公开(公告)号：US20250161948A1

公开(公告)日：2025-05-22

申请号：US18816535

申请日：2024-08-27

Applicant: Biomeme, Inc.

Inventor： Marc Dominic DeJohn ,  Tom Welsh ,  Luke Gary

IPC: B01L7/00 ,  B01L1/00 ,  B01L3/00 ,  G01N21/64

Abstract: The present disclosure provides devices, systems, methods for processing and/or analyzing a biological sample. An analytic device for processing and/or analyzing a biological sample may comprise a moving carriage. The analytic device may be portable. The analytic device may receive instructions for performing an assay from a mobile electronic device external to a housing of the analytic device.

公开(公告)号：US12239982B2

公开(公告)日：2025-03-04

申请号：US17292782

申请日：2019-11-13

Applicant: Sindy K. Y. Tang ,  Kari C. Nadeau ,  Bryan J. Bunning ,  Nicolas Castano ,  Fengjiao Lyu ,  Seth Cordts ,  The Board of Trustees of the Leland Stanford Junior University

Inventor： Sindy K. Y. Tang ,  Kari C. Nadeau ,  Bryan J. Bunning ,  Nicolas Castano ,  Fengjiao Lyu ,  Seth Cordts

IPC: B01L1/00 ,  B01L3/00 ,  G01N33/50 ,  G01N33/543 ,  G01N33/569

Abstract: Devices, methods, and kits are provided for allergy testing based on basophil activation in a blood sample. Susceptibility of an individual to an allergic reaction to an allergen is detected by collecting a blood sample from the individual and assaying for activation of basophils in response to stimulation with an allergen. In particular, a microfluidic device is provided for automating the assay for detecting basophil activation as an indication of the susceptibility of an individual to an allergic reaction as well as kits containing such a device and diagnostic methods for using such a device for allergy testing. Additionally, such a microfluidic device can be adapted for multiplexed detection of allergic responses to multiple allergens by performing assays in parallel to detect the basophil responses to each allergen.

公开(公告)号：US12208397B2

公开(公告)日：2025-01-28

申请号：US17265441

申请日：2019-08-02

Applicant: RANDOX LABORATORIES LTD

Inventor： Paul Courtney ,  Martin Reid ,  Stuart Jackson ,  John Lamont ,  Ivan McConnell ,  Peter Fitzgerald

IPC: B01L9/00 ,  B01L1/00 ,  B25J9/02

Abstract: There is provided a pipette tip disposal assembly. The assembly comprises a receiving element adapted to support an end of at least one pipette tip, the at least one pipette tip being toppled in use from the receiving element along a first direction; and a container positioned to receive the at least one toppled pipette tip, the at least one pipette tip falling towards a base of the container on being received by the container. The base of the container has a first linear dimension aligned with the first direction corresponding to the length of a pipette tip.

公开(公告)号：US12208382B2

公开(公告)日：2025-01-28

申请号：US17699872

申请日：2022-03-21

Applicant: Roche Diagnostics Hematology, Inc. ,  Roche Diagnostics Operations, Inc.

Inventor： Ertan Ergezen ,  Stephen Conroy ,  Rijk Oosterbroek ,  Claudio Cherubini

IPC: B01L1/00 ,  B01L3/02 ,  B01L9/00 ,  G01N1/31 ,  G01N35/00

Abstract: The disclosure features methods, fluid delivery platforms, and apparatus for preparing a sample on a substrate that includes a substrate handler configured to move a substrate between a first position and a second position, and a platform positioned so that when the substrate is in the second position, the platform faces the substrate, where the platform includes a fluid delivery area having a second surface formed from a hydrophilic material for which a water contact angle is 40 degrees or less, and a first surface facing the substrate when the substrate is in the second position, formed from a hydrophobic material for which a water contact angle is 100 degrees or more.

公开(公告)号：US12162014B2

公开(公告)日：2024-12-10

申请号：US17703465

申请日：2022-03-24

Applicant: Amazon Technologies, Inc.

Inventor： Jasmin B. Farshi ,  Pan Zhang ,  Jonathan Barry Hirst ,  Babak Ziaie ,  Bela Incze

IPC: B01L3/00 ,  B01L1/00 ,  B01L7/00 ,  G01N33/487 ,  G16H10/40 ,  G16H40/40 ,  C12Q1/686

Abstract: Systems, methods, and collection devices are disclosed for rapid, local PCR testing. The system may include a PCR testing module, memory configured to store computer-executable instructions, and at least one computer processor configured to access the memory and execute the computer executable instructions to: (i) receive an order for a PCR diagnostic test; (ii) associate a sample collection device (SCD) received by the PCR testing module with the order for a PCR diagnostic test; (iii) instruct the PCR testing module to conduct the PCR diagnostic test on a biological specimen in the SCD received by the PCR testing module; and (iv) cause presentation of results of the PCR diagnostic test.

公开(公告)号：US12090483B2

公开(公告)日：2024-09-17

申请号：US17703570

申请日：2022-03-24

Applicant: Amazon Technologies, Inc.

Inventor： Jasmin B. Farshi ,  Pan Zhang ,  Jonathan Barry Hirst ,  Babak Ziaie ,  Bela Incze ,  Babar M. Koraishy

IPC: C12Q1/686 ,  B01L1/00 ,  B01L3/00 ,  B01L7/00 ,  G01N33/487 ,  G16H10/40 ,  G16H40/40

CPC classification number: B01L3/5029 ,  B01L1/50 ,  B01L3/5025 ,  B01L7/5255 ,  G01N33/48771 ,  G01N33/48792 ,  G16H10/40 ,  G16H40/40 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/082 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/027 ,  B01L2300/044 ,  B01L2300/0609 ,  B01L2300/0654 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2300/1805 ,  B01L2300/1894 ,  B01L2400/0478 ,  C12Q1/686

Abstract: Systems, methods, and collection devices are disclosed for rapid, local PCR testing. The PCR testing system may be configured for use with a disposable sample collection device that includes a swab configured for collecting a biological sample from a patient; and a sample container configured to receive the swab and separate a bulk quantity of the biological sample from the swab for containment in a bulk collection chamber, which is located with the sample container, wherein the sample container is configured to meter a selected volume of the biological sample into a PCR sample tube, which contains a lyophilized master mix, releasably attachable to the sample container.

公开(公告)号：US20240228943A1

公开(公告)日：2024-07-11

申请号：US18441850

申请日：2024-02-14

Applicant: EMD Millipore Corporation

Inventor： David Dixon Newbold ,  Clinton Boyd Pepper ,  David Andrew Hansen

IPC: C12M1/00 ,  B01D27/08 ,  B01D35/26 ,  B01D61/18 ,  B01D63/00 ,  B01D63/02 ,  B01L1/00 ,  B01L3/00 ,  C12M1/12 ,  C12M1/26 ,  C12M3/00 ,  H04W74/0808 ,  H04W84/12

CPC classification number: C12M47/02 ,  B01D61/18 ,  B01D63/02 ,  B01L3/502 ,  C12M23/28 ,  C12M23/42 ,  C12M29/04 ,  C12M29/16 ,  C12M33/04 ,  C12M33/14 ,  H04W74/0808 ,  B01D27/08 ,  B01D35/26 ,  B01D63/005 ,  B01D63/028 ,  B01D2313/203 ,  B01D2313/24 ,  B01D2315/10 ,  B01L1/52 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2400/0403 ,  B01L2400/0475 ,  B01L2400/0478 ,  C12M1/126 ,  C12M37/02 ,  H04W84/12

Abstract: A filtration system, having a filtration unit comprising a housing with a sample inlet, a sample outlet, one or more valves, a first actuator, and a second actuator and a third actuator; and a cassette adapted to fit the filtration unit, the cassette having a filter; a first reservoir in fluid communication with the filter, the first reservoir being arranged to couple to the first actuator for imparting flow to a cell-containing solution in a first direction through the filter; a second reservoir in fluid communication with the filter, the second reservoir being arranged to couple to the second actuator for imparting flow to a cell-containing solution in a second direction through said filter, wherein the second direction opposes the first direction; and a third reservoir.

公开(公告)号：US11986823B2

公开(公告)日：2024-05-21

申请号：US17053012

申请日：2019-05-02

Applicant: Robert Bosch GmbH

Inventor： Franz Laermer

IPC: B01L1/00 ,  B01L3/00 ,  C12Q1/6806 ,  C12Q1/6869

CPC classification number: B01L3/502761 ,  C12Q1/6806 ,  C12Q1/6869 ,  B01L2200/0663 ,  B01L2300/0636 ,  B01L2300/0896 ,  C12Q2531/113 ,  G01N2223/07

Abstract: A microfluidic device includes an array unit and a nanostructure connected to the array unit, wherein the array unit comprises array cells with substances for a polymerase chain reaction. The array cells include nucleotides with stop properties according to the Sanger sequencing method and primers for an asymmetric polymerase chain reaction. The nanostructure is configured to determine lengths of nucleotide strands formed by the polymerase chain reaction.

公开(公告)号：US11739411B2

公开(公告)日：2023-08-29

申请号：US16673196

申请日：2019-11-04

Applicant: Applied Materials, Inc.

Inventor： Lit Ping Lam ,  Sriskantharajah Thirunavukarasu ,  Ian Ong

IPC: C23C14/00 ,  H01J37/32 ,  H01J37/34 ,  C23C16/44 ,  B81C1/00 ,  B33Y80/00 ,  B22F10/00 ,  B29L31/18 ,  F27D1/00 ,  B29L31/34 ,  F27B15/06 ,  B29L31/00 ,  E04B2/00 ,  F16M1/08 ,  B01L1/00

CPC classification number: C23C14/0068 ,  B22F10/00 ,  B33Y80/00 ,  B81C1/00373 ,  C23C16/4404 ,  H01J37/32477 ,  H01J37/3488 ,  B01L1/00 ,  B29L2031/18 ,  B29L2031/3481 ,  B29L2031/7156 ,  E04B2/00 ,  F16M1/08 ,  F27B15/06 ,  F27D1/0006 ,  H01J37/3211 ,  H01J37/32495 ,  H01J37/32807 ,  Y10T428/139

Abstract: Disclosed are embodiments for an engineered feature formed as a part of or on a chamber component. In one embodiment, a chamber component for a processing chamber includes a component part body having unitary monolithic construction. The component part body has an outer surface. An engineered complex surface is formed on the outer surface. The engineered complex surface has a first lattice framework formed from a plurality of first interconnected laths and a plurality of first openings are bounded by three or more laths of the plurality of laths.

公开(公告)号：US11695263B2

公开(公告)日：2023-07-04

申请号：US18054706

申请日：2022-11-11

Applicant: JUSTRITE MANUFACTURING COMPANY, LLC

Inventor： Ronald Frank Auer

IPC: H02G3/22 ,  B01L1/00 ,  H02G3/04 ,  H05K5/06

CPC classification number: H02G3/22 ,  B01L1/50 ,  H02G3/0412 ,  H05K5/069

Abstract: Methods for installing electronic connections into a Factory Mutual certified cabinet may comprise providing a double walled cabinet. The double walled cabinet ay comprise an outer cabinet wall, and inner cabinet wall, and an airgap between the inner cabinet wall and the outer cabinet wall. The method may comprise the steps of including a first large hole in a surface of the outer cabinet wall and including a first small hole in a surface of the inner cabinet wall. Methods can additionally include the steps of inserting a first bulkhead fitting into the first small hole in the surface of the inner cabinet wall via the first large hole and covering the first large hole in the surface of the outer cabinet wall. Methods may additionally include the first small hole at least partially overlapping the first large hole when viewed from a plane normal to the first large hole.