present invention which is used as an active ingredient of the pharmaceutical composition inhibits the activity of DYRK1A with very high efficacy and selectivity, thereby can be used effectively in the prevention or treatment of DYRK-related diseases, such as Down syndrome, degenerative brain diseases, cancer, and metabolic diseases.

公开(公告)号：US08865762B2

公开(公告)日：2014-10-21

申请号：US13384560

申请日：2010-07-16

Applicant: Byoung Mog Kwon ,  Dong Cho Han ,  Myung Ae Bae ,  Seong Hwan Kim ,  Yong Ki Min

Inventor： Byoung Mog Kwon ,  Dong Cho Han ,  Myung Ae Bae ,  Seong Hwan Kim ,  Yong Ki Min

IPC: A61K31/35 ,  A61K31/352 ,  A23L1/30

CPC classification number: A61K31/352 ,  A23L33/10 ,  A61K31/35

Abstract: The present invention relates to a pharmaceutical composition for the prevention or treatment of bone diseases comprising colforsin daropate, and more particularly, the present invention relates to a pharmaceutical composition for the prevention or treatment of bone diseases such as bone fracture and osteoporosis, which inhibits osteoclast differentiation and bone resorption caused by osteoclasts and promotes osteoblast differentiation and the activity of osteoblasts, and a health functional food composition comprising colforsin daropate.

Abstract translation: 本发明涉及一种用于预防或治疗骨疾病的药物组合物，所述骨疾病包括焦虑素，尤其本发明涉及一种用于预防或治疗诸如骨折和骨质疏松症等骨疾病的药物组合物，其抑制破骨细胞 破骨细胞引起的分化和骨吸收并促进成骨细胞分化和成骨细胞的活性，以及​​包含大肠杆菌的健康功能食品组合物。

公开(公告)号：US20090042872A1

公开(公告)日：2009-02-12

申请号：US12087474

申请日：2006-12-08

Applicant: Seong Eon Ryu ,  Seung Jun Kim ,  Dae Gwin Jeong ,  Sang Hyeup Lee ,  Suk Kyeong Jung ,  Hwan Mook Kim ,  Song Kyu Park ,  Ki Ho Lee ,  Chang Woo Lee ,  Joong-Kwon Choi ,  Jin Hee Ahn

Inventor： Seong Eon Ryu ,  Seung Jun Kim ,  Dae Gwin Jeong ,  Sang Hyeup Lee ,  Suk Kyeong Jung ,  Hwan Mook Kim ,  Song Kyu Park ,  Ki Ho Lee ,  Chang Woo Lee ,  Joong-Kwon Choi ,  Jin Hee Ahn

IPC: A61K31/426 ,  C07D277/04 ,  C07D413/12 ,  A61K31/538 ,  A61P3/10 ,  A61P35/00 ,  A61P3/04 ,  A61K31/5377 ,  C07D265/34

CPC classification number: C07D277/20 ,  C07D417/12

Abstract: Disclosed herein are rhodanine derivatives, a method for the preparation thereof, and a pharmaceutical composition containing the same. The rhodanine derivatives have inhibitory activity against protein phosphatases (PPase) such as PTP1B, Prl-3, LAR, CD45, Cdc25A, Cdc25B, Cdc25C, Yop, PP1 and VHR, and can be applied for the prevention and treatment of PPase-caused diseases, including autoimmune diseases, diabetes, impaired glucose intolerance, insulin resistance, obesity, cancers, etc. when the inhibitory activity thereof is modulated.

Abstract translation: 本文公开了绕丹宁衍生物，其制备方法和含有它们的药物组合物。 罗丹明衍生物对PTP1B，Prl-3，LAR，CD45，Cdc25A，Cdc25B，Cdc25C，Yop，PP1和VHR等蛋白磷酸酶（PPase）具有抑制活性，可用于预防和治疗PPase引起的疾病 包括自身免疫性疾病，糖尿病，葡萄糖耐受不良，胰岛素抵抗，肥胖，癌症等。

公开(公告)号：US20240414929A1

公开(公告)日：2024-12-12

申请号：US18397073

申请日：2023-12-27

Applicant: KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Won Suk SHIN ,  Hang Ken LEE ,  Chang Eun SONG ,  Kyung Geun LIM ,  Su Hyeon LEE

IPC: H10K30/82 ,  H10K30/40

Abstract: The present invention relates to a semiconductor device and a semiconductor material, and more specifically, to an organic semiconductor thin film transistor having a vertical structure, a fusion device of an optical semiconductor material, and a method of manufacturing the same, provides a vertical organic transistor including a substrate, a first electrode layer formed on the substrate, a lower charge transport layer formed on the first electrode layer, a photosensitive layer formed on the lower charge transport layer, an upper charge transport layer formed on the photosensitive layer, a second electrode layer including a base electrode formed on the upper charge transport layer, a plurality of pinholes formed in the base electrode and configured to provide a movement path of charges, and a metal oxide layer surrounding a surface of the base electrode and the pinholes, an organic active layer formed on the second electrode layer, and a third electrode layer formed on the organic active layer.